The Registry of Toxic Effects of Chemical Substances

Acetone

RTECS #: AL3150000

CAS #: 67-64-1

UPDATE: May 2005 MW: 58.09 MF: C3H6O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Aceton (German, Dutch, Polish)
  2. Chevron acetone
  3. Dimethylformaldehyde
  4. Dimethylketal
  5. Dimethyl ketone
  6. Ketone, dimethyl
  7. Ketone propane
  8. beta - Ketopropane
  1. Methyl ketone
  2. Pyroacetic acid
  3. Pyroacetic ether
  4. RCRA waste number U002
  5. Acetone (ACGIH:OSHA)
  6. Propanone
  7. 2 - Propanone


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		500 ppm N/R JIHTAB 25,282,1943
eye
human 		186,300 ppm mild CRTXB2 32,43,2002
eye
rabbit 		20 mg severe AJOPAA 29,1363,1946
eye
rabbit 		20 mg/24 hour moderate 85JCAE -,280,1986
eye
rabbit 		10 µL mild JTPAE7 29,187,2001
skin
rabbit 		395 mg open irritation test mild UCDS** 5/7/1970
skin
rabbit 		500 mg/24 hour mild 85JCAE -,280,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster fibroblast 40 gm/L FCTOD7 22,623,1984
sex chromosome loss and nondisjunction inhalation
mouse 		12 gm/L VCVGK* -,409,1994
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 47,600 ppm ANYAA9 407,186,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 31,500 µg/m3/24 hour (1-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) GTPZAB 26(6),24,1982
inhalation
mouse 		lowest published toxic concentration: 6,600 ppm (6-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		NTIS** #DE89-005671
inhalation
rat 		lowest published toxic concentration: 30 mg/m3 (1-13 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		VCVGK* -,409,1994
inhalation
rat 		lowest published toxic concentration: 11,000 ppm (6-19 day pregnant) Reproductive: Other developmental abnormalities NTIS** #DE89-005671
oral
rat 		lowest published toxic dose: 273 gm/kg (13 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) NTIS** PB91-185975


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 8,000 mg/m3 Eye: Conjunctiva irritation

Behavioral: Sleep 		VCVGK* -,408,1984
inhalation
guinea pig 		lowest published toxic concentration: 72,000 mg/m3/2 hour Behavioral: Alteration of classical conditioning VCVGK* -,408,1984
inhalation
human 		lowest published toxic concentration: 500 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes 		JIHTAB 25,282,1943
inhalation
human 		lowest published toxic concentration: 12,000 mg/m3/3 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVGK* -,408,1984
inhalation
human 		lowest published toxic concentration: 10 mg/m3/6 hour Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase VCVGK* -,408,1984
inhalation
man 		lowest published toxic concentration: 440 µg/m3/6 minute Brain and Coverings: Recordings from specific areas of CNS GISAAA 42(8),42,1977
inhalation
man 		lowest published toxic concentration: 10 mg/m3/6 hour Biochemical: Metabolism (intermediary): Other carbohydrates GISAAA 42(8),42,1977
inhalation
man 		lowest published toxic concentration: 12,000 ppm/4 hour Gastrointestinal: Nausea or vomiting

Behavioral: Muscle weakness 		AOHYA3 16,73,1973
inhalation
mouse 		lethal concentration (50 percent kill): 44 gm/m3/4 hour N/R CUTOEX 1,47,1993
inhalation
mouse 		lowest published toxic concentration: 30,000 mg/m3/2 hour Behavioral: Alteration of classical conditioning VCVGK* -,408,1984
inhalation
mouse 		lowest published lethal concentration: 150,000 mg/m3 N/R VCVGK* -,408,1984
inhalation
mouse 		lowest published toxic concentration: 10,000 ppm/6 minute Lung, Thorax, or Respiration: Respiratory depression TOLED5 9,137,1981
inhalation
rat 		lethal concentration (50 percent kill): 50,100 mg/m3/8 hour N/R AIHAAP 20,364,1959
inhalation
rat 		lowest published toxic concentration: 30,000 mg/m3/2 hour Behavioral: Alteration of classical conditioning VCVGK* -,408,1984
inhalation
rabbit 		lowest published toxic concentration: 1,250 mg/m3 Behavioral: Alteration of classical conditioning VCVGK* -,408,1984
intraperitoneal
dog 		lowest published lethal dose: 8 gm/kg Behavioral: Coma

