The Registry of Toxic Effects of Chemical Substances

Acrylic acid, 2 - cyano - , methyl ester

RTECS #: AS7000000

CAS #: 137-05-3

UPDATE: May 2004 MW: 111.11 MF: C5H5NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2 - Cyanoacrylic acid, methyl ester
  2. Adhere
  3. Coapt
  4. Cyanolit
  5. Eastman 910
  6. Eastman 910 adhesive
  7. Eastman 910 monomer
  1. Mecrilat
  2. Mecrylate
  3. Methyl 2 - cyanoacrylate
  4. Methyl 2 - cyanoacrylate (ACGIH)
  5. Methyl alpha - cyanoacrylate
  6. Methyl cyanoacrylate
  7. alpha - Cyanoacrylic acid methyl ester


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		4 ppm N/R AIHAAP 29,558,1968
skin
rabbit 		500 µg/4 hour severe IJTOFN 16(Suppl 2),40,1997


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 100 µg/plate (+enzymatic activation step) ENMUDM 9(Suppl 9),1,1987
mutation in microorganisms Salmonella typhimurium 300 µg/plate (-enzymatic activation step) MUREAV 188,97,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratesticular
monkey 		lowest published toxic dose: 100 mg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) FESTAS 39(Suppl),441,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 101 ppm/6 hour N/R 85INA8 6,965,1991
oral
rat 		lethal dose (50 percent kill): 1,600 mg/kg N/R 85INA8 6,965,1991
skin
guinea pig 		lethal dose (50 percent kill): >10,959 mg/kg N/R 85INA8 6,965,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 31,300 ppb/6 hour/12 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** OTS0518526-1


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.2 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 2 ppm (8 mg/m3) DTLVS* 3,162,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (8 mg/m3), short term exposure limit 4 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 2 ppm (8 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (9.1 mg/m3), short term exposure limit 4 ppm (18 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (8 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 2 ppm (9 mg/m3), short term exposure limit 4 ppm (18 mg/m3), Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 2 ppm (8 mg/m3), VLE 4 ppm (16 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 2 ppm (8 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 2 ppm (8 mg/m3), JAN1999
Occupational Exposure Limit - SWEDEN NGV 2 ppm (9 mg/m3), KTV 4 ppm (18 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 2 ppm (9 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 0.3 ppm (1.4 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.2 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.2 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL 2-CYANOACRYLATE-air 10 hour time-weighted average 2 ppm;
short term exposure limit 4 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4755;
Number of Industries 25;
Total Number of Facilities 895;
Number of Occupations 25;
Total Number of Employees Exposed 18,406
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4755;
Number of Industries 46;
Total Number of Facilities 1,434;
Number of Occupations 51;
Total Number of Employees Exposed 51,367;
Total Number of Female Employees Exposed 22,918


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in production of coatings and textiles
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #ID-55


REFERENCES:

CODEN
REFERENCE
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used in production of coatings and textiles

NIOSH PROFILE (ACRYLIC ACID and ESTERS), SRC, 12/79

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Primary Irritant

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