The Registry of Toxic Effects of Chemical Substances

Acetic acid, fluoro - , sodium salt

RTECS #: AH9100000

CAS #: 62-74-8

UPDATE: November 2004 MW: 100.03 MF: C2H2FO2•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Compound 1080
  2. Compound No. 1080
  3. Fluorakil 3
  4. Fluoressigaeure (German)
  5. Fluoroacetic acid, sodium salt
  6. Fluoroctan sodny (Czech)
  7. Fratol
  8. Furatol
  9. Latka 1080 (Czech)
  10. Monofluoressigsaures natrium (German)
  11. Natriumfluoracetaat (Dutch)
  12. Natriumfluoracetat (German)
  1. RCRA waste number P058
  2. Ratbane 1080
  3. Sodio, fluoracetato di (Italian)
  4. Sodium fluoacetate
  5. Sodium fluoacetic acid
  6. Sodium fluoracetate
  7. Sodium fluoroacetate
  8. Sodium fluoroacetate (ACGIH:OSHA)
  9. Sodium fluoroacetate de (French)
  10. Sodium monofluoroacetate
  11. TL 869
  12. Yasoknock


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
host-mediated assay mouse
other cell types 		5 mg/kg FOBLAN 21,244,1975


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 27,500 µg/kg (11 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct EXPEAM 21,446,1965
oral
rat 		lowest published toxic dose: 210 µg/kg (3 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JRPFA4 56,201,1979


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
domestic animal 		lethal dose (50 percent kill): 700 µg/kg N/R AJPEAG 36,1427,1946
intraperitoneal
wild bird 		lethal dose (50 percent kill): 102 mg/kg N/R AWLRAO 15,239,1988
intraperitoneal
cat 		lethal dose (50 percent kill): 300 µg/kg N/R AJPEAG 36,1427,1946
intraperitoneal
domestic animal 		lethal dose (50 percent kill): 200 µg/kg N/R AJPEAG 36,1427,1946
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 378 µg/kg N/R JPETAB 95,62,1949
intraperitoneal
mammal (species unspecified) 		lethal dose (50 percent kill): 100 µg/kg Behavioral: Convulsions or effect on seizure threshold JAPMA8 36,59,1947
intraperitoneal
mouse 		lethal dose (50 percent kill): 7 mg/kg N/R NEZAAQ 34,193,1979
intraperitoneal
pig 		lethal dose (50 percent kill): 300 µg/kg N/R AJPEAG 36,1427,1946
intraperitoneal
rat 		lethal dose (50 percent kill): 1,940 µg/kg N/R BJEPA5 50,277,1969
intraperitoneal
squirrel 		lethal dose (50 percent kill): 400 µg/kg Behavioral: Somnolence (general depressed activity) JAPMA8 36,59,1947
intravenous
dog 		lethal dose (50 percent kill): 60 µg/kg N/R YKYUA6 31,1385,1980
intravenous
domestic animal 		lowest published lethal dose: 519 µg/kg Liver: Other changes

Endocrine: Hyperglycemia

Musculoskeletal: Other changes 		JCPTA9 70,145,1960
intravenous
monkey 		lethal dose (50 percent kill): 5 mg/kg N/R AJPEAG 36,1427,1946
intravenous
rabbit 		lethal dose (50 percent kill): 300 µg/kg N/R AJPEAG 36,1427,1946
oral
wild bird 		lethal dose (50 percent kill): 2,370 µg/kg N/R AECTCV 12,355,1983
oral
cat 		lethal dose (50 percent kill): 350 µg/kg N/R JAPMA8 37,307,1948
oral
chicken 		lowest published lethal dose: 5,900 µg/kg N/R JAPMA8 36,59,1947
oral
duck 		lethal dose (50 percent kill): 4,810 µg/kg N/R TXAPA9 22,556,1972
oral
dog 		lethal dose (50 percent kill): 66 µg/kg N/R JPETAB 101,82,1951
oral
domestic animal 		lethal dose (50 percent kill): 500 µg/kg Cardiac: Other changes AWLRAO 9,487,1982
oral
frog 		lowest published lethal dose: 54 mg/kg N/R VHTODE 15,6,1973
oral
guinea pig 		lethal dose (50 percent kill): 300 µg/kg N/R AJPEAG 36,1427,1946
oral
human 		lowest published lethal dose: 714 µg/kg N/R 34ZIAG -,542,1969
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 110 µg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression 		AWLRAO 8,385,1981
oral
monkey 		lethal dose (50 percent kill): 300 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		NYKZAU 65,182,1969
oral
mouse 		lethal dose (50 percent kill): 100 µg/kg N/R YKYUA6 28,329,1977
oral
pigeon 		lethal dose (50 percent kill): 2 mg/kg N/R JAPMA8 36,59,1947
oral
quail 		lethal dose (50 percent kill): 18 mg/kg N/R TXAPA9 20,57,1971
oral
rat 		lethal dose (50 percent kill): 100 µg/kg N/R AJPEAG 36,1427,1946
oral
rabbit 		lethal dose (50 percent kill): 340 µg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		AWLRAO 9,487,1982
oral
squirrel 		lethal dose (50 percent kill): 300 µg/kg N/R AJPEAG 36,1427,1946
subcutaneous
wild bird 		lethal dose (50 percent kill): 630 µg/kg Eye: Ptosis