Gastrointestinal: Alteration in gastric secretion 		AEXPBL 18,218,1884
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,297 mg/kg N/R SCCUR* -,1,1961
intraperitoneal
rat 		lowest published lethal dose: 500 mg/kg Behavioral: General anesthetic

Behavioral: Muscle weakness

Kidney, Ureter, and Bladder: Renal function tests depressed 		JPPMAB 11,150,1959
intravenous
mouse 		lowest published lethal dose: 4 gm/kg N/R FAONAU 48A,86,1970
intravenous
rat 		lethal dose (50 percent kill): 5,500 mg/kg N/R NPIRI* 1,1,1974
intravenous
rabbit 		lowest published lethal dose: 1,576 mg/kg Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Respiratory depression 		JPETAB 33,175,1928
oral
dog 		lowest published lethal dose: 8 gm/kg Behavioral: Ataxia

Behavioral: Coma

Musculoskeletal: Joints 		AEXPBL 18,218,1884
oral
dog 		lowest published lethal dose: 8,000 mg/kg N/R VCVGK* -,408,1984
oral
human 		lowest published lethal dose: 714 mg/kg N/R VCVGK* -,409,1984
oral
mammal (species unspecified) 		lowest published toxic dose: 3.49 gm/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Effect on specific coenzyme: NAD, NADP 		VCVGK* -,408,1984
oral
man 		lowest published toxic dose: 2,857 mg/kg Behavioral: Coma

Kidney, Ureter, and Bladder: Other changes 		34ZIAG -,64,1969
oral
man 		lowest published toxic dose: 2,857 mg/kg Behavioral: Coma

Biochemical: Metabolism (intermediary): Other 		DIAEAZ 15,810,1966
oral
mouse 		lethal dose (50 percent kill): 3 gm/kg N/R PCJOAU 14,162,1980
oral
rat 		lethal dose (50 percent kill): 5,800 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Tremor 		JTEHD6 15,609,1985
oral
rabbit 		lethal dose (50 percent kill): 5,340 mg/kg N/R FAONAU 48A,86,1970
subcutaneous
dog 		lowest published lethal dose: 5 gm/kg N/R AEXPBL 18,218,1884
subcutaneous
guinea pig 		lowest published lethal dose: 5 gm/kg N/R AGGHAR 5,1,1933
skin
guinea pig 		lethal dose (50 percent kill): >9,400 µL/kg N/R TXAPA9 7,559,1965
skin
rabbit 		lowest published lethal dose: 20 mL/kg N/R UCDS** 5/7/1970
unreported route
man 		lowest published lethal dose: 1,159 mg/kg N/R 85DCAI 2,73,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 100 mg/m3/6 hour/5 day- intermittent Cardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate increased without fall in BP

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		VCVGK* -,409,1994
inhalation
human 		lowest published toxic concentration: 440 mg/m3/3 year- intermittent Blood: Changes in erythrocyte (RBC) count

Blood: Granulocytopenia 		VCVGK* -,410,1994
inhalation
mouse 		lowest published toxic concentration: 11,000 ppm/12 day- intermittent Behavioral: General anesthetic NTIS** #DE89-005671
inhalation
rat 		lowest published toxic concentration: 19,000 ppm/3 hour/8 week- intermittent Brain and Coverings: Changes in brain weight TXAPA9 61,302,1981
inhalation
rat 		lowest published toxic concentration: 199 mg/m3/8 hour/45 day- intermittent Behavioral: Muscle contraction or spasticity GISAAA 25(5),3,1960
inhalation
rat 		lowest published toxic concentration: 30 mg/m3/13 day- intermittent Biochemical: Metabolism (intermediary): Lipids including transport VCVGK* -,409,1994
inhalation
rat 		lowest published toxic concentration: 2,000 mg/m3/4 hour/45 day- intermittent Endocrine: Change in gonadotropins

