The Registry of Toxic Effects of Chemical Substances
Acrylic acid, methyl ester |
UPDATE: November 2004 | MW: 86.10 | MF: C4H6O2 |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
eye rat | 578 ppm/49 hour- intermittent | N/R | JIHTAB 31,317,1949 |
eye rabbit | 100 mg | severe | AJOPAA 29,1363,1946 |
eye rabbit | 100 mg/24 hour | moderate | 85JCAE -,368,1986 |
skin rabbit | 1,00%/1 minute immersion | moderate | JIHTAB 31,317,1949 |
skin rabbit | 10 mg/24 hour open irritation test | moderate | JIHTAB 30,63,1948 |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
cytogenetic analysis | hamster fibroblast | 189 ppm | ESKHA5 (102),77,1984 |
cytogenetic analysis | hamster lung | 6,500 痢/L | GMCRDC 27,95,1981 |
cytogenetic analysis | mouse lymphocyte | 22 mg/L | ENMUDM 8(Suppl 6),4,1986 |
mutation in microorganisms | mouse lymphocyte | 22 mg/L (+enzymatic activation step) | ENMUDM 8(Suppl 6),4,1986 |
micronucleus test |
intraperitoneal mouse | 37,500 痢/kg | MUREAV 135,189,1984 |
mutation in mammalian somatic cells | mouse lymphocyte | 14 mg/L | EMMUEG 11,49,1988 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lowest published toxic concentration: 100 ppm/6 hour (6-20 day pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | TOSCF2 48,240,1999 |
inhalation rat | lowest published toxic concentration: 100 ppm (6-20 day pregnant) |
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other effects on female | TOSCF2 48,240,1999 |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation human | lowest published toxic concentration: 75 ppm |
Olfaction: Other olfaction effects Eye: Other eye effects Lung, Thorax, or Respiration: Other changes | 34ZIAG -,75,1969 |
inhalation mouse | lethal concentration (50 percent kill): 12,800 mg/m3 | N/R | GTPZAB 23(9),55,1979 |
inhalation rat | lethal concentration (50 percent kill): 1,350 ppm/4 hour |
Olfaction: Other olfaction effects Eye: Other eye effects Lung, Thorax, or Respiration: Dyspnea | JTEHD6 16,811,1985 |
inhalation rabbit | lowest published lethal concentration: 2,522 ppm/1 hour |
Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Changes in structure or function of salivary glands | JIHTAB 31,317,1949 |
intraperitoneal mouse | lethal dose (50 percent kill): 254 mg/kg | N/R | JDREAF 51,526,1972 |
intraperitoneal rat | lethal dose (50 percent kill): 325 mg/kg | N/R | AMPMAR 36,58,1975 |
oral mouse | lethal dose (50 percent kill): 827 mg/kg | N/R | TOLED5 11,125,1982 |
oral rat | lethal dose (50 percent kill): 277 mg/kg | N/R | AMPMAR 36,58,1975 |
oral rabbit | lowest published lethal dose: 280 mg/kg |
Behavioral: Somnolence (general depressed activity) Behavioral: Tremor Lung, Thorax, or Respiration: Dyspnea | JIHTAB 31,317,1949 |
skin rabbit | lethal dose (50 percent kill): 1,243 mg/kg | N/R | JIHTAB 30,63,1948 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lowest published toxic concentration: 100 痢/m3/24 hour/14 week- continuous |
Behavioral: Muscle contraction or spasticity Kidney, Ureter, and Bladder: Other changes in urine composition Blood: Changes in spleen | GISAAA 32(10),3,1967 |
inhalation rat | lowest published toxic concentration: 71 mg/m3/3 hour/17 week- intermittent | Brain and Coverings: Recordings from specific areas of CNS | GISAAA 45(1),34,1980 |
oral rat | lowest published toxic dose: 109 gm/kg/2 year- continuous |
Behavioral: Fluid intake Kidney, Ureter, and Bladder: Changes in bladder weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TXAPA9 6,29,1964 |
skin guinea pig | lowest published toxic dose: 5 pph/12 week- intermittent | Skin: After topical application: Cutaneous sensitization (experimental) | CODEDG 9,55,1983 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 2 ppm (skin, sen) | DTLVS* TLV/BEI,2003 |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | Not Classifiable as a Human Carcinogen | DTLVS* TLV/BEI,2003 |
International Agency for Research on Cancer (IARC) Cancer Review | Human No Adequate Data | IMEMDT 39,99,1986 |
International Agency for Research on Cancer (IARC) Cancer Review | Human No Adequate Data | IMEMDT 71,1489,1999 |
International Agency for Research on Cancer (IARC) Cancer Review | Animal Inadequate Evidence | IMEMDT 39,99,1986 |
International Agency for Research on Cancer (IARC) Cancer Review | Animal Inadequate Evidence | IMEMDT 71,1489,1999 |
International Agency for Research on Cancer (IARC) Cancer Review | Group 3 | IMEMDT 71,1489,1999 |
TOXICOLOGY REVIEW |
| EVHPAZ 11,141,1975 |
TOXICOLOGY REVIEW |
