The Registry of Toxic Effects of Chemical Substances

Acrylic acid, ethyl ester

RTECS #: AT0700000

CAS #: 140-88-5

UPDATE: May 2005 MW: 100.13 MF: C5H8O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. 2 - Propanoic acid, ethyl ester
  2. 2 - Propenoic acid, ethyl ester
  3. Acrylate d'ethyle (French)
  4. Acrylsaeureaethylester (German)
  5. Aethylacrylat (German)
  6. Akrylanem etylu (Polish)
  7. Carboset 511
  8. Ethoxycarbonylethylene
  9. Ethyl 2 - propenoate
  10. Ethyl acrylate
  1. Ethyl acrylate (ACGIH:OSHA)
  2. Ethyl propenoate
  3. Ethylacrylaat (Dutch)
  4. Ethylakrylat (Czech)
  5. Ethylester kyseliny akrylove (Czech)
  6. Etil acrilato (Italian)
  7. Etilacrilatului (Romanian)
  8. NCI - C50384
  9. RCRA waste number U113


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
guinea pig 		1,204 ppm/7 hour N/R JIHTAB 31,317,1949
eye
monkey 		1,204 ppm/15 hour- intermittent N/R JIHTAB 31,317,1949
eye
rat 		1,204 ppm/14 hour- intermittent N/R JIHTAB 31,317,1949
eye
rabbit 		45 mg mild UCDS** 12/14/1971
eye
rabbit 		1,204 ppm/7 hour mild JIHTAB 31,317,1949
skin
rabbit 		500 mg open irritation test mild UCDS** 12/14/1971
skin
rabbit 		10 mg/24 hour mild JIHTAB 31,311,1949


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 299 mg/L SCIEAS 236,933,1987
cytogenetic analysis hamster lung 9,800 µg/L GMCRDC 27,95,1981
cytogenetic analysis mouse lymphocyte 20 mg/L ENMUDM 8(Suppl 6),4,1986
cytogenetic analysis oral
mouse 		0.5 ppb EMMUEG 39,69,2002
cytogenetic analysis oral
rat 		0.5 ppb EMMUEG 39,69,2002
mutation in microorganisms mouse lymphocyte 20 mg/L (+enzymatic activation step) ENMUDM 8(Suppl 6),4,1986
mutation in microorganisms Salmonella typhimurium 100 µg/plate (-enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
micronucleus test intraperitoneal
mouse 		225 mg/kg MUREAV 135,189,1984
mutation in mammalian somatic cells mouse lymphocyte 20 mg/L ENMUDM 8(Suppl 6),4,1986
sister chromatid exchange hamster ovary 150 mg/L SCIEAS 236,933,1987
specific locus test oral
mouse 		0.5 ppb EMMUEG 39,69,2002
specific locus test oral
rat 		0.5 ppb EMMUEG 39,69,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 200 ppm/6 hour (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOSCF2 48,240,1999
inhalation
rat 		lowest published toxic concentration: 200 ppm (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female 		TOSCF2 48,240,1999
oral
rat 		lowest published toxic dose: 8 gm/kg (0-19 day pregnant) Reproductive: Other effects on female NTIS** OTS0557583


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 103 gm/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTPTR* NTP-TR-259,1986
oral
mouse 		lowest published toxic dose: 51,500 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB87-204061/AS
oral
rat 		lowest published toxic dose: 51,500 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTPTR* NTP-TR-259,1986
oral
rat 		lowest published toxic dose: 51,500 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB87-204061/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published lethal concentration: 1,204 ppm/7 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cough 		JIHTAB 31,317,1949
inhalation
human 		lowest published toxic concentration: 50 ppm Olfaction: Other olfaction effects

Eye: Other eye effects

Lung, Thorax, or Respiration: Other changes 		34ZIAG -,75,1969
inhalation
monkey 		lethal concentration : >75 ppm/6 hour Olfaction: Deviated nasal septum

Olfaction: Ulcerated nasal septum 		TOXID9 36(1,pt2),113,1997
inhalation
mouse 		lethal concentration (50 percent kill): 16,200 mg/m3 N/R GTPZAB 23(9),55,1979
inhalation
mouse 		lowest published toxic concentration: 200 ppm/6 minute Lung, Thorax, or Respiration: Respiratory depression TOLED5 9,137,1981
inhalation
rat 		lethal concentration (50 percent kill): 1,414 ppm/4 hour Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		NTIS** OTS0520180
inhalation
rat 		lowest published toxic concentration: 4.2 gm/m3/6 hour Liver: Other changes

Endocrine: Hyperglycemia

Biochemical: Metabolism (intermediary): Other 		TXCYAC 65,209,1990
inhalation
rat 		lowest published toxic concentration: 25 ppm/3 hour Olfaction: Change in olfactory nerve

