The Registry of Toxic Effects of Chemical Substances

Acetimidic acid, thio - N - ( (methylcarbamoyl) oxy) - , methyl ester

RTECS #: AK2975000

CAS #: 16752-77-5

UPDATE: November 2004 MW: 162.23 MF: C5H10N2O2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1N - X1179 - 412
  2. 2 - Methylthio - acetaldehyd - O - (methylcarbamoyl) - oxim (German)
  3. 2 - Methylthio - propionaldehyd - O - (methylcarbamoyl) - oxim (German)
  4. 3 - Thiabutan - 2 - one, O - (methylcarbamoyl) oxime
  5. Acetimidic acid, N - ( (methylcarbamoyl) oxy) thio - , methyl ester (8CI)
  6. Acetimidothioic acid, methyl - , N - (methylcarbamoyl) ester
  7. DPX - X1179 - 412
  8. Du Pont insecticide 1179
  9. Dupont 1179
  10. ENT 27,341
  11. Ethanimidothioic acid, N - ( ( (methylamino) carbonyl) oxy) - , methyl ester (9CI)
  12. IN 1179
  13. Insecticide 1,179
  14. Lannate
  15. Lannate 10L candidate
  16. Lannate L
  17. Lannate LV
  1. Mesomile
  2. Methomex
  3. Methomyl
  4. Methomyl (ACGIH)
  5. Methyl N - ( ( (methylamino) carbonyl) oxy) ethanimidothioate
  6. Methyl O - (methylcarbamoyl) thiolacethohydroxamate
  7. Methyl - N - ( (methylcarbamoyl) oxy) thioacetimidate
  8. Metomil (Italian)
  9. N - ( ( (Methylamino) carbonyl) oxy) ethanimidothioic acid methyl ester
  10. N - ( (Methylcarbamoyl) oxy) thioacetimidic acid methyl ester
  11. NU - Bait II
  12. Nudrin
  13. RCRA waste number P066
  14. S - Methyl N - (methylcarbamoyloxy) thioacetimidate
  15. S - Methyl N - (methylcarbamoyloxy) thioacetimidate
  16. SD 14999
  17. WL 18236


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 180 µmol/L EMMUEG 23,306,1994
cytogenetic analysis oral
mouse 		20 mg/kg ENVRAL 42,362,1987
DNA damage human lymphocyte 500 µmol/L EMMUEG 23,306,1994
DNA damage human lymphocyte 1 mmol/L EMMUEG 23,306,1994
DNA damage intraperitoneal
mouse 		5 mg/kg EMMUEG 24,235,1994
DNA damage intraperitoneal
mouse 		10 mg/kg EMMUEG 24,235,1994
mutation in microorganisms Saccharomyes cerevisiae 50 ppm (-enzymatic activation step) RSTUDV 6,161,1976
micronucleus test human lymphocyte 10 µmol/L EMMUEG 23,306,1994
sperm morphology oral
mouse 		20 mg/kg ENVRAL 42,362,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
duck 		lethal concentration (50 percent kill): 1,890 ppm N/R TXAPA9 40,1,1977
inhalation
quail 		lethal concentration (50 percent kill): 3,680 ppm N/R TXAPA9 40,1,1977
inhalation
rat 		lethal concentration (50 percent kill): 77 ppm/4 hour Eye: Lacrimation

Behavioral: Tremor

Lung, Thorax, or Respiration: Dyspnea 		TXAPA9 40,1,1977
inhalation
rat 		lethal concentration (50 percent kill): 450 mg/m3 N/R HBPTO* 2,1094,2001
intraperitoneal
mouse 		lowest published toxic dose: 5.2 mg/kg Behavioral: Convulsions or effect on seizure threshold TOSCF2 72,289,2003
intraperitoneal
mouse 		lowest published lethal dose: 6.4 mg/kg Behavioral: Convulsions or effect on seizure threshold TOSCF2 72,289,2003
intraperitoneal
rat 		lethal dose (50 percent kill): 6,290 µg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Straub Tail 		ETOPFR 7,119,1999
oral
wild bird 		lethal dose (50 percent kill): 10 mg/kg N/R TXAPA9 21,315,1972
oral
chicken 		lethal dose (50 percent kill): 28 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		TXAPA9 40,1,1977
oral
duck 		lethal dose (50 percent kill): 15 mg/kg N/R SHELL*
oral
dog 		lethal dose (50 percent kill): 20 mg/kg N/R 85INA8 6,906,1991
oral
guinea pig 		lowest published lethal dose: 15 mg/kg N/R TXAPA9 40,1,1977
oral
human 		lethal dose : 12 mg/kg Brain and Coverings: Other degenerative changes

Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		HBPTO* 2,1097,2001
oral
monkey 		lowest published lethal dose: 40 mg/kg N/R TXAPA9 40,1,1977
oral
mouse 		lethal dose (50 percent kill): 10 mg/kg N/R JAFCAU 26,550,1978
oral
pigeon 		lethal dose (50 percent kill): 10 mg/kg N/R ASTTA8 (680),157,1979
oral
quail 		lethal dose (50 percent kill): 23,700 µg/kg N/R ASTTA8 (680),157,1979
oral
rat 		lethal dose (50 percent kill): 12 mg/kg N/R HBPTO* 2,1094,2001
subcutaneous
rat 		lethal dose (50 percent kill): 9 mg/kg N/R TXAPA9 25,569,1973
skin
rat 		lethal dose (50 percent kill): 1,000 mg/kg N/R HBPTO* 2,1094,2001
skin
rabbit 		lethal dose (50 percent kill): 556 mg/kg N/R HBPTO* 2,1094,2001
unreported route
rat 		lethal dose (50 percent kill): 17 mg/kg N/R VCVGK* -,512,1994


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 18,200 mg/kg/2 year- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in bone marrow not included in above

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 40,1,1977
oral
rat 		lowest published toxic dose: 14,700 µg/kg/5 day- intermittent Peripheral Nerve and Sensation: Structural change in nerve or sheath

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		WDZAEK 6,37,1992
oral
rat 		lowest published toxic dose: 102 mg/kg/60 day- intermittent Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		JDGRAX 22,259,1998
oral
rat 		lowest published toxic dose: 15,960 mg/kg/95 week- continuous Blood: Changes in bone marrow not included in above

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight 		TXAPA9 40,1,1977
oral
rat 		lowest published toxic dose: 264 mg/kg/33 day- intermittent Brain and Coverings: Other degenerative changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		CMSHAF 23,375,1991
oral
rat 		lowest published toxic dose: 9 mg/kg/90 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JDGRAX 18,145,1989
skin
rabbit 		lowest published toxic dose: 3 gm/kg/3 week- intermittent Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 40,1,1977


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2.5 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 557,109,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,131,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 2.5 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 2.5 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 2.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 2.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 2.5 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 2.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2.5 mg/m3, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2.5 mg/m3, Skin, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHOMYL-air 10 hour time-weighted average 2.5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: B0027;
Number of Industries 1;
Total Number of Facilities 15;
Number of Occupations 1;
Total Number of Employees Exposed 2,367;
Total Number of Female Employees Exposed 1,288


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
Used as insecticide in many vegetables, field crops, certain fruit crops and ornamentals
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RSTUDV Rivista di Scienza e Technologia degli Alimenti e di Nutrizione Umana. Review of Science and Technology of Food and Human Nutrition. (Bologna, Italy) V.5-6, 1975-76. Discontinued.
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

Used as insecticide in many vegetables, field crops, certain fruit crops and ornamentals

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

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