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		AWLRAO 11,373,1984
subcutaneous
frog 		lethal dose (50 percent kill): 1 gm/kg N/R AJPEAG 36,1427,1946
subcutaneous
guinea pig 		lethal dose (50 percent kill): 250 µg/kg N/R BCPCA6 6,169,1961
subcutaneous
mouse 		lethal dose (50 percent kill): 7,200 µg/kg N/R NDRC** 30101,2,1945
subcutaneous
rabbit 		lethal dose (50 percent kill): 281 µg/kg N/R JPETAB 95,62,1949
skin
guinea pig 		lethal dose (50 percent kill): 1,600 µg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Dyspnea 		NYKZAU 65,182,1969
skin
mouse 		lethal dose (50 percent kill): 25,300 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		NYKZAU 65,182,1969
skin
rat 		lethal dose (50 percent kill): 48 mg/kg N/R NYKZAU 65,182,1969
unreported route
horse, donkey 		lethal dose (50 percent kill): 1 mg/kg N/R AJPEAG 36,1427,1946
unreported route
man 		lowest published lethal dose: 5 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes 		AJPEAG 36,1427,1946
unreported route
mouse 		lethal dose (50 percent kill): 10 mg/kg N/R YKYUA6 30,397,1979
unreported route
rat 		lethal dose (50 percent kill): 15 mg/kg N/R YKYUA6 30,397,1979


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 6 mg/kg/3 day- intermittent Blood: Change in clotting factors

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JEMAAJ 45,694,1962
intravenous
domestic animal 		lowest published toxic dose: 519 µg/kg/3 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JCPTA9 70,145,1960
oral
chicken 		lowest published toxic dose: 20 mg/kg/3 day- intermittent Cardiac: Other changes

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JAVMA4 111,301,1947
oral
domestic animal 		lowest published toxic dose: 649 µg/kg/30 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JCPTA9 70,145,1960
oral
mammal (species unspecified) 		lowest published toxic dose: 686 mg/kg/28 day- continuous Cardiac: Changes in heart weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		ETOCDK 5,213,1986
oral
mammal (species unspecified) 		lowest published toxic dose: 8,500 µg/kg/28 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in spleen weight 		TOXID9 3,147,1983
oral
mouse 		lowest published toxic dose: 51 mg/kg/30 day- intermittent Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Cyanosis

Gastrointestinal: Alteration in gastric secretion 		NHOZAX 26,203,1972
oral
rat 		lowest published toxic dose: 19.25 mg/kg/77 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 69,439,2002
oral
rat 		lowest published toxic dose: 22.5 mg/kg/90 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Cardiac: Cardiomyopathy including infarction

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOSCF2 69,439,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 (skin) DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
IMSUAI 21,440,1952
TOXICOLOGY REVIEW
AMSSAQ 400,5,1963
TOXICOLOGY REVIEW
IMSUAI 19,535,1950


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: RED Completed RBREV* -,255,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.05 mg/m3 (skin) DTLVS* 3,232,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.05 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.05 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.05 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.05 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.05 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg/m3, short term exposure limit 0.15 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.05 mg/m3, Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 mg/m3, short term exposure limit 0.15 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.05 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.05 mg/m3, short term exposure limit 0.15 mg/m3, Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 0.05 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.05 mg/m3, Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.05 mg/m3, Skin, 2003
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.05 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 mg/m3, KZG- week 1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.05 mg/m3, Skin, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.05 mg/m3, short term exposure limit 0.15 mg/m3, Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.05 mg/m3 (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.05 mg/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO THE CHEMICAL-air time-weighted average 0.05 mg/m3;
short term exposure limit 0.15 mg/m3 (Sk) 		NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as highly toxic, immediate action rodenticide
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AJPEAG American Journal of Public Health and the Nation's Health. (New York, NY) V.18-60, 1928-70. For publisher information, see AJHEAA.
AMSSAQ Acta Medica Scandinavica, Supplement. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) No.1-730, 1921-88.
AWLRAO Australian Wildlife Research. (Commonwealth Scientific and Industrial Research Organization, 314 Albert St., E. Melbourne, Vic. 3002, Australia) V.1- 1974-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1920-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ETOCDK Environmental Toxicology and Chemistry. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1982-
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FOBLAN Folia Biologica (Prague). (Academic Press Inc. Ltd., 24-28 Oval Rd., London NW1 7DX, UK) V.1- 1955-
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JAVMA4 Journal of the American Veterinary Medical Association. (American Veterinary Medical Assoc., 930 N. Meacham Rd., Schaumburg, IL 60196) V.48- 1915-
JCPTA9 Journal of Comparative Pathology and Therapeutics. (Liverpool, UK) V.1-74, 1883-1964. For publisher information, see JCVPAR.
JEMAAJ Journal of the Egyptian Medical Association. (Egyptian Medical Assoc., 42, Sharia Kasr-El- Aini, Cairo, Egypt) V.11- 1928-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
NDRC** National Defense Research Committee, Office of Scientific Research and Development, Progress Report.
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NHOZAX Nippon Hoigaku Zasshi. Japanese Journal of Legal Medicine. (Nippon Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1944-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as highly toxic, immediate action rodenticide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Human Data

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