The Registry of Toxic Effects of Chemical Substances

Acetic acid, (2,4 - dichlorophenoxy) -

RTECS #: AG6825000

CAS #: 94-75-7

UPDATE: May 2005 MW: 221.04 MF: C8H6Cl2O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. (2,4 - Dichloor - fenoxy) - azijnzuur (Dutch)
  2. (2,4 - Dichlor - phenoxy) - essigsaeure (German)
  3. 2,4 - D
  4. 2,4 - D (ACGIH:OSHA)
  5. 2,4 - D acid
  6. 2,4 - Dichlorophenoxy acetic acid
  7. 2,4 - Dichlorophenoxyacetic acid
  8. 2,4 - Dichlorphenoxyacetic acid
  9. 2,4 - Dwuchlorofenoksyoctowy kwas (Polish)
  10. Acide 2,4 - dichloro phenoxyacetique (French)
  11. Acido (2,4 - dicloro - fenossi) - acetico (Italian)
  12. Acme LV 4
  13. Agrotect
  14. Amidox
  15. Amoxone
  16. Aqua - Kleen
  17. B - Selektonon
  18. BH 2,4 - D
  19. Barrage
  20. Brush - rhap
  21. Chipco turf herbicide D
  22. Chloroxone
  23. Citrus fix
  24. Crop rider
  25. DMA - 4
  26. Debroussaillant 600
  27. Deherban
  28. Dichlorophenoxyacetic acid
  29. Dichlorophenoxyacetic acid (OSHA)
  30. Dicopur
  31. Dormone
  32. ENT 8,538
  33. Emulsamine BK
  34. Emulsamine E - 3
  35. Envert 171
  36. Envert DT
  37. Estone
  38. Farmco
  39. Fernimine
  1. Fernoxone
  2. Ferxone
  3. Foredex 75
  4. Hedonal (the herbicide)
  5. Herbidal
  6. Hivol - 44
  7. Ipaner
  8. Kwas 2,4 - dwuchlorofenoksyoctowy (Polish)
  9. Kwasu 2,4 - dwuchlorofenoksyoctowego (Polish)
  10. Kyselina 2,4 - dichlorfenoxyoctova (Czech)
  11. Lawn - keep
  12. Macrondray
  13. Miracle
  14. Moxone
  15. NSC 423
  16. Netagrone
  17. Netagrone 600
  18. Pennamine
  19. Pennamine D
  20. Phenox
  21. Pielik
  22. Plantgard
  23. RCRA waste number U240
  24. Rhodia
  25. Superormone concentre
  26. U 46DP
  27. U - 5043
  28. Vergemaster
  29. Verton 2D
  30. Vidon 638
  31. Weed TOX
  32. Weed - Ag - Bar
  33. Weed - rhap
  34. Weedar - 64
  35. Weedatul
  36. Weedez Wonder BAR
  37. Weedone LV4
  38. Weedtrol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		750 µg/24 hour severe 28ZPAK -,279,1972
skin
rabbit 		500 mg/24 hour mild 28ZPAK -,279,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis cattle kidney 1 ppm ITCSAF 8,416,1973
cytogenetic analysis hamster ovary 2,400 mg/L EMMUEG 10(Suppl 10),1,1987
cytogenetic analysis human lymphocyte 20 µg/L CYGEDX 8(3),6,1974
cytogenetic analysis oral
mouse 		100 mg/kg CYGEDX 8(3),6,1974
cytogenetic analysis oral
mouse 		9.9 mg/kg/3 day MUREAV 494,1,2001
cytogenetic analysis intraperitoneal
mouse 		3.5 mg/kg ARTODN 74,560,2000
cytogenetic analysis intraperitoneal
rat 		100 µg/kg CYTOAN 52,275,1987
DNA adduct Escherichia coli 20 µmol/L MUREAV 89,95,1981
DNA damage human Ascites tumor 4 mmol/L/36 hour FCTOD7 41,385,2003
DNA damage mammal (species unspecified) lymphocyte 1 mmol/L PYTCAS 11,3135,1972
DNA damage salmon sperm 1 mmol/L PYTCAS 11,3135,1972
DNA inhibition hamster ovary 1 mmol/L TOLED5 29,137,1985
DNA inhibition oral
mouse 		200 mg/kg MUREAV 55,197,1978
DNA repair Bacillus subtilis 5 mg/disc NTIS** PB80-133226
DNA repair Escherichia coli 5 mg/disc NTIS** PB80-133226
unscheduled DNA synthesis human fibroblast 1 µmol/L MUREAV 42,161,1977
mutation in microorganisms other microorganisms 1 gm/L (-enzymatic activation step) MILEDM 5,103,1977
mutation in microorganisms Salmonella typhimurium 250 µg/plate (-enzymatic activation step) MUREAV 204,615,1988
mutation in microorganisms Saccharomyes cerevisiae 150 mg/L (-enzymatic activation step) ECBUDQ 27,193,1978
mutation in microorganisms Saccharomyes cerevisiae 4 mmol/L/4 hour ARTODN 74,560,2000
micronucleus test human lymphocyte 5 µmol/L/48 hour MUREAV 521,165,2002
gene conversion and mitotic recombination Aspergillus nidulans 4 µmol/L MUREAV 204,615,1988
mutation in mammalian somatic cells hamster lung 10 µmol/L CBINA8 19,369,1977
sister chromatid exchange hamster ovary 167 mg/L EMMUEG 10(Suppl 10),1,1987
sister chromatid exchange human lymphocyte 10 mg/L JOHEA8 73,224,1982
sister chromatid exchange oral
mouse 		100 mg/kg FCTOD7 39,941,2001
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		25 ppm ECBUDQ 27,190,1978
sex chromosome loss and nondisjunction unreported route
Drosophila melanogaster 		1,000 ppm/15 day ECBUDQ 27,182,1978
specific locus test oral
Drosophila melanogaster 		5 mmol/L MUREAV 319,237,1993
specific locus test multiple
Drosophila melanogaster 		10 ppb EMMUEG 25,148,1995
sperm morphology oral
mouse 		33 mg/kg MUREAV 494,1,2001


