The Registry of Toxic Effects of Chemical Substances
Acetophenone, 2 - chloro - |
UPDATE: November 2004 | MW: 154.60 | MF: C8H7ClO |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
eye rabbit | 1 mg | mild | TXAPA9 17,295,1970 |
eye rabbit | 3 mg | severe | TXAPA9 17,295,1970 |
eye rabbit | 2% rinse | mild | ARTODN 34,183,1975 |
eye rabbit | 1% | VCVGK* -,463,1994 | |
skin guinea pig | 12%/6 hour open irritation test | moderate | ARTODN 40,75,1978 |
skin human | 0.5 mg/1 hour | moderate | CODEDG 86,150,1972 |
skin rat | 12%/6 hour open irritation test | moderate | ARTODN 40,75,1978 |
skin rabbit | 5 mg/24 hour | mild | TXAPA9 17,295,1970 |
skin rabbit | 12%/6 hour open irritation test | moderate | ARTODN 40,75,1978 |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
cytogenetic analysis | hamster ovary | 3 mg/L | NTPTR* NTP-TR-379,1990 |
DNA damage | rat liver | 10 痠ol/L | MUREAV 368,59,1996 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation rat | lowest published toxic concentration: 2 mg/m3/6 hour/2 year- intermittent |
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria Endocrine: Tumors Skin and Appendages: Tumors | NTPTR* NTP-TR-379,1990 |
skin mouse | lowest published toxic dose: 2,400 mg/kg/27 week- intermittent |
Tumorigenic: Neoplastic by RTECS criteria Skin and Appendages: Tumors Tumorigenic: Tumors at site of application | BJCAAI 7,482,1953 |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
eye rabbit | lowest published toxic dose: 5 pph | Eye: Corneal damage | VCVGK* -,463,1994 |
inhalation guinea pig | lowest published lethal concentration: 490 mg/m3/30 minute |
Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage | ARTODN 40,75,1978 |
inhalation human | lowest published lethal concentration: 159 mg/m3/20 minute | N/R | 34ZIAG -,163,1969 |
inhalation human | lowest published toxic concentration: 93 mg/m3/3 minute |
Eye: Lacrimation Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Dyspnea | AIHAAP 23,199,1962 |
inhalation human | lowest published toxic concentration: 20 mg/m3 |
Eye: Other eye effects Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Dyspnea | BJIMAG 29,298,1972 |
inhalation human | lowest published toxic concentration: 0.5 mg/m3/10S | Eye: Conjunctiva irritation | VCVGK* -,463,1994 |
inhalation mouse | lethal concentration (50 percent kill): 59 mg/m3 | N/R | GISAAA 58(10),4,1993 |
inhalation rat | lowest published lethal concentration: 417 mg/m3/15 minute |
Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage | ARTODN 40,75,1978 |
inhalation rabbit | lowest published lethal concentration: 465 mg/m3/20 minute |
Olfaction: Other olfaction effects Lung, Thorax, or Respiration: Acute pulmonary edema Blood: Hemorrhage | ARTODN 40,75,1978 |
intraperitoneal guinea pig | lethal dose (50 percent kill): 17 mg/kg |
Behavioral: Coma Lung, Thorax, or Respiration: Other changes Skin and Appendages: Other: Hair | ARTODN 40,75,1978 |
intraperitoneal mouse | lethal dose (50 percent kill): 60 mg/kg | N/R | NTIS** AD837-111 |
intraperitoneal rat | lethal dose (50 percent kill): 36 mg/kg |
Behavioral: Coma Lung, Thorax, or Respiration: Other changes Skin and Appendages: Other: Hair | ARTODN 40,75,1978 |
intravenous mouse | lethal dose (50 percent kill): 81 mg/kg |
Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation Kidney, Ureter, and Bladder: Other changes | ARTODN 40,75,1978 |
intravenous rat | lethal dose (50 percent kill): 41 mg/kg |
Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation Kidney, Ureter, and Bladder: Other changes | ARTODN 40,75,1978 |
intravenous rabbit | lethal dose (50 percent kill): 30 mg/kg |
Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory stimulation Kidney, Ureter, and Bladder: Other changes | ARTODN 40,75,1978 |
oral guinea pig | lethal dose (50 percent kill): 158 mg/kg |
Behavioral: Coma Lung, Thorax, or Respiration: Other changes Skin and Appendages: Other: Hair | ARTODN 40,75,1978 |
oral mouse | lethal dose (50 percent kill): 139 mg/kg | N/R | NTIS** AD837-111 |
oral rat | lethal dose (50 percent kill): 50 mg/kg | N/R | TXAPA9 17,295,1970 |
oral rabbit | lethal dose (50 percent kill): 118 mg/kg |
Behavioral: Coma Lung, Thorax, or Respiration: Other changes Skin and Appendages: Other: Hair | ARTODN 40,75,1978 |
