The Registry of Toxic Effects of Chemical Substances

Adipic acid, bis (2 - ethylhexyl) ester

RTECS #: AU9700000

CAS #: 103-23-1

UPDATE: November 2004 MW: 370.64 MF: C22H42O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. ADO (lubricating oil)
  2. Adipol 2EH
  3. BEHA
  4. Bis (2 - ethylhexyl) adipate
  5. Bis - (2 - ethylhexyl) ester kyseliny adipove (Czech)
  6. Bisoflex DOA
  7. Crodamol DOA
  8. DOA
  9. Di (2 - ethylhexyl) adipate
  10. Di (2 - ethylhexyl) adipate
  11. Di - 2 - ethylhexyl adipate
  12. Dioctyl adipate
  13. Effomoll DOA
  14. Ergoplast ADDO
  15. Flexol A 26
  16. Hatcol 2908
  17. Hexanedioic acid, bis (2 - ethylhexyl) ester (9CI)
  18. Hexanedioic acid, dioctyl ester
  19. Kemester 5652
  1. Kodaflex DOA
  2. Lankroflex DOA
  3. Mollan S
  4. Monoplex DOA
  5. Morflex 310
  6. NCI - C54386
  7. Octyl adipate
  8. PX - 238
  9. Plastomoll DOA
  10. Reomol DOA
  11. Rucoflex Plasticizer DOA
  12. Sansocizer DOA
  13. Sicol 250
  14. Staflex DOA
  15. Truflex DOA
  16. Uniflex DOA
  17. Vestinol OA
  18. Wickenol 158
  19. Witamol 320


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 400 mg/L EMMUEG 10(Suppl 10),1,1987
dominant lethal test intraperitoneal
mouse 		1,000 mg/kg TXAPA9 32,566,1975
unscheduled DNA synthesis oral
rat 		378 µmol/kg CRNGDP 8,1433,1987
other mutation test systems oral
mouse 		2 gm/kg MUREAV 343,157,1995
phage inhibition capacity Escherichia coli 25 µg/well MUREAV 260,349,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 15 gm/kg (5-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JPMSAE 62,1596,1973
intraperitoneal
rat 		lowest published toxic dose: 30 gm/kg (5-15 day pregnant) Reproductive: Other developmental abnormalities JPMSAE 62,1596,1973
oral
rat 		lowest published toxic dose: 18 gm/kg (7-21 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) REPTED 17,163,2003
oral
rat 		lowest published toxic dose: 14.4 gm/kg (7-21 day pregnant/3 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) REPTED 17,163,2003
oral
rat 		lowest published toxic dose: 13.6 gm/kg (7-23 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		REPTED 17,163,2003
oral
rat 		lowest published toxic dose: 30.4 gm/kg (7-23 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system 		REPTED 17,163,2003
oral
rat 		lowest published toxic dose: 11.2 gm/kg (7-21 day pregnant/13 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) REPTED 17,163,2003


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 1,038 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTPTR* NTP-TR-212,1981
oral
mouse 		toxic dose : 2,163 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTPTR* NTP-TR-212,1981
oral
mouse 		toxic dose : 1,048 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		EVHPAZ 65,271,1986
oral
mouse 		lowest published toxic dose: 2,163,000 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** PB82-185927
oral
mouse 		lowest published toxic dose: 1,038,240 mg/kg/103 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		NTIS** PB82-185927


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 5,000 mg/kg N/R BFUUA* -,153,1997
intraperitoneal
rat 		lethal dose (50 percent kill): >50 mL/kg N/R JPMSAE 62,1596,1973
intraperitoneal
rat 		lethal dose (50 percent kill): 46,000 mg/kg N/R BFUUA* -,153,1997
intraperitoneal
rabbit 		lethal dose (50 percent kill): 38,000 mg/kg Eye: Lacrimation

Eye: Conjunctiva irritation 		BFUUA* -,153,1997
intravenous
rat 		lethal dose (50 percent kill): 900 mg/kg N/R BFUUA* -,153,1997
intravenous
rabbit 		lethal dose (50 percent kill): 540 mg/kg N/R BFUUA* -,153,1997
oral
guinea pig 		lethal dose (50 percent kill): 12,900 mg/kg N/R BFUUA* -,153,1997
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 15 gm/kg N/R IPSTB3 3,93,1976
oral
mouse 		lethal dose (50 percent kill): 15,000 mg/kg N/R BFUUA* -,153,1997
oral
rat 		lethal dose (50 percent kill): 7,392 mg/kg N/R BFUUA* -,153,1997
skin
rabbit 		lethal dose (50 percent kill): 16 mL/kg N/R AMIHBC 4,119,1951
skin
rabbit 		lethal dose (50 percent kill): 8,410 mg/kg/24 hour N/R BFUUA* -,153,1997


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 168 gm/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-212,1981
oral
mouse 		lowest published toxic dose: 280 gm/kg/13 week- continuous Liver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TXCYAC 123,217,1997
oral
mouse 		lowest published toxic dose: 500 mg/kg/5 day- continuous Liver: Changes in liver weight

Liver: Liver function tests impaired

Biochemical: Metabolism (intermediary): Lipids including transport 		BFUUA* -,153,1997
oral
rat 		lowest published toxic dose: 25,200 mg/kg/3 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOLED5 10,379,1982
oral
rat 		lowest published toxic dose: 191 gm/kg/13 week- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TXCYAC 123,217,1997
oral
rat 		lowest published toxic dose: 500 mg/kg/5 day- continuous Liver: Changes in liver weight

Liver: Liver function tests impaired

Biochemical: Metabolism (intermediary): Lipids including transport 		BFUUA* -,153,1997
oral
rat 		lowest published toxic dose: 8.45 gm/kg/14 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		ARTODN Suppl.12,274,1988
oral
rat 		lowest published toxic dose: 18,000 mg/kg/15 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 17,163,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 77,564,2000
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 77,564,2000
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80276;
Number of Industries 19;
Total Number of Facilities 534;
Number of Occupations 31;
Total Number of Employees Exposed 11,847
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80276;
Number of Industries 15;
Total Number of Facilities 524;
Number of Occupations 21;
Total Number of Employees Exposed 15,636;
Total Number of Female Employees Exposed 3,628


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive/dose response: Rodent dominant lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a plasticizer, a solvent and emulsifier
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8917
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:mouse
NCI Carcinogenesis Studies (feed);no evidence:rat


REFERENCES:

CODEN
REFERENCE
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BFUUA* Beratergremium fuer umweltrelevante Altstoffe (BUA. Gesellschaft Deutscher Chemiker. Weinheim ; New York : VCH) 1992-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a plasticizer, a solvent and emulsifier

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 39393-67-4
ALT CAS #: 63637-48-9
ALT CAS #: 70147-21-6
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