The Registry of Toxic Effects of Chemical Substances

Acetonitrile, hydroxy -

RTECS #: AM0350000

CAS #: 107-16-4

UPDATE: July 2000 MW: 57.06 MF: C2H3NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Cyanomethanol
  2. Formaldehyde cyanohydrin
  3. Glycolic nitrile
  4. Glycolonitrile (8CI)
  5. Glyconitrile
  6. Glykolonitril (Czech)
  1. Hydroxyacetonitrile
  2. 2 - Hydroxyacetonitrile
  3. Hydroxyazetonitril (German)
  4. Hydroxymethylkyanid (Czech)
  5. Hydroxymethylnitrile
  6. USAF A - 8565


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour mild 85JCAE -,915,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published lethal concentration: 27 ppm/8 hour Eye: Lacrimation

Behavioral: Somnolence (general depressed activity) 		34ZIAG -,290,1969
inhalation
rat 		lowest published lethal concentration: 27 ppm/8 hour Eye: Lacrimation

Behavioral: Somnolence (general depressed activity) 		34ZIAG -,290,1969
intraperitoneal
mouse 		lethal dose (50 percent kill): 3 mg/kg N/R ZAARAM 19,225,1969
ocular
rabbit 		lowest published lethal dose: 13 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma 		34ZIAG -,290,1969
oral
mouse 		lethal dose (50 percent kill): 10 mg/kg N/R 34ZIAG -,290,1969
oral
rat 		lethal dose (50 percent kill): 8 mg/kg N/R ZAARAM 19,225,1969
subcutaneous
mouse 		lowest published lethal dose: 15 mg/kg N/R AIPTAK 12,447,1904
skin
rabbit 		lethal dose (50 percent kill): 5 mg/kg Skin: After topical application: Primary irritation AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - SWEDEN NGV 1 ppm (5 mg/m3), KTV 2 ppm (10 mg/m3), Skin, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 1 ppm (5 mg/m3), short term exposure limit 2 ppm, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO GLYCOLONITRILE-air ceiling concentration 2.0 ppm/15 minute NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6125;
Number of Industries 1;
Total Number of Facilities 8;
Number of Occupations 18;
Total Number of Employees Exposed 1,433


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9040
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75.

NIOSH PROFILE (NITRILES), SRC, 10/77

RTECS Compound Description:
   Primary Irritant

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