skin guinea pig | lethal dose (50 percent kill): >1 gm/kg | N/R | NTIS** OTS0556684 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation mouse | lowest published toxic concentration: 10 mg/m3/6 hour/14 day- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-379,1990 |
inhalation mouse | lowest published toxic concentration: 87.6 mg/m3/15 minute/5 day- intermittent |
Nutritional and Gross Metabolic: Weight loss or decreased weight gain Lung, Thorax, or Respiration: Other changes Endocrine: Hyperglycemia | JAPTO* 14,411,1994 |
inhalation rat | lowest published toxic concentration: 19 mg/m3/6 hour/14 day- intermittent | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field | NTPTR* NTP-TR-379,1990 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 0.05 ppm | DTLVS* TLV/BEI,2003 |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | Not Classifiable as a Human Carcinogen | DTLVS* TLV/BEI,2003 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Mine Safety and Health Administration (MSHA) STANDARD - air | time-weighted average 0.05 ppm (0.3 mg/m3) | DTLVS* 3,48,1971 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) | 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) | CFRGBR 29,1910.1000,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) | 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) | CFRGBR 29,1926.55,1994 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) | 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) | CFRGBR 29,1915.1000,1993 |
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) | 8 hour time-weighted average 0.05 ppm (0.3 mg/m3) | CFRGBR 41,50-204.50,1994 |
Occupational Exposure Limit - AUSTRALIA | time-weighted average 0.05 ppm (0.3 mg/m3), JAN1993 | |
Occupational Exposure Limit - AUSTRIA | MAK 0.05 ppm (0.3 mg/m3), JAN1999 | |
Occupational Exposure Limit - BELGIUM | time-weighted average 0.05 ppm (0.32 mg/m3), JAN1993 | |
Occupational Exposure Limit - DENMARK | time-weighted average 0.05 ppm (0.3 mg/m3), JAN1999 | |
Occupational Exposure Limit - FINLAND | short term exposure limit 0.05 ppm (0.3 mg/m3), Skin, JAN1993 | |
Occupational Exposure Limit - FRANCE | VME 0.05 ppm (0.4 mg/m3), JAN1999 | |
Occupational Exposure Limit - NORWAY | time-weighted average 0.05 ppm (0.3 mg/m3), JAN1999 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 0.3 mg/m3, 2003 | |
Occupational Exposure Limit - SWITZERLAND | MAK- week 0.05 ppm (0.3 mg/m3), JAN1999 | |
Occupational Exposure Limit |
UNITED KINGDOM; time-weighted average 0.05 ppm (0.32 mg/m3),SEP2000 | |
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; Not Classifiable as a Human Carcinogen | |
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO alpha-CHLOROACETOPHENONE-air | 10 hour time-weighted average 0.05 ppm | NIOSH* DHHS #92-100,1992 |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: X4754![]() Number of Industries 1; Total Number of Facilities 35; Number of Occupations 4; Total Number of Employees Exposed 2,294; Total Number of Female Employees Exposed 1,412 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used as an industrial chemical | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
On EPA IRIS database | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 | |
NCI Carcinogenesis Studies (inhal);equivocal evidence:rat | |
NCI Carcinogenesis Studies (inhal);no evidence:mouse |
REFERENCES: | |
CODEN |
REFERENCE |
34ZIAG | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 |
AIHAAP | American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- |
ARTODN | Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- |
BJCAAI | British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- |
BJIMAG | British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944- |
CFRGBR | Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) |
CODEDG | Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975- |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
GISAAA | Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- |
JAPTO* | Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981- |
MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
NTIS** | National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. |
NTPTR* | National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- |
TXAPA9 | Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- |
VCVGK* | "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. |