Biochemical: Metabolism (intermediary): Other proteins 		TXAPA9 183,23,2002
inhalation
rabbit 		lowest published lethal concentration: 1,204 ppm/7 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea 		JIHTAB 31,317,1949
intraperitoneal
mouse 		lethal dose (50 percent kill): 599 mg/kg N/R JDREAF 51,526,1972
intraperitoneal
rat 		lethal dose (50 percent kill): 450 mg/kg N/R AMPMAR 36,58,1975
oral
cat 		lethal dose : >800 µL/kg Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting 		NTIS** OTS0521003
oral
mouse 		lethal dose (50 percent kill): 1,799 mg/kg N/R TOLED5 11,125,1982
oral
rat 		lethal dose (50 percent kill): 800 mg/kg N/R BCTKAG 12,405,1979
oral
rabbit 		lethal dose (50 percent kill): 370 mg/kg Gastrointestinal: Alteration in gastric secretion NTIS** OTS0521003
skin
mouse 		lethal dose (50 percent kill): 2,997 mg/kg N/R NTIS** OTS0520999
skin
rat 		lowest published lethal dose: 1,800 mg/kg N/R PJPPAA 32,223,1980
skin
rabbit 		lethal dose (50 percent kill): 500 µL/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Other changes

Skin: After systemic exposure: Dermatitis, other 		NTIS** OTS0520180


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 75 ppm/6 hour/26 week- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		APTOD9 19,A53,1980
inhalation
mouse 		lowest published toxic concentration: 75 ppm/6 hour/2 year- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		DCTODJ 8,1,1985
inhalation
mouse 		lowest published toxic concentration: 75 ppm/6 hour/1 year- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0544830
inhalation
mouse 		lowest published toxic concentration: 300 ppm/6 hour/30 day- intermittent Olfaction: Deviated nasal septum

Olfaction: Ulcerated nasal septum

Olfaction: Other olfaction effects 		NTIS** OTS0540690
inhalation
rat 		lowest published toxic concentration: 75 ppm/6 hour/2 year- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		DCTODJ 8,1,1985
inhalation
rat 		lowest published toxic concentration: 300 ppm/7 hour/30 day- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JIHTAB 31(6),311,1949
inhalation
rat 		lowest published toxic concentration: 75 ppm/6 hour/26 week- intermittent Olfaction: Other olfaction effects NTIS** OTS0520180
oral
mouse 		lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Gastrointestinal: Other changes NTPTR* NTP-TR-259,1986
oral
rat 		lowest published toxic dose: 6,500 mg/kg/13 week- intermittent Gastrointestinal: Other changes NTIS** OTS0540988
oral
rat 		lowest published toxic dose: 183 gm/kg/2 year- continuous Behavioral: Food intake (animal)

Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 6,29,1964
oral
rat 		lowest published toxic dose: 11,200 mg/kg/14 day- intermittent Gastrointestinal: Ulceration or bleeding from stomach NTPTR* NTP-TR-259,1986
oral
rat 		lowest published toxic dose: 800 mg/kg/4 day- intermittent Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Other changes 		TXAPA9 80,323,1985
oral
rat 		lowest published toxic dose: 5,600 mg/kg/28 day- continuous Gastrointestinal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0533909


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 ppm;short term exposure limit 15 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 15 ppm DTLVS* TLV/BEI,2002
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 39,81,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,1447,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 39,81,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1447,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,1447,1999
TOXICOLOGY REVIEW
EVHPAZ 11,141,1975
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 567,227,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (100 mg/m3) (skin) DTLVS* 3,102,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (100 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (100 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (100 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (100 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 ppm (20 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 5 ppm (20 mg/m3), short term exposure limit 25 ppm (100 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 ppm (20 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (20 mg/m3), short term exposure limit 10 ppm (40 mg/m3), Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 5 ppm (20 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 10 mg/m3, Skin, Carcinogen, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 20 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 5 ppm (20 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 25 ppm (100 mg/m3), Skin, JAN1993
Occupational Exposure Limit - POLAND time-weighted average 20 mg/m3, short term exposure limit 80 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 5 ppm (20 mg/m3), KTV 10 ppm (40 mg/m3), Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 ppm (20 mg/m3), KZG- week 10 ppm (40 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 25 ppm (100 mg/m3), Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 ppm (21 mg/m3), short term exposure limit 15 ppm (62 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 15 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 15 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL ACRYLATE-air Carcinogen (4.0 ppm LOQ) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 31490;
Number of Industries 42;
Total Number of Facilities 3,312;
Number of Occupations 51;
Total Number of Employees Exposed 40,491
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 31490;
Number of Industries 26;
Total Number of Facilities 2,898;
Number of Occupations 42;
Total Number of Employees Exposed 44,604;
Total Number of Female Employees Exposed 7,205


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in emulsion polymers for paints, textiles, adhesives, coatings and binders
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Esters I, 1450
NCI Carcinogenesis Studies (gavage);clear evidence:mouse,rat
OSHA ANALYTICAL METHOD #92


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946-
APTOD9 Abstracts of Papers, Society of Toxicology. Annual Meetings. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PJPPAA Polish Journal of Pharmacology and Pharmacy. (ARS Polona, POB 1001, 00-068 Warsaw 1, Poland) V.25-44, 1973-92. For publisher information, see PJPAE3
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in emulsion polymers for paints, textiles, adhesives, coatings and binders

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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