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 1,600 mg/kg (9-25 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic 		NETEEC 18,691,1996
intraperitoneal
rat 		lowest published toxic dose: 600 mg/kg (9-15 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Biochemical and metabolic 		NETEEC 18,691,1996
intraperitoneal
rat 		lowest published toxic dose: 1 gm/kg (15-24 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic NETEEC 18,691,1996
intraperitoneal
rat 		lowest published toxic dose: 700 mg/kg (9-15 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NETEEC 25,607,2003
intraperitoneal
rat 		lowest published toxic dose: 1,700 mg/kg (9-25 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Other postnatal measures or effects 		NETEEC 25,607,2003
oral
hamster 		lowest published toxic dose: 200 mg/kg (7-11 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) BECTA6 6,559,1971
oral
mammal (species unspecified) 		lowest published toxic dose: 20 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) FEREAC 67,10624,2002
oral
mammal (species unspecified) 		lowest published toxic dose: 750 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FEREAC 67,10624,2002
oral
mouse 		lowest published toxic dose: 707 mg/kg (11-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		AECTCV 6,33,1977
oral
mouse 		lowest published toxic dose: 900 mg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)

Reproductive: Specific developmental abnormalities: Eye, ear 		NTIS** PB223-160
oral
mouse 		lowest published toxic dose: 438 mg/kg (8-12 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TCMUD8 7,7,1987
oral
mouse 		lowest published toxic dose: 715 mg/kg (6-16 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects 		TXCYAC 165,39,2001
oral
mouse 		lowest published toxic dose: 7,150 mg/kg (6-16 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Other postnatal measures or effects 		TXCYAC 165,39,2001
oral
mouse 		lowest published toxic dose: 407 mg/kg (6-16 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) VHTODE 42,129,2000
oral
rat 		lowest published toxic dose: 220 µg/kg (1-22 day pregnant) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) GISAAA 50(10),76,1985
oral
rat 		lowest published toxic dose: 1 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		TXAPA9 22,14,1972
oral
rat 		lowest published toxic dose: 125 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FCTXAV 9,801,1971
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Urogenital system 		FCTXAV 9,801,1971
oral
rat 		lowest published toxic dose: 80 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system CKSCDN 24,29,1998
oral
rat 		lowest published toxic dose: 3,150 mg/kg (16-22 day pregnant/23 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic 		NRTXDN 24,149,2003
oral
rat 		lowest published toxic dose: 400 mg/kg (7-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus 		GISAAA 40,102,1975
oral
rat 		lowest published toxic dose: 70 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic 		NRTXDN 24,149,2003
oral
rat 		lowest published toxic dose: 2,100 mg/kg (16-22 day pregnant/23 day after birth) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Delayed effects 		NRTXDN 24,149,2003
oral
rat 		lowest published toxic dose: 70 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Biochemical and metabolic

