The Registry of Toxic Effects of Chemical Substances

Acrolein

RTECS #: AS1050000

CAS #: 107-02-8

UPDATE: May 2005 MW: 56.07 MF: C3H4O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Acraldehyde
  2. Acraldehydeacroleina (Italian)
  3. Acroleina (Italian)
  4. Acrolein (ACGIH:OSHA)
  5. Acroleine (Dutch, French)
  6. Acrylaldehyde
  7. Acrylic aldehyde
  8. Aqualin
  9. Aqualine
  10. Crolean
  11. Ethylene aldehyde
  12. Magnacide B
  13. Magnacide H
  14. RCRA waste number P003
  1. Slimicide
  2. trans - Acrolein
  3. Acrylaldehyd (German)
  4. Akrolein (Czech)
  5. Akroleina (Polish)
  6. Aldehyde acrylique (French)
  7. Aldeide acrilica (Italian)
  8. Allyl aldehyde
  9. Biocide
  10. Magnacide
  11. NSC 8819
  12. Prop - 2 - en - 1 - al
  13. 2 - Propenal


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		500 ppb/12 minute N/R IAPWAR 4,79,1961
eye
rabbit 		1 mg severe UCDS** 6/18/1971
eye
rabbit 		50 µg/24 hour severe 85JCAE -,268,1986
skin
human 		1% VCVGK* -,386,1994
skin
rabbit 		5 mg open irritation test severe UCDS** 6/18/1971
skin
rabbit 		2 mg/24 hour severe 85JCAE -,268,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct Escherichia coli 286 nmol/L ARTODN 46,277,1980
DNA adduct human fibroblast 100 µmol/L CRNGDP 12,1483,1991
DNA adduct mammal (species unspecified) lymphocyte 58 gm/L/3 hour CNREA8 44,990,1984
DNA damage human other cell types 30 µmol/L CNREA8 48,1717,1988
DNA damage human lung 0.15 pmol/well/1 hour TOLED5 132,27,2002
DNA damage rat other cell types 30 mmol/L ARTODN 58,67,1985
DNA inhibition mammal (species unspecified) lymphocyte 80 µmol/L FEBLAL 30,286,1973
DNA inhibition intraperitoneal
rat 		500 µg/kg BICMBE 53,243,1971
mutation in microorganisms Escherichia coli 320 nmol/plate MUREAV 516,81,2002
mutation in microorganisms Salmonella typhimurium 50 µg/plate (+enzymatic activation step) ENMUDM 5(Suppl 1),3,1983
mutation in microorganisms Salmonella typhimurium 50 µg/plate (-enzymatic activation step) NTPTB* JAN1982
mutation in mammalian somatic cells hamster lung 500 nmol/L CRNGDP 11,497,1990
mutation in mammalian somatic cells human fibroblast 200 nmol/L MUREAV 209,17,1988
other mutation test systems intraperitoneal
rat 		500 µg/kg BICMBE 53,243,1971
sister chromatid exchange hamster ovary 10 µmol/L CGCGBR 26,108,1980
sister chromatid exchange unreported route
hamster 		1.5 mg/kg VCVGK* -,385,1994
sister chromatid exchange human lymphocyte 5 µmol/L CNREA8 46,203,1986
sex chromosome loss and nondisjunction parenteral
Drosophila melanogaster 		3 mmol/L MUREAV 260,247,1991
specific locus test oral
Drosophila melanogaster 		5 mmol/L MUREAV 260,247,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
rabbit 		lowest published toxic dose: 6 mg/kg (9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) ARZNAD 30,2080,1980
oral
rat 		lowest published toxic dose: 840 mg/kg (multigeneration) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FAATDF 19,228,1992


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 1,570 mg/m3/2 hour N/R APTOA6 6,299,1950
inhalation
cat 		lowest published toxic concentration: 250 mg/m3 Eye: Lacrimation

Behavioral: General anesthetic

Gastrointestinal: Changes in structure or function of salivary glands 		VCVGK* -,383,1984
inhalation
cat 		lowest published toxic concentration: 200 mg/m3 Lung, Thorax, or Respiration: Other changes VCVGK* -,383,1984
inhalation
cat 		lowest published lethal concentration: 1,500 mg/m3/2 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Liver: Multiple effects

