The Registry of Toxic Effects of Chemical Substances

Acetic acid, mercapto -

RTECS #: AI5950000

CAS #: 68-11-1

UPDATE: November 2004 MW: 92.12 MF: C2H4O2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Glycolic acid, thio -
  2. Glycolic acid, 2 - thio -
  3. Kyselina merkaptooctova (Czech)
  4. Kyselina thioglykolova (Czech)
  5. Mercaptoacetate
  6. Mercaptoacetic acid
  7. alpha - Mercaptoacetic acid
  8. 2 - Mercaptoacetic acid
  1. Thioglycolic acid
  2. 2 - Thioglycolic acid
  3. Thioglycolic acid (ACGIH)
  4. Thioglycollic acid
  5. Thiovanic acid
  6. USAF CB - 35
  7. Acide thioglycolique (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		3% INMEAF 15,669,1946


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published lethal concentration: 7 mg/m3/2 hour N/R 85GMAT -,111,1982
inhalation
rat 		lethal concentration (50 percent kill): 210 mg/m3/4 hour Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Changes in lung weight 		NTIS** OTS0554077
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 157 mg/kg N/R ZHYGAM 20,575,1974
intraperitoneal
mouse 		lethal dose (50 percent kill): 138 mg/kg N/R ARZNAD 31,1713,1981
intraperitoneal
rat 		lethal dose (50 percent kill): 70 mg/kg N/R ZHYGAM 20,575,1974
intravenous
mouse 		lethal dose (50 percent kill): 145 mg/kg N/R NYKZAU 60,278,1964
intravenous
rabbit 		lethal dose (50 percent kill): 100 mg/kg N/R BIJOAK 41,325,1947
oral
guinea pig 		lethal dose (50 percent kill): 126 mg/kg N/R 34ZIAG -,586,1969
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 250 mg/kg N/R GISAAA 39(4),86,1974
oral
mouse 		lethal dose (50 percent kill): 242 mg/kg N/R ZHYGAM 20,575,1974
oral
rat 		lethal dose (50 percent kill): 114 mg/kg N/R ZHYGAM 20,575,1974
oral
rabbit 		lethal dose (50 percent kill): 119 mg/kg N/R ZHYGAM 20,575,1974
skin
mouse 		lethal dose (50 percent kill): 47 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		SRTCAC 36(1-4),10,1989
skin
rabbit 		lowest published lethal dose: 300 mg/kg Skin: After systemic exposure: Dermatitis, other GTPZAB 13(1),48,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1 ppm (skin) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (4 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (3.8 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (5 mg/m3), short term exposure limit 3 ppm (15 mg/m3), JAN1993
Occupational Exposure Limit - FRANCE VME 1 ppm (5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.5 mg/m3, short term exposure limit 1 mg/m3, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 4 mg/m3, Skin, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1 ppm, 3.8 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 1 ppm (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 1 ppm (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THIOGLYCOLIC ACID-air 10 hour time-weighted average 1 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83835;
Number of Industries 10;
Total Number of Facilities 5,167;
Number of Occupations 9;
Total Number of Employees Exposed 35,238
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83835;
Number of Industries 10;
Total Number of Facilities 2,428;
Number of Occupations 12;
Total Number of Employees Exposed 30,055;
Total Number of Female Employees Exposed 15,141


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used to make thioglycolates, also used in sensitivity tests for iron
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For publisher information, see IOHSA5.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955-

Used to make thioglycolates, also used in sensitivity tests for iron

NIOSH PROFILE (THIOGLYCOLIC ACID), SRC, 4/81

RTECS Compound Description:
   Agricultural Chemical
   Primary Irritant

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