The Registry of Toxic Effects of Chemical Substances

Acetic acid, trichloro - , sodium salt

RTECS #: AJ9100000

CAS #: 650-51-1

UPDATE: August 2003 MW: 185.36 MF: C2Cl3O2•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Dow sodium TCA inhibited
  2. Green cross couch grass killer
  3. Natriumtrichlooracetaat (Dutch)
  4. Natriumtrichloracetat (German)
  5. Sodio (tricloroacetato di) (Italian)
  6. Sodium TCA
  7. Sodium TCA inhibited
  8. Sodium (trichloracetate de) (French)
  9. Sodium trichloroacetate
  10. STCA
  1. TCA sodium
  2. Trichloressigsaures natrium (German)
  3. Trichloroacetic acid sodium salt
  4. Trichloroctan sodny (Czech)
  5. Varitox
  6. Weedmaster grass killer
  7. ACP grass killer
  8. Allied Arcadian Sodium TCA
  9. Antiperz
  10. Antyperz


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis human lymphocyte 100 mg/L TGANAK 18,318,1984
mutation in mammalian somatic cells mouse lymphocyte 2,400 mg/L MUREAV 413,265,1998


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 158 gm/kg/1 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		TXAPA9 144,235,1997


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >365 gm/m3/4 hour N/R 85JFAN A377,1983
oral
cat 		lethal dose (50 percent kill): 4 gm/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness 		GISAAA 32(1),48,1967
oral
chicken 		lethal dose (50 percent kill): 4,280 mg/kg N/R DOEAAH 35,25,1979
oral
guinea pig 		lethal dose (50 percent kill): 6 gm/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness 		GISAAA 32(1),48,1967
oral
mouse 		lethal dose (50 percent kill): 3,600 mg/kg N/R PCOC** -,1061,1966
oral
rat 		lethal dose (50 percent kill): 3,320 mg/kg N/R KSKZAN 18(3),46,1980
oral
rabbit 		lethal dose (50 percent kill): 6 gm/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness 		GISAAA 32(1),48,1967
skin
rat 		lethal dose (50 percent kill): >2 gm/kg N/R 85JFAN A377,1983
skin
rabbit 		lethal dose : >10,100 mg/kg Behavioral: Food intake (animal) NTIS** OTS0545852
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 3,300 mg/kg N/R 30ZDA9 -,121,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,140 mg/kg/15 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition TXCYAC 146,123,2000


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,338,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X8546;
Number of Industries 1;
Total Number of Facilities 16;
Number of Occupations 1;
Total Number of Employees Exposed 1,462;
Total Number of Female Employees Exposed 996


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an herbicide
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
KSKZAN Khimiya v Sel'skom Khozyaistve. Chemistry in Agriculture. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1963-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as an herbicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

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