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,383,1984
inhalation
child 		lowest published toxic concentration: 300 ppb/2 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Other changes 		NPMDAD 8,2469,1979
inhalation
guinea pig 		lowest published lethal concentration: 24 mg/m3/6 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema 		BMJOAE 2,913,1956
inhalation
guinea pig 		lethal concentration (50 percent kill): 10.5 ppm/6 hour Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Respiratory depression 		VCVGK* -,383,1984
inhalation
hamster 		lowest published lethal concentration: 1,000 ppm/10 minute Eye: Lacrimation

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Changes in structure or function of salivary glands 		SAIGBL 19,367,1977
inhalation
hamster 		lethal concentration (50 percent kill): 25.4 ppm/4 hour N/R VCVGK* -,383,1984
inhalation
human 		lowest published lethal concentration: 5,500 ppb N/R 34ZIAG -,73,1969
inhalation
human 		lowest published lethal concentration: 153 ppm/10 minute N/R NTIS** PB214-270
inhalation
human 		lowest published lethal concentration: 350 mg/m3/10 minute N/R VCVGK* -,384,1984
inhalation
human 		lowest published toxic concentration: 7 mg/m3 Eye: Lacrimation

Lung, Thorax, or Respiration: Respiratory depression 		VCVGK* -,384,1984
inhalation
human 		lowest published toxic concentration: 2 mg/m3/2 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVGK* -,384,1984
inhalation
human 		lowest published toxic concentration: 0.6 mg/m3/5 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVGK* -,384,1984
inhalation
human 		lowest published toxic concentration: 0.8 ppm Lung, Thorax, or Respiration: Dyspnea VCVGK* -,384,1984
inhalation
human 		lowest published toxic concentration: 0.3 ppm Lung, Thorax, or Respiration: Cough VCVGK* -,384,1984
inhalation
human 		lowest published toxic concentration: 0.14 ppm/2 minute Eye: Conjunctiva irritation VCVGK* -,384,1984
inhalation
man 		lowest published toxic concentration: 1 ppm Eye: Lacrimation BMJOAE 2,913,1956
inhalation
mouse 		lethal concentration (50 percent kill): 66 ppm/6 hour N/R IAANBS 26,281,1970
inhalation
mouse 		lethal concentration (50 percent kill): 875 ppm/1 minute Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Respiratory depression 		VCVGK* -,383,1984
inhalation
mouse 		lethal concentration (50 percent kill): 175 ppm/10 minute Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Respiratory depression 		VCVGK* -,383,1984
inhalation
mouse 		lethal concentration (50 percent kill): 152 mg/m3/6 hour Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Respiratory depression 		VCVGK* -,383,1984
inhalation
mouse 		lowest published lethal concentration: 200 mg/m3 N/R VCVGK* -,383,1984
inhalation
mouse 		lowest published lethal concentration: 650 mg/m3 Lung, Thorax, or Respiration: Other changes VCVGK* -,383,1984
inhalation
mouse 		lowest published toxic concentration: 1.7 ppm/10 minute Lung, Thorax, or Respiration: Respiratory depression VCVGK* -,383,1984
inhalation
rat 		lethal concentration (50 percent kill): 18 mg/m3/4 hour N/R CUTOEX 1,47,1993
inhalation
rat 		lethal concentration (50 percent kill): 131 ppm/30 minute Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Respiratory depression 		VCVGK* -,383,1984
inhalation
rat 		lethal concentration (50 percent kill): 8 ppm/4 hour Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Lung, Thorax, or Respiration: Respiratory depression 		VCVGK* -,383,1984
inhalation
rat 		lowest published toxic concentration: 23 ppm Lung, Thorax, or Respiration: Respiratory depression VCVGK* -,383,1984
inhalation
rat 		lowest published toxic concentration: 2.5 ppm/4 hour Vascular: Other changes VCVGK* -,383,1984
inhalation
rabbit 		lowest published lethal concentration: 24 mg/m3/6 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema 		BMJOAE 2,913,1956
inhalation
rabbit 		lethal concentration (50 percent kill): 10.5 ppm/6 hour N/R VCVGK* -,383,1984
intraperitoneal
mouse 		lethal dose (50 percent kill): 9,008 µg/kg N/R NCISP* JAN1986
intraperitoneal
rat 		lethal dose (50 percent kill): 4 mg/kg N/R TXAPA9 71,84,1983
intravenous
cat 		lowest published lethal dose: 15 mg/kg Blood: Other changes APTOA6 8,275,1952
intravenous
rat 		lowest published toxic dose: 3 mg/kg Gastrointestinal: Other changes

