The Registry of Toxic Effects of Chemical Substances

Acetic acid, isopropyl ester

RTECS #: AI4930000

CAS #: 108-21-4

UPDATE: May 2004 MW: 102.15 MF: C5H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - Acetoxypropane
  2. 2 - Propyl acetate
  3. Acetate d'isopropyle (French)
  4. Acetic acid, 1 - methylethyl ester (9CI)
  5. Isopropile (acetato di) (Italian)
  6. Isopropyl (acetate d') (French)
  1. Isopropyl acetate
  2. Isopropyl acetate (ACGIH:OSHA)
  3. Isopropylacetaat (Dutch)
  4. Isopropylacetat (German)
  5. Isopropylester kyseliny octove (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		200 ppm/15 minute N/R JIHTAB 28,262,1946
skin
rabbit 		500 mg/24 hour mild 85JCAE -,354,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 200 ppm Lung, Thorax, or Respiration: Other changes AMIHAB 21,28,1960
inhalation
rat 		lethal concentration (50 percent kill): 50,600 mg/m3/8 hour N/R AIHAAP 20,364,1959
intraperitoneal
rat 		lethal dose : >174 mg/kg N/R JSGRA2 53,572,1992
intravenous
rat 		lowest published lethal dose: 174 mg/kg N/R JSGRA2 53,572,1992
oral
rat 		lethal dose (50 percent kill): 6,750 mg/kg N/R UCDS** 3/24/1970
oral
rabbit 		lethal dose (50 percent kill): 6,946 mg/kg N/R IMSUAI 41,31,1972
skin
rabbit 		lethal dose (50 percent kill): >20 mL/kg N/R AMIHBC 10,61,1954
unreported route
human 		lowest published toxic concentration: 200 ppm Eye: Conjunctiva irritation JIHTAB 28,262,1946


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 250 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm;short term exposure limit 200 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 310 ppm DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
AMIHAB 21,28,1960


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 250 ppm (950 mg/m3) DTLVS* 3,141,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 250 ppm (950 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 250 ppm (950 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 250 ppm (950 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 250 ppm (950 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (950 mg/m3), short term exposure limit 310 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 200 ppm (840 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 250 ppm (1040 mg/m3), short term exposure limit 310 ppm (1290 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 150 ppm (625 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 250 ppm (950 mg/m3), VLE 300 ppm (1140 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 200 ppm (840 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 400 mg/m3, short term exposure limit 800 mg/m3, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 100 ppm (240 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 250 ppm (950 mg/m3), JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (840 mg/m3), KZG- week 400 ppm (1680 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 200 ppm (849 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 310 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 310 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 40984;
Number of Industries 103;
Total Number of Facilities 10,160;
Number of Occupations 67;
Total Number of Employees Exposed 84,001
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 40984;
Number of Industries 85;
Total Number of Facilities 8,643;
Number of Occupations 68;
Total Number of Employees Exposed 159,819;
Total Number of Female Employees Exposed 50,913


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an organic solvent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Isopropyl acetate, 1454


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JSGRA2 Journal of Surgical Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1961-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as an organic solvent

NIOSH PROFILE (ACETATES), SRI, 2/77

RTECS Compound Description:
   Human Data
   Primary Irritant

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