Endocrine: Evidence of thyroid hyperfunction

Biochemical: Metabolism (intermediary): Effect on Na-K pump 		VCVGK* -,409,1994
inhalation
rat 		lowest published toxic concentration: 199 mg/m3/8 hour/45 day- intermittent Behavioral: Alteration of classical conditioning VCVGK* -,409,1994
inhalation
rat 		lowest published toxic concentration: 206 mg/m3/21 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Reproductive: Other effects on female 		GISAAA 4,12,1994
inhalation
rat 		lowest published toxic concentration: 11,000 ppm/9 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #DE89-005671
oral
mouse 		lowest published toxic dose: 546 gm/kg/13 week- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight 		NTPTR* NIH-91-3122
oral
mouse 		lowest published toxic dose: 2 mg/kg/5 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		LIFSAK 69,923,2001
oral
rat 		lowest published toxic dose: 273 gm/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia 		NTPTR* NIH-91-3122
oral
rat 		lowest published toxic dose: 5 mg/kg/5 day- continuous Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		LIFSAK 69,923,2001
oral
rat 		lowest published toxic dose: 7 gm/kg/7 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) BCPCA6 67,875,2004
oral
rat 		lowest published toxic dose: 15 mL/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) 		TOLED5 144,55,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 500 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 500 ppm;short term exposure limit 750 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 750 ppm DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
TOLED5 127,111,2002
TOXICOLOGY REVIEW
CRTXB2 32,43,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,289,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1000 ppm (2400 mg/m3) DTLVS* 3,3,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1000 ppm (2400 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1000 ppm (2400 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1000 ppm (2400 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1000 ppm (2400 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 500 ppm (1185 mg/m3), short term exposure limit 1000 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 750 ppm (1780 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 750 ppm (1780 mg/m3), short term exposure limit 1000 ppm, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 250 ppm (600 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 500 ppm (1200 mg/m3), short term exposure limit 625 ppm (1500 mg/m3), JAN1993
Occupational Exposure Limit - FRANCE VME 750 ppm (1800 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 500 ppm (1200 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 600 mg/m3, short term exposure limit 1200 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1780 mg/m3, 2003
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 200 ppm (470 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 125 ppm (295 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1000 ppm (2400 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 600 mg/m3, MAC(short term exposure limit) 1800 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 200 ppm, short term exposure limit 200 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 250 ppm (600 mg/m3), KTV 500 ppm (1200 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 500 ppm (1200 mg/m3), short term exposure limit 1000 ppm (2400 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 1000 ppm (2400 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 750 ppm (1810 mg/m3), short term exposure limit 1500 ppm (3620 mg/m3),
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 750 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 750 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ACETONE-air 10 hour time-weighted average 250 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 02820;
Number of Industries 350;
Total Number of Facilities 99,713;
Number of Occupations 188;
Total Number of Employees Exposed 1,287,794
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 02820;
Number of Industries 358;
Total Number of Facilities 97,342;
Number of Occupations 215;
Total Number of Employees Exposed 1,740,164;
Total Number of Female Employees Exposed 540,313


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/100095/AS)
EPA GENETOX PROGRAM 1988, Negative: SHE-clonal assay; Cell transform.-mouse embryo
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solubilizer
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ketones I, 1300
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NTP Toxicity studies, RPT# TOX-03, October 2000
OSHA ANALYTICAL METHOD #ID-69


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
AOHYA3 Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
CUTOEX Current Toxicology. (Nova Science Publishers, Inc., 6080 Jericho Turnpike, Suite 207, Commack, NY 11725) V.1 1993-
DIAEAZ Diabetes. (American Diabetes Assoc., 2 Park Ave., New York, NY 10016) V.1- 1952-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a solubilizer

Top 50 chemical production: 2.39 billions lbs in 1992, 2.35 billions in 1991

NIOSH PROFILE (CORROSION INHIBITORS, MANUFACTURE and USE), FIRL,

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (SPRAY PAINTING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

 Click Here for Additional Information about RTECS