The Registry of Toxic Effects of Chemical Substances

Acetic acid, sodium salt

RTECS #: AJ4300010

CAS #: 127-09-3

UPDATE: October 1997 MW: 82.04 MF: C2H3O2•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Natriumacetat (German)
  2. Sodium acetate
  1. Anhydrous sodium acetate
  2. Octan sodny (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		10 mg mild BIOFX* 19-3/1971
skin
rabbit 		500 mg/24 hour mild BIOFX* 19-3/1971


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >30 gm/m3/1 hour N/R BIOFX* 19-3/1971
intravenous
mouse 		lowest published lethal dose: 1,195 mg/kg N/R JLCMAK 29,809,1944
intravenous
rabbit 		lowest published lethal dose: 1,300 mg/kg Behavioral: Toxic psychosis

Behavioral: Fluid intake

Kidney, Ureter, and Bladder: Urine volume increased 		AEXPBL 21,119,1886
oral
mouse 		lethal dose (50 percent kill): 6,891 mg/kg N/R JIHTAB 23,78,1941
oral
rat 		lethal dose (50 percent kill): 3,530 mg/kg N/R FAONAU 40,126,1967
subcutaneous
mouse 		lethal dose (50 percent kill): 3,200 mg/kg N/R TOXIA6 24,553,1986
skin
rabbit 		lethal dose (50 percent kill): >10 gm/kg N/R BIOFX* 19-3/1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 68770;
Number of Industries 122;
Total Number of Facilities 16,581;
Number of Occupations 65;
Total Number of Employees Exposed 94,994
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 68770;
Number of Industries 192;
Total Number of Facilities 32,101;
Number of Occupations 151;
Total Number of Employees Exposed 563,021;
Total Number of Female Employees Exposed 247,479


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-human lymphocytes; In vitro SCE-human
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a buffer in many chemical intermediates
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC.
BIOFX* BIOFAX Industrial Bio-Test Laboratories, Inc., Data Sheets. (1810 Frontage Rd., Northbrook, IL 60062)
FAONAU FAO Nutrition Meetings Report Series. (Rome, Italy) No.?-57, 1948-77. Discontinued.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915-
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-

Used as a buffer in many chemical intermediates

NIOSH PROFILE (ACETATES), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Primary Irritant

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