Reproductive: Effects on newborn: Delayed effects 		NRTXDN 24,149,2003
subcutaneous
mouse 		lowest published toxic dose: 882 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) 		NTIS** PB223-160
subcutaneous
mouse 		lowest published toxic dose: 900 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		NTIS** PB223-160
subcutaneous
mouse 		lowest published toxic dose: 900 mg/kg (6-14 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		NTIS** PB223-160


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 32,850 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Brain and Coverings: Tumors 		FEREAC 67,10624,2002


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 1.79 gm/m3 N/R FEREAC 67,10625,2002
inhalation
rat 		lethal concentration (50 percent kill): 1.8 gm/m3 N/R FEREAC 67,10624,2002
inhalation
rabbit 		lethal concentration (50 percent kill): 1,800 mg/m3 N/R PESFO* -,253,1998
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 666 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Muscle weakness

Behavioral: Coma 		JIHTAB 29,85,1947
intraperitoneal
mouse 		lowest published lethal dose: 125 mg/kg N/R TXAPA9 23,288,1972
intraperitoneal
rat 		lethal dose (50 percent kill): 666 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Muscle weakness

Behavioral: Coma 		JIHTAB 29,85,1947
intraperitoneal
rabbit 		lethal dose (50 percent kill): 400 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Muscle weakness

Behavioral: Coma 		JIHTAB 29,85,1947
intravenous
rabbit 		lethal dose (50 percent kill): 400 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Muscle weakness

Behavioral: Coma 		JIHTAB 29,85,1947
oral
wild bird 		lethal dose (50 percent kill): 200 mg/kg N/R PESFO* -,253,1998
oral
chicken 		lethal dose (50 percent kill): 541 mg/kg Gastrointestinal: Gastritis

Behavioral: Somnolence (general depressed activity)

Liver: Fatty liver degeneration 		AJVRAH 15,622,1954
oral
dog 		lethal dose (50 percent kill): 100 mg/kg Behavioral: Stiffness

Behavioral: Coma 		AEHLAU 7,202,1963
oral
dog 		lowest published toxic dose: 200 mg/kg Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Changes in: Ca 		JTCTDW 38,747,2000
oral
dog 		lowest published toxic dose: 200 mg/kg Behavioral: Muscle contraction or spasticity

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Changes in: Ca 		JTCTDW 38,747,2000
oral
guinea pig 		lethal dose (50 percent kill): 469 mg/kg N/R AJVRAH 15,622,1954
oral
hamster 		lethal dose (50 percent kill): 500 mg/kg N/R TXAPA9 48,A192,1979
oral
human 		lowest published lethal dose: 80 mg/kg Gastrointestinal: Nausea or vomiting

Behavioral: Coma

Behavioral: Somnolence (general depressed activity) 		ARPAAQ 94,270,1972
oral
human 		lowest published toxic dose: 66 mg/kg N/R HBPTO* 1,60,2001
oral
human 		lowest published toxic dose: 694.4 mg/kg Behavioral: Somnolence (general depressed activity)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		DRSAEA 5,,1990
oral
human 		lowest published toxic dose: 66 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Behavioral: Alteration of classical conditioning 		HBPTO* 1,60,2001
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 375 mg/kg N/R SCIEAS 165,465,1969
oral
man 		lowest published toxic dose: 2 gm/kg Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression 		ARTODN 66,518,1992
oral
man 		lowest published toxic dose: 5,714 mg/kg Behavioral: Coma

