The Registry of Toxic Effects of Chemical Substances

Acetic acid, (ethylenedinitrilo) tetra -

RTECS #: AH4025000

CAS #: 60-00-4

UPDATE: August 2004 MW: 292.28 MF: C10H16N2O8


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Celon A
  2. Celon ATH
  3. Cheelox
  4. Cheelox BF acid
  5. Chemcolox 340
  6. Clewat TAA
  7. Complexon II
  8. 3,6 - Diazaoctanedioic acid, 3,6 - bis (carboxymethyl) -
  9. Edathamil
  10. Edetic acid
  11. EDTA
  12. EDTA (chelating agent)
  13. EDTA acid
  14. Endrate
  15. N,N' - 1,2 - Ethanediylbis (N - (carboxymethyl) glycine)
  16. Ethylenediaminetetraacetate
  17. Ethylenediaminetetraacetic acid
  18. Ethylenediamine - N,N,N',N' - tetraacetic acid
  19. Ethylenedinitrilotetraacetic acid
  20. Gluma cleanser
  21. Glycine, N,N' - 1,2 - ethanediylbis (N - (carboxymethyl) - (9CI)
  22. Hamp - ene acid
  23. Havidote
  1. ICRF 185
  2. Komplexon II
  3. Kyselina ethylendiamintetraoctova (Czech)
  4. Metaquest A
  5. Nervanaid B acid
  6. Perma kleer 50 acid
  7. Questex 4H
  8. SEQ 100
  9. Sequestrene AA
  10. Sequestric acid
  11. Sequestrol
  12. Tetrine acid
  13. Titriplex
  14. Versene acid
  15. Vinkeil 100
  16. Warkeelate acid
  17. YD 30
  18. Acide ethylenediaminetetracetique (French)
  19. Nullapon B acid
  20. Nullapon BF acid
  21. Trilon BS
  22. Trilon BW


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis intraperitoneal
mouse 		50 mmol/L CISCB7 20,28,1976
DNA damage mouse lymphocyte 40,500 µmol/L MUREAV 203,155,1988
DNA inhibition hamster fibroblast 500 µg/L ECREAL 163,191,1986
DNA inhibition rat other cell types 600 µmol/L REXMAS 192,115,1992
DNA inhibition rabbit kidney 250 µmol/L ECREAL 36,92,1964
unscheduled DNA synthesis hamster embryo 100 µmol/L SHIGAZ 74,1365,1987
micronucleus test intraperitoneal
mouse 		186 mg/kg EMMUEG 19,125,1992
micronucleus test oral
mouse 		15 mg/kg FCTOD7 29,845,1991
mutation in mammalian somatic cells mouse lymphocyte 25,200 µmol/L MUTAEX 3,193,1988
sister chromatid exchange hamster embryo 30 µmol/L SHIGAZ 74,1365,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 7,632 mg/kg (7-14 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TXAPA9 40,299,1977
oral
rat 		lowest published toxic dose: 7,632 mg/kg (7-14 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Specific developmental abnormalities: Urogenital system 		TXAPA9 40,299,1977
oral
rat 		lowest published toxic dose: 7,632 mg/kg (7-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		TXAPA9 40,299,1977
subcutaneous
rat 		lowest published toxic dose: 3 gm/kg (7-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		TXAPA9 40,299,1977


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 250 mg/kg N/R NTIS** AD691-490
intraperitoneal
rat 		lethal dose (50 percent kill): 397 mg/kg Behavioral: Convulsions or effect on seizure threshold AHRTAN 13,295,1962
intraperitoneal
rat 		lethal dose (50 percent kill): 512.9 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement

Liver: Other changes 		IJOTO* 21,95,2002
intravenous
mouse 		lethal dose (50 percent kill): 28,500 µg/kg N/R JJPAAZ 63,187,1993
oral
mouse 		lethal dose (50 percent kill): 30 mg/kg N/R FCTOD7 29,845,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
BJMRDK 34,449,2001
TOXICOLOGY REVIEW
IJOTO* 21,95,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,309,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80283;
Number of Industries 122;
Total Number of Facilities 12,157;
Number of Occupations 93;
Total Number of Employees Exposed 121,906
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80283;
Number of Industries 119;
Total Number of Facilities 14,680;
Number of Occupations 116;
Total Number of Employees Exposed 509,055;
Total Number of Female Employees Exposed 315,637


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as general purpose chelating agent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AHRTAN Arhiv za Higijenu Rada i Toksikologiju. Archives of Industrial Hygiene and Toxicology. (Jugoslovenska Knjiga, POB 36, YU-11001 Belgrade, Yugoslavia) V.7- 1956-
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
CISCB7 CIS, Chromosome Information Service. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) No.1- 1961-
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.10- 1950-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IJOTO* International Journal of Toxicology (Continous: Journal of the American College of Toxicology,Taylor & Francis Health Sciences) V.16- 1997-
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REXMAS Research in Experimental Medicine. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.157- 1972-
SHIGAZ Shigaku. Ondotology. (Nippon Shika Daigaku Shigakkai, 1-9-20 Fujimi, Chiyodaku, Tokyo 102, Japan) V.38- 1949-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as general purpose chelating agent

NIOSH PROFILE (PHOTOGRAPHIC PROCESSING), FIRL, 4/78

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector

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