The Registry of Toxic Effects of Chemical Substances
Acetic acid, methyl ester |
UPDATE: November 2004 | MW: 74.09 | MF: C3H6O2 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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eye | rabbit
100 mg/24 hour
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moderate
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85JCAE -,353,1986
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skin | rabbit
500 mg/24 hour
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mild
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FCTXAV 17,859,1979
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skin | rabbit
20 mg/24 hour
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moderate
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85JCAE -,353,1986
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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sex chromosome loss and nondisjunction
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Saccharomyes cerevisiae
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33,800 ppm
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MUREAV 149,339,1985
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intraduodenal | rabbit
lethal dose (50 percent kill): 3,700 mg/kg
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N/R
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FCTXAV 17,859,1979
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inhalation | cat
lowest published lethal concentration: 67 gm/m3/1 hour
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Eye: Lacrimation | Behavioral: Convulsions or effect on seizure threshold Gastrointestinal: Changes in structure or function of salivary glands
AGGHAR 5,1,1933
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inhalation | human
lowest published toxic concentration: 15,000 mg/m3
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Eye: Lacrimation | Lung, Thorax, or Respiration: Cough Lung, Thorax, or Respiration: Other changes
AGGHAR 5,1,1933
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inhalation | mouse
lowest published lethal concentration: 34 gm/m3/4 hour
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Behavioral: General anesthetic
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AGGHAR 5,1,1933
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inhalation | rat
lowest published lethal concentration: 32,000 ppm/4 hour
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N/R
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AIHAAP 23,95,1962
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oral | rat
lethal dose (50 percent kill): >5 gm/kg
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N/R
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FCTXAV 17,859,1979
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oral | rabbit
lethal dose (50 percent kill): 3,705 mg/kg
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N/R
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IMSUAI 41,31,1972
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subcutaneous | cat
lowest published lethal dose: 3 gm/kg
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Behavioral: Somnolence (general depressed activity) | Behavioral: Ataxia Lung, Thorax, or Respiration: Respiratory depression
AGGHAR 5,1,1933
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subcutaneous | guinea pig
lowest published lethal dose: 3 gm/kg
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N/R
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AGGHAR 5,1,1933
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subcutaneous | rat
lowest published lethal dose: 8 gm/kg
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N/R
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BSIBAC 18,45,1943
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skin | guinea pig
lethal dose (50 percent kill): >20 mL/kg
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N/R
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NTIS** OTS0556681
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skin | rabbit
lethal dose (50 percent kill): >5 gm/kg
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N/R
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FCTXAV 17,859,1979
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unreported route | mammal (species unspecified)
lethal dose (50 percent kill): 214 mg/kg
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N/R
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GISAAA 33(8),107,1968
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | dog
lowest published toxic concentration: 28 gm/m3/40 minute/4 week- intermittent
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Behavioral: Ataxia | Lung, Thorax, or Respiration: Respiratory stimulation Nutritional and Gross Metabolic: Body temperature decrease
NTIS** OTS0572401
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 200 ppm
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DTLVS* TLV/BEI,2002
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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time-weighted average 200 ppm;short term exposure limit 250 ppm
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DTLVS* TLV/BEI,2003
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
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short term exposure limit 250 ppm
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DTLVS* TLV/BEI,2002
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TOXICOLOGY REVIEW
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AMIHAB 21,28,1960
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air
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time-weighted average 200 ppm (610 mg/m3)
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DTLVS* 3,153,1971
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
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8 hour time-weighted average 200 ppm (610 mg/m3)
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CFRGBR 29,1910.1000,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
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8 hour time-weighted average 200 ppm (610 mg/m3)
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CFRGBR 29,1926.55,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
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8 hour time-weighted average 200 ppm (610 mg/m3)
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CFRGBR 29,1915.1000,1993
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)
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8 hour time-weighted average 200 ppm (610 mg/m3)
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CFRGBR 41,50-204.50,1994
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Occupational Exposure Limit - AUSTRALIA
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time-weighted average 200 ppm (610 mg/m3), short term exposure limit 250 ppm, JAN1993
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Occupational Exposure Limit - BELGIUM
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time-weighted average 200 ppm (610 mg/m3), short term exposure limit 250 ppm (760 mg/m3), JAN1993
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Occupational Exposure Limit - DENMARK
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time-weighted average 150 ppm (455 mg/m3), JAN1999
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Occupational Exposure Limit - AUSTRIA
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MAK 200 ppm (610 mg/m3), JAN1999
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Occupational Exposure Limit - FINLAND
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time-weighted average 200 ppm (610 mg/m3), short term exposure limit 250 ppm (765 mg/m3), JAN1993
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Occupational Exposure Limit - FRANCE
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VME 200 ppm (610 mg/m3), VLE 250 ppm (760 mg/m3), JAN1999
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Occupational Exposure Limit - GERMANY
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MAK 200 ppm (610 mg/m3), JAN1999
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Occupational Exposure Limit - HUNGARY
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time-weighted average 200 mg/m3, short term exposure limit 500 mg/m3, Skin, JAN1993
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Occupational Exposure Limit - THE NETHERLANDS
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MAC-TGG 610 mg/m3, 2003
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Occupational Exposure Limit - NORWAY
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time-weighted average 100 ppm (305 mg/m3), JAN1999
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Occupational Exposure Limit - THE PHILIPPINES
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time-weighted average 200 ppm (610 mg/m3), JAN1993
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Occupational Exposure Limit - POLAND
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MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 750 mg/m3, JAN1999
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Occupational Exposure Limit - RUSSIA
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time-weighted average 200 ppm, short term exposure limit 100 mg/m3, JAN1993
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Occupational Exposure Limit - SWEDEN
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time-weighted average 150 ppm (450 mg/m3), short term exposure limit 300 ppm (900 mg/m3), JAN1999
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Occupational Exposure Limit - SWITZERLAND
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MAK- week 200 ppm (610 mg/m3), KZG- week 400 ppm (1220 mg/m3), JAN1999
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Occupational Exposure Limit - TURKEY
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time-weighted average 200 ppm (610 mg/m3), JAN1993
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Occupational Exposure Limit - UNITED KINGDOM
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time-weighted average 200 ppm (616 mg/m3), short term exposure limit 250 ppm (770 mg/m3), SEP2000
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Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | short term exposure limit 250 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM
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American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
short term exposure limit 250 ppm |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL ACETATE-air
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10 hour time-weighted average 200 ppm; | short term exposure limit 250 ppm
NIOSH* DHHS #92-100,1992
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National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 46410; | Number of Industries 26; Total Number of Facilities 1,604; Number of Occupations 22; Total Number of Employees Exposed 5,611
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 46410; |
Number of Industries 15; Total Number of Facilities 387; Number of Occupations 31; Total Number of Employees Exposed 20,455; Total Number of Female Employees Exposed 6,018 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA Section 8(d) unpublished health/safety studies
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On EPA IRIS database
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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NIOSH Analytical Method, 1994: Methyl acetate, 1458
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REFERENCES:
CODEN
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REFERENCE
85JCAE
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"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986
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AGGHAR
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Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For
publisher information, see IAEHDW.
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AIHAAP
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American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH
44311) V.19- 1958-
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AMIHAB
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AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher
information, see AEHLAU.
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BSIBAC
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Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de
Gasperi, 55, 80133 Naples, Italy) V.2- 1927-
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CFRGBR
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Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402)
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DTLVS*
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The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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FCTXAV
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Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see
FCTOD7.
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GISAAA
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Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1936-
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IMSUAI
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Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher
information, see IOHSA5.
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MUREAV
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Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
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NIOSH*
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National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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