Blood: Changes in other cell count (unspecified) 		VCVGK* -,384,1984
intravenous
rat 		lowest published toxic dose: 0.5 mg/kg Vascular: BP lowering not characterized in autonomic section VCVGK* -,384,1984
intravenous
rat 		lowest published toxic dose: 0.5 mg/kg Vascular: BP elevation not characterized in autonomic section VCVGK* -,384,1984
oral
human 		lowest published lethal dose: 140 mg/kg N/R VCVGK* -,384,1984
oral
mammal (species unspecified) 		lowest published lethal dose: 10 mg/kg N/R AJHYA2 29,32,1939
oral
mouse 		lethal dose (50 percent kill): 13,900 µg/kg Behavioral: Somnolence (general depressed activity)

Skin and Appendages: Other: Hair

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0533812
oral
mouse 		lethal dose (50 percent kill): 28 mg/kg N/R VCVGK* -,383,1984
oral
rat 		lethal dose (50 percent kill): 26 mg/kg N/R GISAAA 58(10),4,1993
oral
rabbit 		lethal dose (50 percent kill): 7 mg/kg N/R PCOC** -,1,1966
subcutaneous
guinea pig 		lowest published lethal dose: 178 µg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes

Lung, Thorax, or Respiration: Dyspnea 		AEXPBL 43,351,1900
subcutaneous
mouse 		lethal dose (50 percent kill): 30 mg/kg Behavioral: General anesthetic

Liver: Fatty liver degeneration 		APTOA6 6,299,1950
subcutaneous
mouse 		lowest published lethal dose: 400 mg/kg Behavioral: Excitement

Vascular: Shock 		VCVGK* -,383,1984
subcutaneous
rat 		lethal dose (50 percent kill): 50 mg/kg Behavioral: General anesthetic

Liver: Fatty liver degeneration 		APTOA6 6,299,1950
subcutaneous
rabbit 		lowest published lethal dose: 250 mg/kg Lung, Thorax, or Respiration: Dyspnea AEXPBL 43,351,1900
subcutaneous
rabbit 		lethal dose (50 percent kill): 164 mg/kg N/R VCVGK* -,383,1984
skin
rabbit 		lethal dose (50 percent kill): 200 mg/kg N/R UCDS** 6/18/1971
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 45 mg/kg N/R 30ZDA9 -,111,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 3,700 ppb/8 hour/6 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi TXAPA9 17,726,1970
inhalation
hamster 		lowest published toxic concentration: 4,900 ppb/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight 		TXCYAC 9,47,1978
inhalation
hamster 		lowest published toxic concentration: 4 ppm/7 hour/52 week- intermittent Brain and Coverings: Changes in brain weight

Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight 		JTEHD6 3,379,1977
inhalation
hamster 		lowest published toxic concentration: 4.9 ppm/13 week- intermittent Blood: Changes in other cell count (unspecified)

Blood: Changes in erythrocyte (RBC) count 		VCVGK* -,385,1994
inhalation
monkey 		lowest published toxic concentration: 3,700 ppb/8 hour/6 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 17,726,1970
inhalation
mouse 		lowest published toxic concentration: 6 ppm/6 hour/2 week- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGK* -,384,1994
inhalation
mouse 		lowest published toxic concentration: 25 ppm/6 hour/2 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,384,1994
inhalation
rat 		lowest published toxic concentration: 4 ppm/6 hour/62 day- intermittent Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXCYAC 34,139,1985
inhalation
rat 		lowest published toxic concentration: 4,900 ppb/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Endocrine: Changes in adrenal weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXCYAC 9,47,1978
inhalation
rat 		lowest published toxic concentration: 510 µg/m3/24 hour/9 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GISAAA 31(1),9,1966
inhalation
rat 		lowest published toxic concentration: 3 ppm/6 hour/3 week- intermittent Olfaction: Other olfaction effects

Endocrine: Changes in spleen weight 		TOLED5 39,189,1987
inhalation
rat 		lowest published toxic concentration: 1.52 ppm/61 day- continuous Lung, Thorax, or Respiration: Other changes VCVGK* -,384,1994
inhalation
rat 		lowest published toxic concentration: 0.51 ppm/61 day- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi VCVGK* -,384,1994
inhalation
rat 		lowest published toxic concentration: 0.55 ppm/10 day- continuous Lung, Thorax, or Respiration: Cough