| CMTVAS 10(3),49,1973 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Mine Safety and Health Administration (MSHA) STANDARD - air | time-weighted average 10 ppm (35 mg/m3) (skin) | DTLVS* 3,154,1971 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8 hour time-weighted average 10 ppm (35 mg/m3) (skin) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8 hour time-weighted average 10 ppm (35 mg/m3) (skin) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8 hour time-weighted average 10 ppm (35 mg/m3) (skin) | CFRGBR 29,1915.1000,1993 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8 hour time-weighted average 10 ppm (35 mg/m3) (skin) | CFRGBR 41,50-204.50,1994 |
Occupational Exposure Limit - AUSTRALIA | time-weighted average 10 ppm (35 mg/m3), Skin, JAN1993 | |
Occupational Exposure Limit - AUSTRIA | MAK 5 ppm (18 mg/m3), JAN1999 | |
Occupational Exposure Limit - BELGIUM | time-weighted average 10 ppm (35 mg/m3), Skin, JAN1993 | |
Occupational Exposure Limit - DENMARK | time-weighted average 10 ppm (35 mg/m3), Skin, JAN1999 | |
Occupational Exposure Limit - FINLAND | time-weighted average 10 ppm (35 mg/m3), short term exposure limit 20 ppm (70 mg/m3), Skin, JAN1993 | |
Occupational Exposure Limit - FRANCE | VME 10 ppm (35 mg/m3), VLE 15 ppm (50 mg/m3), JAN1999 | |
Occupational Exposure Limit - GERMANY | MAK 5 ppm (18 mg/m3), JAN1999 | |
Occupational Exposure Limit - HUNGARY | time-weighted average 20 mg/m3, short term exposure limit 40 mg/m3, Skin, JAN1993 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 18 mg/m3, Skin, 2003 | |
Occupational Exposure Limit - NORWAY | time-weighted average 10 ppm (35 mg/m3), JAN1999 | |
Occupational Exposure Limit - THE PHILIPPINES | time-weighted average 10 ppm (35 mg/m3), Skin, JAN1993 | |
Occupational Exposure Limit - POLAND | MAC(time-weighted average) 20 mg/m3, MAC(short term exposure limit) 70 mg/m3, JAN1999 | |
Occupational Exposure Limit - RUSSIA | short term exposure limit 5 mg/m3, JAN1993 | |
Occupational Exposure Limit - SWEDEN | NGV 10 ppm (35 mg/m3), KTV 15 ppm (50 mg/m3), Skin, JAN1999 | |
Occupational Exposure Limit - SWITZERLAND | MAK- week 5 ppm (18 mg/m3), KZG- week 10 ppm (36 mg/m3), Skin, JAN1999 | |
Occupational Exposure Limit - TURKEY | time-weighted average 10 ppm (35 mg/m3), Skin, JAN1993 | |
Occupational Exposure Limit - UNITED KINGDOM | time-weighted average 10 ppm (36 mg/m3), SEP2000 | |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; Not Classifiable as a Human Carcinogen | |
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ACRYLATE-air | 10 hour time-weighted average 10 ppm (Sk) | NIOSH* DHHS #92-100,1992 |
National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 46450; Number of Industries 22; Total Number of Facilities 931; Number of Occupations 14; Total Number of Employees Exposed 11,809 | |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 46450![]() Number of Industries 6; Total Number of Facilities 129; Number of Occupations 16; Total Number of Employees Exposed 9,762; Total Number of Female Employees Exposed 3,877 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE | FEREAC 47,26992,82 |
Used in production of acrylates, copolymers, barrier resins and surfactants for shampoos | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
On EPA IRIS database | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NIOSH Analytical Method, 1994: Methyl acrylate, 1459 | |
OSHA ANALYTICAL METHOD #92 |
REFERENCES: | |
CODEN |
REFERENCE |
34ZIAG | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 |
85JCAE | "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 |
AJOPAA | American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- |
AMPMAR | Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.7- 1946- |
CFRGBR | Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) |
CMTVAS | Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963- |
CODEDG | Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975- |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
EMMUEG | Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- |
ENMUDM | Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. |
ESKHA5 | Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- |
EVHPAZ | EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- |
FEREAC | Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- |
GISAAA | Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- |
GMCRDC | Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- |
GTPZAB | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI |
IMEMDT | IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- |
JDREAF | Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919- |
JIHTAB | Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. |
JTEHD6 | Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
TOLED5 | Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- |
TOSCF2 | Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998- |
TXAPA9 | Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- |