The Registry of Toxic Effects of Chemical Substances

Adipic acid

RTECS #: AU8400000

CAS #: 124-04-9

UPDATE: November 2004 MW: 146.16 MF: C6H10O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Adilactetten
  2. Acifloctin
  3. Acinetten
  4. Adipic acid (ACGIH)
  5. 1,4 - Butanedicarboxylic acid
  1. Hexanedioic acid
  2. 1,6 - Hexanedioic acid
  3. Kyselina adipova (Czech)
  4. Molten adipic acid
  5. Adipinic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,315,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 275 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes

Blood: Hemorrhage 		JAFCAU 5,759,1957
intravenous
mouse 		lethal dose (50 percent kill): 680 mg/kg Behavioral: Convulsions or effect on seizure threshold

Blood: Hemorrhage 		JAFCAU 5,759,1957
oral
mouse 		lethal dose (50 percent kill): 1,900 mg/kg Gastrointestinal: Other changes JAFCAU 5,759,1957
oral
rat 		lethal dose (50 percent kill): >11 gm/kg N/R GISAAA 48(9),72,1983
oral
rabbit 		lethal dose (50 percent kill): >11 gm/kg N/R GISAAA 48(9),72,1983


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 140 gm/kg/5 week- intermittent Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAONAU 40,1,1967


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 539,77,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 4 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84427;
Number of Industries 21;
Total Number of Facilities 1,068;
Number of Occupations 42;
Total Number of Employees Exposed 14,846
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84427;
Number of Industries 54;
Total Number of Facilities 6,259;
Number of Occupations 66;
Total Number of Employees Exposed 140,635;
Total Number of Female Employees Exposed 77,996


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-SA7/SHE; TRP reversion
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to make NYLON 66, esters for plasticizers and as food additive
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-

Used to make NYLON 66, esters for plasticizers and as food additive

Top 50 chemical production: 1.75 billions lbs in 1992, 1.70 billions in 1991

NIOSH PROFILE (ACIDS, ORGANIC), SRI, 2/77

NIOSH PROFILE (ADIPIC ACID), SRC, 3/81

NIOSH PROFILE (ACIDS, ORGANIC), SRC, 4/78

RTECS Compound Description:
   Mutagen
   Primary Irritant

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