The Registry of Toxic Effects of Chemical Substances
Acetic acid, mercury (2+) salt |
| UPDATE: May 2004 | MW: 318.69 | MF: C4H6O4•Hg |
SYNONYMS: | |
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SKIN AND EYE IRRITATION DATA AND REFERENCES: | |||
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ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
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N/R | N/R | N/R | N/R |
MUTATION DATA AND REFERENCES: | |||
| SYSTEM TEST |
ROUTE/ ORGANISM/ TISSUE | DOSE | REFERENCE |
| mutation in mammalian somatic cells | hamster ovary | 100 nmol/L | EMMUEG 27,30,1996 |
| other mutation test systems | mouse other cell types | 50 mg/L | MUREAV 17,93,1973 |
REPRODUCTIVE EFFECTS DATA AND REFERENCES: | |||
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ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
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intraperitoneal hamster | lowest published toxic dose: 2 mg/kg (8 day pregnant) |
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Other developmental abnormalities | ENVRAL 8,207,1974 |
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intravenous hamster | lowest published toxic dose: 2 mg/kg (8 day pregnant) |
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Specific developmental abnormalities: Homeostasis | LSBGAY 10,1341,1971 |
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intravenous hamster | lowest published toxic dose: 4 mg/kg (8 day pregnant) |
Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Musculoskeletal system | ENVRAL 6,95,1973 |
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intravenous hamster | lowest published toxic dose: 4 mg/kg (8 day pregnant) | Reproductive: Other developmental abnormalities | ENVRAL 8,207,1974 |
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intravenous rat | lowest published toxic dose: 3 mg/kg (10 day pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | ATSUDG 7,382,1984 |
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oral hamster | lowest published toxic dose: 8 mg/kg (8 day pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | ENVRAL 8,207,1974 |
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oral hamster | lowest published toxic dose: 25 mg/kg (8 day pregnant) | Reproductive: Other developmental abnormalities | ENVRAL 8,207,1974 |
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oral hamster | lowest published toxic dose: 35 mg/kg (8 day pregnant) |
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | ENVRAL 8,207,1974 |
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oral hamster | lowest published toxic dose: 50 mg/kg (8 day pregnant) | Reproductive: Specific developmental abnormalities: Homeostasis | ENVRAL 8,207,1974 |
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subcutaneous hamster | lowest published toxic dose: 8 mg/kg (8 day pregnant) |
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Specific developmental abnormalities: Body wall | ENVRAL 8,207,1974 |
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subcutaneous hamster | lowest published toxic dose: 8 mg/kg (8 day pregnant) | Reproductive: Specific developmental abnormalities: Homeostasis | ENVRAL 8,207,1974 |
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subcutaneous hamster | lowest published toxic dose: 4 mg/kg (8 day pregnant) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | ENVRAL 8,207,1974 |
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subcutaneous hamster | lowest published toxic dose: 15 mg/kg (9 day pregnant) |
Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system | BECTA6 25,726,1980 |
TUMORIGENIC DATA AND REFERENCES: | |||
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ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
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N/R | N/R | N/R | N/R |
ACUTE TOXICITY DATA AND REFERENCES: | |||
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ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
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intraperitoneal mouse | lethal dose (50 percent kill): 6,500 µg/kg | N/R | GTPZAB 25(7),27,1981 |
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intravenous mouse | lethal dose (50 percent kill): 4,390 µg/kg |
Behavioral: Altered sleep time (including change in righting reflex) Behavioral: Ataxia Lung, Thorax, or Respiration: Other changes | NYKZAU 57,219,1961 |
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oral mouse | lethal dose (50 percent kill): 23,900 µg/kg | N/R | GISAAA 46(8),12,1981 |
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oral rat | lethal dose (50 percent kill): 40,900 µg/kg | N/R | GISAAA 46(8),12,1981 |
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subcutaneous mouse | lowest published lethal dose: 20 mg/kg | N/R | MOLAAF 73,751,1939 |
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skin rat | lethal dose (50 percent kill): 570 mg/kg | N/R | GTPZAB 25(7),27,1981 |
OTHER MULTIPLE DOSE DATA AND REFERENCES: | |||
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ROUTE/ ORGANISM | DOSE |
