The Registry of Toxic Effects of Chemical Substances

Acetic acid, ethyl ester

RTECS #: AH5425000

CAS #: 141-78-6

UPDATE: November 2004 MW: 88.12 MF: C4H8O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Acetic ether
  2. Acetidin
  3. Acetoxyethane
  4. Aethylacetat (German)
  5. Essigester (German)
  6. Ethyl acetate
  7. Ethyl acetate (ACGIH:OSHA)
  8. Ethyl acetic ester
  1. Ethyl ethanoate
  2. Ethylacetaat (Dutch)
  3. Ethyle (acetate d') (French)
  4. Ethylester kyseliny octove (Czech)
  5. Etile (acetato di) (Italian)
  6. Octan etylu (Polish)
  7. RCRA waste number U112
  8. Vinegar naphtha


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		400 ppm N/R JIHTAB 25,282,1943


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster fibroblast 9 gm/L FCTOD7 22,623,1984
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 24,400 ppm MUREAV 149,339,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 61 gm/m3 N/R HBTXAC 1,336,1955
inhalation
human 		lowest published toxic concentration: 400 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes 		JIHTAB 25,282,1943
inhalation
mouse 		lethal concentration (50 percent kill): 45 gm/m3/2 hour N/R 85GMAT -,65,1982
inhalation
mouse 		lowest published toxic concentration: 200 ppm/6 minute Lung, Thorax, or Respiration: Respiratory depression TOLED5 9,137,1981
inhalation
rat 		lethal concentration (50 percent kill): 200 gm/m3 Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Changes in structure or function of salivary glands 		SRTCAC 36(1-4),10,1989
intraperitoneal
mouse 		lethal dose (50 percent kill): 709 mg/kg N/R SCCUR* -,5,1961
oral
guinea pig 		lethal dose (50 percent kill): 5,500 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Coma 		GISAAA 48(4),66,1983
oral
mouse 		lethal dose (50 percent kill): 4,100 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Coma 		GISAAA 48(4),66,1983
oral
rat 		lethal dose (50 percent kill): 5,620 mg/kg N/R YKYUA6 32,1241,1981
oral
rabbit 		lethal dose (50 percent kill): 4,935 mg/kg N/R IMSUAI 41,31,1972
subcutaneous
cat 		lethal dose (50 percent kill): 3 gm/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Nausea or vomiting

Blood: Other changes 		AGGHAR 5,1,1933
subcutaneous
guinea pig 		lethal dose (50 percent kill): 3 gm/kg Behavioral: Somnolence (general depressed activity) AGGHAR 5,1,1933
subcutaneous
rat 		lowest published lethal dose: 5 gm/kg N/R BSIBAC 18,45,1943
skin
rabbit 		lethal dose (50 percent kill): >20 mL/kg N/R UCDS** 10/4/1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 22 gm/m3/40 minute/4 week- intermittent Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature decrease 		NTIS** OTS0572401
inhalation
rat 		lowest published toxic concentration: 1,500 ppm/90 day- intermittent Olfaction: Change in sensation of smell

Olfaction: Other olfaction effects 		TOPADD 27,618,1999
intraperitoneal
rat 		lowest published toxic dose: 8 mL/kg/8 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Metabolism (intermediary): Other carbohydrates 		BECTA6 12,612,1974


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 400 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
AMIHAB 21,28,1960


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,292,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 400 ppm (1400 mg/m3) DTLVS* 3,102,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 400 ppm (1400 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 400 ppm (1400 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 400 ppm (1400 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 400 ppm (1400 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 400 ppm (1400 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 400 ppm (1400 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 400 ppm (1440 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 150 ppm (540 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 300 ppm (1100 mg/m3), short term exposure limit 500 ppm (1800 mg/m3), JAN1993
Occupational Exposure Limit - FRANCE VME 400 ppm (1400 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 400 ppm (1400 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 400 mg/m3, short term exposure limit 1200 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 550 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 150 ppm (550 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 400 ppm (1400 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 200 ppm, MAC(short term exposure limit) 600 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 400 ppm, short term exposure limit 200 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 150 ppm (500 mg/m3), KTV 300 ppm (1100 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 400 ppm (1400 mg/m3), KZG- week 800 ppm (2800 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 400 ppm (1400 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 400 ppm (1460 mg/m3), SEP2000
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 400 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL ACETATE-air 10 hour time-weighted average 400 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 31470;
Number of Industries 234;
Total Number of Facilities 37,072;
Number of Occupations 152;
Total Number of Employees Exposed 407,816
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 31470;
Number of Industries 234;
Total Number of Facilities 40,728;
Number of Occupations 154;
Total Number of Employees Exposed 504,448;
Total Number of Female Employees Exposed 119,505


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent for NITROCELLULOSE
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Ethyl acetate, 1457
NIOSH Analytical Method, 1996: Volatile organic compound, 2549


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BSIBAC Bolletino della Societe Italiana di Biologia Sperimentale. (Casa Editrice Idelson, Via A. de Gasperi, 55, 80133 Naples, Italy) V.2- 1927-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used as a solvent for NITROCELLULOSE

NIOSH PROFILE (ACETATES), SRI, 2/77

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (SPRAY PAINTING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data
   Primary Irritant

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