Immunological Including Allergic: Decreased immune response 		VCVGK* -,384,1994
inhalation
rat 		lowest published toxic concentration: 4 ppm/6 hour/62 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,385,1994
inhalation
rat 		lowest published toxic concentration: 1.4 ppm/6 hour/62 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes 		VCVGK* -,385,1994
inhalation
rat 		lowest published toxic concentration: 1.52 mg/m3/60 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVGK* -,385,1994
inhalation
rat 		lowest published toxic concentration: 0.51 mg/m3/60 day- continuous Behavioral: Alteration of classical conditioning

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Metabolism (intermediary): Porphyrin including bile pigments 		VCVGK* -,385,1994
inhalation
rat 		lowest published toxic concentration: 0.15 mg/m3/60 day- continuous Blood: Changes in leukocyte (WBC) count VCVGK* -,385,1994
inhalation
rabbit 		lowest published toxic concentration: 4,900 ppb/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight 		TXCYAC 9,47,1978
intratracheal
chicken 		lowest published toxic dose: 200 ppm/5 minute/3 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi VCVGK* -,385,1994
oral
rat 		lowest published toxic dose: 113 mg/kg/45 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		IJEBA6 35,1373,1997
oral
rat 		lowest published toxic dose: 91 mg/kg/26 week- intermittent Liver: Liver function tests impaired

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,385,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.1 ppm (skin) DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 19,479,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 36,133,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 36,133,1985
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 63,337,1995
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,78,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 63,339,1995
TOXICOLOGY REVIEW
EVHPAZ 11,163,1975
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW
MUREAV 47,115,1978
TOXICOLOGY REVIEW
MUREAV 5441152003
TOXICOLOGY REVIEW
MUREAV 567,347,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,159,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.25 mg/m3) DTLVS* 3,5,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 ppm (0.25 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 ppm (0.25 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 ppm (0.25 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 ppm (0.25 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 ppm (0.25 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.25 mg/m3), short term exposure limit 0.3 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 ppm (0.25 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.23 mg/m3), short term exposure limit 0.3 ppm, JAN1993
Occupational Exposure Limit - FINLAND short term exposure limit 0.1 ppm (0.25 mg/m3), Skin, JAN1993
Occupational Exposure Limit - FRANCE VLE 0.1 ppm (0.25 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 ppm (0.25 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.25 mg/m3, short term exposure limit 0.5 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.05 mg/m3, 2003
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 ppm (0.23 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.25 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 ppm (0.25 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.2 mg/m3, MAC(short term exposure limit) 0.5 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.1 ppm, short term exposure limit 0.2 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.1 ppm (0.2 mg/m3), KTV 0.3 ppm (0.7 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.25 mg/m3), KZG- week 0.2 ppm (0.5 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.1 ppm (0.25 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.23 mg/m3, short term exposure limit 0.70 mg.m3, Carcinogen, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 0.1 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 0.1 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACROLEIN-air 10 hour time-weighted average 0.1 ppm;
short term exposure limit 0.3 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 03530;
Number of Industries 16;
Total Number of Facilities 845;
Number of Occupations 25;
Total Number of Employees Exposed 7,299
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 03530;
Number of Industries 4;
Total Number of Facilities 37;
Number of Occupations 18;
Total Number of Employees Exposed 1,298;
Total Number of Female Employees Exposed 5


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/91/180307/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as pharmaceutical and slimicide and in production of cosmetics and food supplements
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991
NIOSH Analytical Method, 1994: Acrolein, 2501
NIOSH Analytical Method, 1994: Aldehydes, screening, 2539
NTP Carcinogenesis studies; test completed (peer review), October 2000
OSHA ANALYTICAL METHOD #52


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
AJHYA2 American Journal of Hygiene. (Baltimore, MD) V.1-80, 1921-64. For publisher information, see AJEPAS.
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BICMBE Biochimie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53- 1971-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CGCGBR Cytogenetics and Cell Genetics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.12- 1973-
CMTVAS Cahiers de Medecine du Travail. (Association Professionnelle Belge des Medecine du Travail, rue du Bultia, 6280 Gerpinnes, Belgium) V.1- 1963-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
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Used as pharmaceutical and slimicide and in production of cosmetics and food supplements

NIOSH PROFILE (ACROLEIN), SRC, 12/79

NIOSH PROFILE (ALDEHYDES), SRC, 4/78

NIOSH PROFILE (FIREFIGHTING), FIRL, 4/78

NIOSH PROFILE (INCINERATION), FIRL, 4/78

NIOSH PROFILE (ALDEHYDES), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

ALT CAS #: 25314-61-8
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