EFFECT | REFERENCE |
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oral rat | lowest published toxic dose: 4,246 mg/kg/1 year- continuous | Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) | AMIHBC 2,433,1950 |
REVIEWS: | ||
| ORGANIZATION | STANDARD |
REFERENCE |
| American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value | time-weighted average 0.01; short term exposure limit 0.03 mg/m3 (skin) | DTLVS* TLV/BEI,1999 |
| International Agency for Research on Cancer (IARC) Cancer Review | Human Inadequate Evidence | IMEMDT 58,239,1993 |
| International Agency for Research on Cancer (IARC) Cancer Review | Group 2B | IMEMDT 58,239,1993 |
| TOXICOLOGY REVIEW |
| AJOGAH 126,390,1976 |
STANDARDS AND REGULATIONS: | ||
| ORGANIZATION | STANDARD |
REFERENCE |
| Mine Safety and Health Administration (MSHA) STANDARD - air | time-weighted average 0.05 mg(Hg)/m3 | DTLWS* 3,22,1973 |
| Occupational Exposure Limit - AUSTRALIA | time-weighted average 0.05 mg(Hg)/m3, Skin, JAN1993 | |
| Occupational Exposure Limit - BELGIUM | time-weighted average 0.05 mg(Hg)/m3, Skin, JAN1993 | |
| Occupational Exposure Limit - DENMARK | time-weighted average 0.05 mg(Hg)/m3, JAN1999 | |
| Occupational Exposure Limit - FINLAND | time-weighted average 0.05 mg(Hg)/m3, JAN1993 | |
| Occupational Exposure Limit - FRANCE | VME 0.1 mg(Hg)/m3, Skin, JAN1999 | |
| Occupational Exposure Limit - GERMANY | MAK 0.01 ppm (0.1 mg(Hg)/m3), JAN1999 | |
| Occupational Exposure Limit - HUNGARY | time-weighted average 0.02 mg(Hg)/m3, short term exposure limit 0.04 mg(Hg)/m3, JAN1993 | |
| Occupational Exposure Limit - JAPAN | Occupational Exposure Limit 0.05 mg(Hg)/m3, JAN1999 | |
| Occupational Exposure Limit - NORWAY | time-weighted average 0.05 mg(Hg)/m3, JAN1999 | |
| Occupational Exposure Limit - THE PHILIPPINES | time-weighted average 0.05 mg(Hg)/m3, JAN1993 | |
| Occupational Exposure Limit - POLAND | MAC(time-weighted average) 0.05 mg(Hg)/m3, MAC(short term exposure limit) 0.15 mg(Hg)/m3, JAN1999 | |
| Occupational Exposure Limit - RUSSIA | time-weighted average 0.05 mg(Hg)/m3, short term exposure limit 0.01 mg(Hg)/m3, JAN1993 | |
| Occupational Exposure Limit - SWEDEN | NGV 0.05 mg(Hg)/m3, JAN1999 | |
| Occupational Exposure Limit - THAILAND | short term exposure limit 0.05 mg(Hg)/m3, JAN1993 | |
| Occupational Exposure Limit - UNITED KINGDOM | time-weighted average 0.025 mg(Hg)/m3, SEP2000 | |
| Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; time-weighted average 0.01; short term exposure limit 0.03 mg/m3 (skin) | |
| Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM |
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.01; short term exposure limit 0.03 mg/m3 (skin) |
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NIOSH DOCUMENTATION AND SURVEILLANCE: | ||
| ORGANIZATION | STANDARD or SURVEY |
REFERENCE |
| National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MERCURY, ARYL AND INORGANIC-air | ceiling concentration 0.1 mg/m3 (Sk) | NIOSH* DHHS #92-100,1992 |
| National Occupational Hazard Survey 1974 |
National Occupational Hazard Survey 1974: Hazard Code: 83751; Number of Industries 4; Total Number of Facilities 109; Number of Occupations 4; Total Number of Employees Exposed 856 | |
| National Occupational Exposure Survey 1983 |
National Occupational Exposure Survey 1983: Hazard Code: 83751 ;Number of Industries 11; Total Number of Facilities 320; Number of Occupations 10; Total Number of Employees Exposed 6,064; Total Number of Female Employees Exposed 2,770 |
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STATUS IN FEDERAL AGENCIES: | |
| ORGANIZATION |
REFERENCE |
| EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-mammalian oocyte | |
| EPA TSCA Section 8(b) CHEMICAL INVENTORY | |
REFERENCES: | |
| CODEN |
REFERENCE |
| AJOGAH | American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- |
| AMIHBC | AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. |
| ATSUDG | Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978- |
| BECTA6 | Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966- |
| DTLVS* | The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 |
| DTLWS* | "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8. |
| EMMUEG | Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- |
| ENVRAL | Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- |
| GISAAA | Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- |
| GTPZAB | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI |
| IMEMDT | IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- |
| LSBGAY | Life Sciences, Part 2: Biochemistry, General and Molecular Biology. (New York, NY) V.9-13, 1970-73. For publisher information, see LIFSAK. |
| MOLAAF | Monatsschrift fuer Ohrenheilkunde und Laryngo-Rhinologie. (Vienna, Austria) V.1-108, 1867-1974. For publisher information, see LROTDW. |
| MUREAV | Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- |
| NIOSH* | National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. |
| NYKZAU | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- |