The Registry of Toxic Effects of Chemical Substances

Acetic acid, nitrilotri -

RTECS #: AJ0175000

CAS #: 139-13-9

UPDATE: May 2005 MW: 191.16 MF: C6H9NO6


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. N,N - Bis (carboxymethyl) glycine
  2. CHEL 300
  3. Complexon I
  4. Glycine, N,N - bis (carboxymethyl) - (9CI)
  5. Hampshire NTA acid
  6. Komplexon I
  7. Kyselina nitrilotrioctova (Czech)
  8. NCI - C02766
  9. Nitrilotriacetic acid
  1. Nitrilotris (methylenecarboxylic acid)
  2. Titriplex I
  3. Versene NTA acid
  4. Aminotriacetic acid
  5. NTA
  6. Triglycine
  7. Triglycollamic acid
  8. Trilon A
  9. alpha,alpha',alpha'' - Trimethylaminetricarboxylic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage human other cell types 2 mmol/L/20 hour TXCYAC 179,115,2002
DNA damage rat other cell types 2 mmol/L/20 hour TXCYAC 179,115,2002
morphological transform hamster embryo 2 gm/L MUREAV 356,85,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 832 gm/kg/66 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		NCITR* NCI-TR-6,1977
oral
rat 		lowest published toxic dose: 430 gm/kg/75 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		NCITR* NCI-TR-6,1977


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 325 mg/kg N/R CRTXB2 20,83,1989
oral
mouse 		lethal dose (50 percent kill): 3,160 mg/kg N/R NCILB* NCI-E-C-72-3252,1973
oral
rat 		lethal dose (50 percent kill): 1,100 mg/kg N/R ACIEAY 14,94,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 41,292 mg/kg/7 week- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) FCTOD7 20,925,1982
oral
rat 		lowest published toxic dose: 29,439 µg/kg/4 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Changes in: Ca 		FCTXAV 17,137,1979


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 48,181,1990
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 73,385,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 48,181,1990
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,385,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 73,385,1999
TOXICOLOGY REVIEW
MUREAV 567,227,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80058;
Number of Industries 31;
Total Number of Facilities 1,115;
Number of Occupations 32;
Total Number of Employees Exposed 13,454
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80058;
Number of Industries 24;
Total Number of Facilities 1,082;
Number of Occupations 23;
Total Number of Employees Exposed 25,216;
Total Number of Female Employees Exposed 7,169


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a phosphate replacement in laundry detergents
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,rat NCITR* NCI-TR-6,1977
NTP 10th Report on Carcinogens,2002:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
ACIEAY Angewandte Chemie, International Edition in English. (VCH Pub., Inc., 303 NW 12th Ave., Deerfield Beach, FL 33441) V.1- 1962-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD)
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a phosphate replacement in laundry detergents

RTECS Compound Description:
   Tumorigen
   Mutagen

ALT CAS #: 26627-44-1
ALT CAS #: 26627-45-2
ALT CAS #: 80751-51-5
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