The Registry of Toxic Effects of Chemical Substances

Acetyl chloride, chloro -

RTECS #: AO6475000

CAS #: 79-04-9

UPDATE: November 2004 MW: 112.94 MF: C2H2Cl2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Chloracetyl chloride
  2. Chlorid kyseliny chloroctove (Czech)
  3. Chloroacetic acid chloride
  4. Chloroacetic chloride
  1. Chloroacetyl chloride
  2. Chloroacetyl chloride (ACGIH)
  3. Chlorure de chloracetyle (French)
  4. Monochloroacetyl chloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 1,300 ppm/2 hour N/R 85INA8 5,123(89),1986
inhalation
rat 		lethal concentration (50 percent kill): 660 ppm/1 hour N/R NTIS** OTS0555574
intravenous
mouse 		lethal dose (50 percent kill): 32 mg/kg N/R CSLNX* NX#04538
oral
mouse 		lethal dose (50 percent kill): 220 mg/kg N/R GISAAA 54(2),90,1989
oral
rat 		lethal dose (50 percent kill): 208 mg/kg N/R 85INA8 5,123(89),1986
skin
rat 		lethal dose (50 percent kill): 662 mg/kg Skin: After topical application: Corrosive GISAAA 54(2),90,1989
skin
rabbit 		lowest published lethal dose: 316 mg/kg N/R 85INA8 5,123(89),1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
hamster 		lowest published toxic concentration: 5 ppm/6 hour/4 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** OTS0536493
inhalation
mouse 		lowest published toxic concentration: 5 ppm/6 hour/4 week- intermittent Olfaction: Other olfaction effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0536493
inhalation
rat 		lowest published toxic concentration: 1 ppm/6 hour/4 week- intermittent Olfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0536493


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm (skin) DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm (skin);short term exposure limit 0.15 ppm (skin) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 0.15 ppm (skin) DTLVS* TLV/BEI,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.05 ppm (0.2 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 ppm (0.23 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.05 ppm (0.2 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.05 ppm (0.2 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.05 ppm (0.2 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.2 mg/m3, 2003
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 ppm (0.24 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 0.05 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 0.15 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 0.15 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLOROACETYL CHLORIDE-air 10 hour time-weighted average 0.05 ppm NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: A1131;
Number of Industries 1;
Total Number of Facilities 33;
Number of Occupations 1;
Total Number of Employees Exposed 66
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: A1131;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 5;
Total Number of Employees Exposed 4,354;
Total Number of Female Employees Exposed 729


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

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