The Registry of Toxic Effects of Chemical Substances

Acetic acid, trichloro -

RTECS #: AJ7875000

CAS #: 76-03-9

UPDATE: May 2005 MW: 163.38 MF: C2HCl3O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Aceto - caustin
  2. Acide trichloracetique (French)
  3. Acido tricloroacetico (Italian)
  4. Amchem grass killer
  5. Konesta
  6. Kyselina trichloroctova (Czech)
  7. NA TA
  8. Sodium TCA solution
  1. Trichloorazijnzuur (Dutch)
  2. Trichloressigsaeure (German)
  3. Trichloroacetate
  4. Trichloroacetic acid
  5. Trichloroacetic acid (ACGIH)
  6. Trichloroacetic acid (IUPAC)
  7. Trichloroethanoic acid
  8. Trichloromethanecarboxylic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		3,500 µg/5S severe XEURAQ MDDC-1715
skin
rabbit 		210 µg mild XEURAQ MDDC-1715


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis intraperitoneal
chicken 		200 mg/kg MUREAV 367,253,1996
cytogenetic analysis intraperitoneal
mouse 		125 mg/kg MUREAV 188,215,1987
cytogenetic analysis oral
mouse 		500 mg/kg MUREAV 188,215,1987
DNA adduct intraperitoneal
mouse 		2,000 nmol/L/1 week- intermittent CALEDQ 185,13,2002
DNA damage oral
mouse 		500 mg/kg EVHPAZ 108,241,2000
mutation in microorganisms Salmonella typhimurium 250 µg/plate (+enzymatic activation step) CNJGA8 22,35,1980
micronucleus test intraperitoneal
mouse 		300 mg/kg/24 hour MUREAV 188,215,1987
other mutation test systems oral
mouse 		250 mg/kg MUREAV 343,157,1995
sperm morphology intraperitoneal
mouse 		125 mg/kg/5 day MUREAV 188,215,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 125 mg/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) MUREAV 188,215,1987
oral
rat 		lowest published toxic dose: 3,300 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 40,445,1989
oral
rat 		lowest published toxic dose: 8 gm/kg (6-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		TJADAB 40,445,1989
oral
rat 		lowest published toxic dose: 6,402 mg/kg (1-22 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		JACCDI 32,540,1998
oral
rat 		lowest published toxic dose: 3,025 mg/kg (1-11 day pregnant) Reproductive: Specific developmental abnormalities: Homeostasis BDERE* 67,488,2003


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 427 gm/kg/61 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors 		TXAPA9 90,183,1987
oral
mouse 		lowest published toxic dose: 210 gm/kg/12 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Tumorigenic: Facilitates action of known carcinogens 		CALEDQ 158,185,2000
oral
mouse 		lowest published toxic dose: 145.6 gm/kg/52 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains 		TXAPA9 182,55,2002


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published lethal dose: 500 mg/kg N/R CBCCT* 6,214,1954
subcutaneous
mouse 		lethal dose (50 percent kill): 270 mg/kg N/R NIIRDN 6,879,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 1,420 mg/kg/10 week- continuous Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Effect on specific coenzyme: CoA 		TXCYAC 110,103,1996
oral
mouse 		lowest published toxic dose: 5.04 gm/kg/12 week- continuous Liver: Changes in liver weight

Endocrine: Hypoglycemia 		JAPTO* 21,81,2001
oral
mouse 		lowest published toxic dose: 145,600 mg/kg/52 week- continuous Liver: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains 		EVHPAZ 108,343,2000
oral
mouse 		lowest published toxic dose: 427 gm/kg/61 week- continuous Liver: Tumors

Tumorigenic: Tumor types after systemic administration not seen spontaneously 		EVHPAZ 108,241,2000
oral
mouse 		lowest published toxic dose: 72.8 gm/kg/52 week- continuous Liver: Tumors

Tumorigenic: Tumor types after systemic administration not seen spontaneously 		EVHPAZ 108,241,2000
oral
mouse 		lowest published toxic dose: 42 gm/kg/60 week- continuous Liver: Tumors

Tumorigenic: Tumor types after systemic administration not seen spontaneously 		EVHPAZ 108,241,2000
oral
rat 		lowest published toxic dose: 32 gm/kg/90 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		TXCYAC 64,71,1990
oral
rat 		lowest published toxic dose: 398 mg/kg/10 week- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		TOLED5 80,97,1995


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 63,291,1995
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 63,291,1995
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 63,291,1995
TOXICOLOGY REVIEW
MUREAV 539,77,2003
TOXICOLOGY REVIEW
TOLED5 127,135,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,338,1998
Occupational Exposure Limit - AUSTRIA MAK 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (6.7 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.75 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (7 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 1 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRICHLOROACETIC ACID-air 10 hour time-weighted average 1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81560;
Number of Industries 8;
Total Number of Facilities 1,353;
Number of Occupations 13;
Total Number of Employees Exposed 13,946
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81560;
Number of Industries 9;
Total Number of Facilities 1,562;
Number of Occupations 21;
Total Number of Employees Exposed 35,124;
Total Number of Female Employees Exposed 16,821


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as medication, in organic syntheses, and as a reagent for albumin detection
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
BDERE* Birth Defects Research Part A, Clinical and molecular teratology (Hoboken, N.J. : John Wiley & Sons) V.67- 2003-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1959-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JACCDI Journal of the American College of Cardiology. (Elsevier Science, P.O. Box 945 New York, NY 10159) V.1- 1983-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
XEURAQ U.S. Atomic Energy Commission, University of Rochester, Research and Development Reports. (Rochester, NY)

Used as medication, in organic syntheses, and as a reagent for albumin detection

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Primary Irritant

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