The Registry of Toxic Effects of Chemical Substances
Acetophenone |
UPDATE: May 2005 | MW: 120.16 | MF: C8H8O |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
eye rabbit | 750 痢 | severe | AJOPAA 29,1363,1946 |
skin rabbit | 10 mg/24 hour open irritation test | severe | JIHTAB 26,269,1944 |
skin rabbit | 515 mg open irritation test | mild | UCDS** 12/27/1971 |
MUTATION DATA AND REFERENCES: | |||
SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
cytogenetic analysis | hamster lung | 600 mg/L | ESKHA5 (103),64,1985 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
oral rat | lowest published toxic dose: 32 gm/kg (4 week male/10 day pregnant-3 day after birth) |
Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | TOXID9 72,76,2003 |
TUMORIGENIC DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation mammal (species unspecified) | lethal concentration (50 percent kill): 1,200 mg/m3 | N/R | GTPZAB 32(10),25,1988 |
inhalation mouse | lethal concentration (50 percent kill): 1,200 mg/m3/4 hour |
Eye: Conjunctiva irritation Behavioral: Tetany Lung, Thorax, or Respiration: Respiratory depression | VCVGK* -,461,1994 |
inhalation rat | lethal concentration : >210 ppm/8 hour | N/R | UCDS** 12/27/1971 |
intraperitoneal mouse | lethal dose (50 percent kill): 200 mg/kg | N/R | NTIS** AD277-689 |
oral mammal (species unspecified) | lethal dose (50 percent kill): 2,700 mg/kg | N/R | GTPZAB 32(10),25,1988 |
oral mouse | lethal dose (50 percent kill): 740 mg/kg | N/R | GTPZAB 26(8),53,1982 |
oral mouse | lethal dose (50 percent kill): 1,250 mg/kg |
Lung, Thorax, or Respiration: Emphysema Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,461,1994 |
oral rat | lethal dose (50 percent kill): 815 mg/kg | N/R | GTPZAB 26(8),53,1982 |
oral rat | lethal dose (50 percent kill): 2,650 mg/kg |
Lung, Thorax, or Respiration: Emphysema Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,461,1994 |
subcutaneous mouse | lowest published lethal dose: 330 mg/kg | Behavioral: Somnolence (general depressed activity) | HDTU** -,-,1933 |
skin guinea pig | lethal dose (50 percent kill): >20 mL/kg | N/R | JIHTAB 26,269,1944 |
skin mouse | lowest published lethal dose: 100 pph/4 hour | N/R | VCVGK* -,461,1994 |
skin rabbit | lethal dose (50 percent kill): 15,900 無/kg | N/R | UCDS** 12/27/1971 |
unreported route guinea pig | lethal dose (50 percent kill): 2,000 mg/kg | N/R | VCVGK* -,461,1994 |
unreported route mouse | lethal dose (50 percent kill): 533 mg/kg |
Lung, Thorax, or Respiration: Emphysema Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,461,1994 |
unreported route mouse | lowest published lethal dose: 510 mg/kg |
Lung, Thorax, or Respiration: Emphysema Liver: Other changes Kidney, Ureter, and Bladder: Other changes | VCVGK* -,461,1994 |
unreported route rabbit | lethal dose (50 percent kill): 1,760 mg/kg | N/R | VCVGK* -,461,1994 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
inhalation mammal (species unspecified) | lowest published toxic concentration: 0.7 mg/m3/75 day- intermittent |
Behavioral: Alteration of classical conditioning Kidney, Ureter, and Bladder: Other changes in urine composition Biochemical: Metabolism (intermediary): Porphyrin including bile pigments | VCVGK* -,461,1994 |
inhalation rat | lowest published toxic concentration: 77 mg/m3/106 day- intermittent |
Brain and Coverings: Other degenerative changes Liver: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase | VCVGK* -,461,1994 |
inhalation rat | lowest published toxic concentration: 15 mg/m3/167 day- intermittent |
Behavioral: Alteration of classical conditioning Kidney, Ureter, and Bladder: Other changes in urine composition Biochemical: Metabolism (intermediary): Porphyrin including bile pigments | VCVGK* -,461,1994 |
inhalation rabbit | lowest published toxic concentration: 15 mg/m3/167 day- intermittent |
Behavioral: Alteration of classical conditioning Kidney, Ureter, and Bladder: Other changes in urine composition Biochemical: Metabolism (intermediary): Porphyrin including bile pigments | VCVGK* -,461,1994 |
oral rat | lowest published toxic dose: 18,000 mg/kg/60 day- intermittent |
Behavioral: Somnolence (general depressed activity) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | VCVGK* -,461,1994 |
oral rat | lowest published toxic dose: 21 gm/kg/28 day- intermittent |
Behavioral: Change in motor activity (specific assay) Behavioral: Change in psychophysiological tests | TOXID9 72,76,2003 |
oral rat | lowest published toxic dose: 21 gm/kg/28 day- intermittent |
Behavioral: Food intake (animal) Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | TOXID9 72,76,2003 |
oral rat | lowest published toxic dose: 6.3 gm/kg/28 day- intermittent | Gastrointestinal: Changes in structure or function of salivary glands | TOXID9 72,76,2003 |
oral rabbit | lowest published toxic dose: 45.5 mg/kg/13 week- intermittent |
Behavioral: Somnolence (general depressed activity) Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Nutritional and Gross Metabolic: Weight loss or decreased weight gain | VCVGK* -,461,1994 |
oral rabbit | lowest published toxic dose: 4.55 mg/kg/13 week- intermittent | Behavioral: Alteration of classical conditioning | VCVGK* -,461,1994 |
REVIEWS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 10 ppm | DTLVS* TLV/BEI,2003 |
TOXICOLOGY REVIEW |
| TOLED5 144,383,2003 |
STANDARDS AND REGULATIONS: | ||
ORGANIZATION | STANDARD |
REFERENCE |
Occupational Exposure Limit - HUNGARY | time-weighted average 15 mg/m3, short term exposure limit 30 mg/m3, Skin, JAN1993 | |
Occupational Exposure Limit - RUSSIA | short term exposure limit 5 mg/m3, Skin, JAN1993 | |
Occupational Exposure Limit - THE NETHERLANDS | MAC-TGG 49 mg/m3, 2003 |
NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 80265; Number of Industries 48; Total Number of Facilities 4,433; Number of Occupations 61; Total Number of Employees Exposed 78,624; Total Number of Female Employees Exposed 31,148 |
STATUS IN FEDERAL AGENCIES: | |
ORGANIZATION |
REFERENCE |
EPA GENETOX PROGRAM 1988, Negative: E coli polA without S9; E coli polA with S9 | |
EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
Used as a hypnotic agent, in perfumes, organic synthesis, and in polymerization of olefins | |
EPA TSCA Section 8(d) unpublished health/safety studies | |
On EPA IRIS database | |
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001 |
REFERENCES: | |
CODEN |
REFERENCE |
AJOPAA | American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- |
DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
ESKHA5 | Eisei Shikenjo Hokoku. Bulletin of the Institute of Hygienic Sciences. (Kokuritsu Eisei Shikenjo Kagaku, 18-1 Bushitsu Johobu, Setagaya-ku, Tokyo 158, Japan) V.1- 1886- |
GTPZAB | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI |
HDTU** | "Pharmakologische Prufung von Analgetika, Dissertation," Herrlen, G., Pharmakologischen Institut der Universitat Tubingen, Fed. Rep. Ger., 1933 |
JIHTAB | Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. |
NTIS** | National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. |
TOLED5 | Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- |
TOXID9 | Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- |
UCDS** | Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) |
VCVGK* | "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. |