The Registry of Toxic Effects of Chemical Substances

Acetyl chloride

RTECS #: AO6390000

CAS #: 75-36-5

UPDATE: September 1998 MW: 78.50 MF: C2H3ClO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Acetic acid, chloride
  2. Acetic chloride
  1. Ethanoyl chloride
  2. RCRA waste number U006


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
gene conversion and mitotic recombination oral
Drosophila melanogaster 		62,500 µmol/L CRNGDP 17,1083,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 2 ppm/1 minute Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes 		TGNCDL 2,28,1961
oral
rat 		lethal dose (50 percent kill): 910 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Excitement

Lung, Thorax, or Respiration: Other changes 		GTPZAB 32(3),48,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81687;
Number of Industries 4;
Total Number of Facilities 96;
Number of Occupations 7;
Total Number of Employees Exposed 931
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81687;
Number of Industries 3;
Total Number of Facilities 40;
Number of Occupations 5;
Total Number of Employees Exposed 2,534;
Total Number of Female Employees Exposed 575


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an acetylating agent and in testing for water and/or cholesterol in organic liquids
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
TGNCDL "Handbook of Organic Industrial Solvents," 2nd ed., Chicago, National Assoc. of Mutual Casualty Companies, 1961

Used as an acetylating agent and in testing for water and/or cholesterol in organic liquids

RTECS Compound Description:
   Mutagen
   Human Data

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