The Registry of Toxic Effects of Chemical Substances

Acrylic acid

RTECS #: AS4375000

CAS #: 79-10-7

UPDATE: November 2004 MW: 72.07 MF: C3H4O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Acroleic acid
  2. Acrylic acid, glacial
  3. Ethylenecarboxylic acid
  4. Glacial acrylic acid
  5. Kyselina akrylova (Czech)
  6. RCRA waste number U008
  1. Vinylformic acid
  2. Acrylic acid (ACGIH)
  3. Propene acid
  4. Propenoic acid
  5. 2 - Propenoic acid (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		1 mg severe UCDS** 2/2/1965
eye
rabbit 		250 µg/24 hour severe 85JCAE -,309,1986
skin
rabbit 		500 mg open irritation test severe UCDS** 2/2/1965
skin
rabbit 		5 mg/24 hour severe 85JCAE -,309,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 116 mg/L FCTOD7 30,505,1992
cytogenetic analysis mouse lymphocyte 450 mg/L EMMUEG 11,49,1988
mutation in mammalian somatic cells mouse lymphocyte 500 mg/L EMMUEG 11,49,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 300 ppm (6-20 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects on female 		TOSCF2 48,240,1999
intraperitoneal
rat 		lowest published toxic dose: 14,340 µg/kg (5-15 day pregnant) Reproductive: Other developmental abnormalities JDREAF 51,1632,1972
intraperitoneal
rat 		lowest published toxic dose: 7,329 µg/kg (5-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		JDREAF 51,1632,1972
oral
rat 		lowest published toxic dose: 169 gm/kg (13 week male/13 week prior to copulation-3 week after birth) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical 		DCTODJ 6,1,1983
oral
rat 		lowest published toxic dose: 43,680 mg/kg (multigeneration) Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTIS** OTS0573007


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 2,912 mg/kg/52 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		CBINA8 61,189,1987
skin
mouse 		lowest published toxic dose: 37,440 mg/kg/78 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia 		EPASR* 8EHQ-0386-0592
skin
mouse 		toxic dose : 37,440 mg/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		EPASR* 8EHQ-0386-0592


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
monkey 		lethal concentration : >75 ppm/6 hour Olfaction: Deviated nasal septum

Olfaction: Ulcerated nasal septum 		TOXID9 36(1,pt2),113,1997
inhalation
mouse 		lethal concentration (50 percent kill): 5,300 mg/m3/2 hour N/R 85GMAT -,16,1982
inhalation
rat 		lowest published lethal concentration: 4,000 ppm/4 hour N/R TXAPA9 28,313,1974
intraperitoneal
mouse 		lethal dose (50 percent kill): 144 mg/kg N/R YKKZAJ 104,793,1984
intraperitoneal
rat 		lethal dose (50 percent kill): 22 mg/kg N/R JDREAF 51,1632,1972
oral
mouse 		lethal dose (50 percent kill): 2,400 mg/kg Tumorigenic: Active as anti-cancer agent BIJOAK 34,1196,1940
oral
rat 		lethal dose (50 percent kill): 33,500 µg/kg N/R 85GMAT -,16,1982
subcutaneous
mouse 		lethal dose (50 percent kill): 1,590 mg/kg N/R JPPMAB 21,85,1969
skin
rabbit 		lethal dose (50 percent kill): 280 µL/kg N/R TXAPA9 28,313,1974
unreported route
mouse 		lethal dose (50 percent kill): 830 mg/kg N/R GISAAA 49(10),64,1984
unreported route
rat 		lethal dose (50 percent kill): 1,250 mg/kg N/R GISAAA 49(10),64,1984
unreported route
rabbit 		lethal dose (50 percent kill): 250 mg/kg N/R GISAAA 49(10),64,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 223 ppm/6 hour/2 week- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 1,271,1981
inhalation
mouse 		lowest published toxic concentration: 25 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 1,271,1981
inhalation
mouse 		lowest published toxic concentration: 225 ppm/6 hour/10 day- intermittent Olfaction: Other olfaction effects

Behavioral: Muscle contraction or spasticity

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0555707
inhalation
rat 		lowest published toxic concentration: 223 ppm/6 hour/2 week- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FAATDF 1,271,1981
inhalation
rat 		lowest published toxic concentration: 75 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects FAATDF 1,271,1981
inhalation
rat 		lowest published toxic concentration: 225 ppm/6 hour/10 day- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0555707
oral
rat 		lowest published toxic dose: 22,500 mg/kg/90 day- continuous Behavioral: Fluid intake

Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Changes in testicular weight 		DCTODJ 6,1,1983
skin
guinea pig 		lowest published toxic dose: 5 pph/12 week- intermittent Skin: After topical application: Cutaneous sensitization (experimental) CODEDG 9,55,1983


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal No Adequate Data IMEMDT 19,47,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal No Adequate Data IMEMDT 71,1223,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 19,47,1979
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1223,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1223,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 ppm (30 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 10 ppm (29 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2 ppm (5.9 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 10 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK CANNOT BE ESTABLISHED, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 10 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5.9 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.03 mg/m3, Skin, Carcinogen, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 ppm (30 mg/m3), short term exposure limit 20 ppm (60 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACRYLIC ACID-air 10 hour time-weighted average 2 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 03570;
Number of Industries 44;
Total Number of Facilities 1,679;
Number of Occupations 41;
Total Number of Employees Exposed 28,576
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 03570;
Number of Industries 74;
Total Number of Facilities 4,826;
Number of Occupations 67;
Total Number of Employees Exposed 96,535;
Total Number of Female Employees Exposed 28,146


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of plastics, acrylates, polyacrylic acids, polymers and resins
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8796
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #28


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

Used in manufacture of plastics, acrylates, polyacrylic acids, polymers and resins

NIOSH PROFILE (ACIDS, ORGANIC), SRI, 2/77

NIOSH PROFILE (ACRYLIC ACID and ESTERS), SRC, 12/79

NIOSH PROFILE (ACIDS, ORGANIC), SRC, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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