The Registry of Toxic Effects of Chemical Substances

o - Acetotoluidide, 2 - chloro - 6' - ethyl - N - (2 - methoxy - 1 - methylethyl) -

RTECS #: AN3430000

CAS #: 51218-45-2

UPDATE: May 2005 MW: 283.83 MF: C15H22ClNO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. STANDARDS AND REGULATIONS:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Acetamide, 2 - chloro - N - (6 - ethyl - o - tolyl) - N - (2 - methoxy - 1 - methylethyl) -
  2. CGA - 24705
  3. alpha - Chlor - 6' - aethyl - N - (2 - methoxy - 1 - methylaethyl) - acet - o - toluidin (German)
  4. 2 - Chloro - 6' - ethyl - N - (2 - methoxy - 1 - methylethyl) acet - o - toluidide
  5. alpha - Chloro - 2' - ethyl - 6' - methyl - N - (1 - methyl - 2 - methoxyethyl) - acetanilide
  6. 2 - Chloro - N - (2 - ethyl - 6 - methylphenyl) - N - (2 - methoxy - 1 - methylethyl) acetamide
  7. Codal
  8. Cotoran multi
  9. Dual
  1. Dual 720EC
  2. Dual Triple
  3. 2 - Ethyl - 6 - methyl - 1 - N - (2 - methoxy - 1 - methylethyl) chloroacetanilide
  4. 2 - Etylo - 6 - metylo - N - (1' - metylo - 2' - metoksyetylo) chloroacetanilid (Polish)
  5. Metachlore
  6. Metelilachlor
  7. Metolachlor
  8. Ontrack 8E
  9. 2 - Aethyl - 6 - methyl - N - (1 - methyl - 2 - methoxyaethyl) - chloracetanilid (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg mild NNGADV 14,103,1989
skin
rabbit 		334 mg open irritation test mild CIGET* -,-,1977


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 100 µg/L MUREAV 281,295,1992
mutation in microorganisms Salmonella typhimurium 10 µg/plate (-enzymatic activation step) MUREAV 136,233,1984
gene conversion and mitotic recombination Saccharomyes cerevisiae 1 µg/plate MUREAV 136,233,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		NNGADV 14,103,1989
unreported route
mammal (species unspecified) 		lowest published toxic dose: 76 mg/kg (multigenerations) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) FEREAC 64,11787,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >1,750 mg/m3/4 hour N/R LITRC* TR-78-0310
intraperitoneal
mouse 		lethal dose (50 percent kill): 410 mg/kg N/R NNGADV 14,103,1989
intraperitoneal
rat 		lethal dose (50 percent kill): 620 mg/kg N/R NNGADV 14,103,1989
oral
duck 		lethal dose (50 percent kill): >2,510 mg/kg N/R FMCHA2 -,C203,1991
oral
mouse 		lethal dose (50 percent kill): 1,150 mg/kg N/R NNGADV 14,103,1989
oral
rat 		lethal dose (50 percent kill): 2,200 mg/kg N/R NNGADV 14,103,1989
subcutaneous
mouse 		lethal dose (50 percent kill): 2,400 mg/kg N/R NNGADV 14,103,1989
subcutaneous
rat 		lethal dose (50 percent kill): >9 gm/kg N/R NNGADV 14,103,1989
skin
rat 		lethal dose (50 percent kill): 3,170 mg/kg N/R MSNRD5 18,341,1979
skin
rabbit 		lethal dose (50 percent kill): >10 gm/kg N/R LITRC* TR-78-0310
unreported route
rat 		lethal dose (50 percent kill): 3,170 mg/kg N/R AGKYAU (5),138,1980


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 4,550 mg/kg/26 week- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		NNGADV 14,103,1989
oral
mouse 		lowest published toxic dose: 263 gm/kg/2 year- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NNGADV 14,103,1989
oral
rat 		lowest published toxic dose: 5,460 mg/kg/13 week- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NNGADV 14,103,1989
oral
rat 		lowest published toxic dose: 131 gm/kg/2 year- continuous Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NNGADV 14,103,1989
oral
rat 		lowest published toxic dose: 109,200 mg/kg/104 week- continuous Liver: Tumors HBPTO* 1,814,2001
oral
rat 		lowest published toxic dose: 23,310 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain FEREAC 68,15945,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE
AGKYAU Agrokhimiya. Agricultural Chemistry. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1964-
CIGET* Ciba-Geigy Toxicology Data/Indexes. (Ciba-Geigy Corp., 556 Morris Ave., Summit, NJ 07901)
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
LITRC* Literature Research Co., Translation. (Annandale, VA)
MSNRD5 Materialy Sesji Naukowej Instytutu Ochrony Roslin (Poznan). Materials of the Scientific Session of the Institute of Plant Protection. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) History not known.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-

Used as a herbicide for weed control in corn

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Primary Irritant

ALT CAS #: 63150-68-5
ALT CAS #: 94449-58-8
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