The Registry of Toxic Effects of Chemical Substances
Acetyl chloride, dichloro - RTECS #: AO6650000
CAS #: 79-36-7
The Registry of Toxic Effects of Chemical Substances
Acetyl chloride, dichloro - |
| UPDATE: June 1998 | MW: 147.38 | MF: C2HCl3O |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
eye | rabbit
50 µg open irritation test
|
severe
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AMIHBC 4,119,1951
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skin | rabbit
2 mg/24 hour
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severe
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85JCAE -,571,1986
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
mutation in microorganisms
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Salmonella typhimurium
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1 mg/plate (+enzymatic activation step)
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EMMUEG 19(Suppl 21),2,1992
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
subcutaneous | mouse
lowest published toxic dose: 2 mg/kg/80 week- intermittent
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Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Skin and Appendages: Tumors Tumorigenic: Tumors at site of application
CNREA8 43,159,1983
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | rat
lowest published lethal concentration: 2,000 ppm/4 hour
|
N/R
|
AMIHBC 4,119,1951
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oral | rat
lethal dose (50 percent kill): 2,460 mg/kg
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N/R
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AMIHBC 4,119,1951
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skin | rabbit
lethal dose (50 percent kill): 650 µL/kg
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N/R
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AMIHBC 4,119,1951
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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REVIEWS:
ORGANIZATION
|
STANDARD
|
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
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REFERENCE
N/R
|
N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
|
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REFERENCE
N/R
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N/R
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N/R
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
85JCAE
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"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986
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AMIHBC
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AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54.
For publisher information, see AEHLAU.
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CNREA8
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Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA
19106) V.1- 1941-
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EMMUEG
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Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY
10003) V.10- 1987-
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