Cardiac: Change in rate

Lung, Thorax, or Respiration: Respiratory depression 		ARTODN 66,518,1992
oral
man 		lowest published lethal dose: 93 mg/kg Behavioral: Convulsions or effect on seizure threshold PAREAQ 14,225,1962
oral
mouse 		lethal dose (50 percent kill): 347 mg/kg N/R RPZHAW 31,373,1980
oral
mouse 		lowest published toxic dose: 200 mg/kg Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Body temperature decrease 		FCTOD7 39,941,2001
oral
rat 		lethal dose (50 percent kill): 375 mg/kg N/R FMCHA2 -,C174,1991
oral
rat 		lethal dose (50 percent kill): 3,670 mg/kg/18 hour N/R TOIZAG 19,356,1972
oral
rabbit 		lowest published lethal dose: 800 mg/kg N/R AMPMAR 12,26,1951
oral
rabbit 		lethal dose (50 percent kill): 699 mg/kg N/R PESFO* -,253,1998
skin
rat 		lethal dose (50 percent kill): 1,500 mg/kg N/R WRPCA2 9,119,1970
skin
rabbit 		lethal dose (50 percent kill): 1,400 mg/kg Behavioral: Ataxia

Skin: After topical application: Primary irritation 		AFDOAQ 16,3,1952
skin
rabbit 		lethal dose (50 percent kill): 2,000 mg/kg N/R FEREAC 67,10624,2002
unreported route
rat 		lowest published toxic dose: 227 mg/kg Behavioral: Muscle weakness FEREAC 67,10624,2002


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
dog 		lowest published toxic dose: 300 mg/kg/6 day- intermittent Musculoskeletal: Changes in teeth and supporting structures

Skin: After systemic exposure: Dermatitis, other

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JIHTAB 29,85,1947
oral
dog 		lowest published toxic dose: 700 mg/kg/90 day- intermittent Blood: Changes in other cell count (unspecified)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AMIHBC 7,61,1953
oral
dog 		lowest published toxic dose: 1,820 mg/kg/52 week- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Liver: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		FAATDF 29,78,1996
oral
hamster 		lowest published toxic dose: 50,400 mg/kg/12 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) JTPAE7 29,440,2001
oral
mouse 		lowest published toxic dose: 91 gm/kg/2 year- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight 		FAATDF 33,166,1996
oral
mouse 		lowest published toxic dose: 18,144 mg/kg/12 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JTPAE7 29,440,2001
oral
mouse 		lowest published toxic dose: 23.4 mg/kg/9 day- intermittent Kidney, Ureter, and Bladder: Other changes

Immunological Including Allergic: Increase in cellular immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TXCYAC 177,143,2002
oral
mouse 		lowest published toxic dose: 630 mg/kg/9 day- intermittent Kidney, Ureter, and Bladder: Interstitial nephritis

Immunological Including Allergic: Increase in cellular immune response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TXCYAC 177,143,2002
oral
rat 		lowest published toxic dose: 54,600 mg/kg/2 year- continuous Liver: Changes in liver weight

Endocrine: Changes in thyroid weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		FAATDF 33,166,1996
oral
rat 		lowest published toxic dose: 13,650 mg/kg/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain FAATDF 9,423,1987
oral
rat 		lowest published toxic dose: 200 mg/kg/5 week- intermittent Behavioral: Muscle weakness NTOTDY 5,331,1983
oral
rat 		lowest published toxic dose: 54,750 mg/kg/1 year- continuous Eye: Retinal changes pigmentary deposition, retinitis, other)

Behavioral: Change in motor activity (specific assay) 		TOXID9 15,23,1995
oral
rat 		lowest published toxic dose: 3,780 mg/kg/12 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight 		JTPAE7 29,440,2001
oral
rat 		lowest published toxic dose: 418.3 mg/kg/12 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) JTPAE7 29,440,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Human Limited Evidence IMEMDT 41,357,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 15,111,1977
TOXICOLOGY REVIEW
CRTXB2 32,233,2002
TOXICOLOGY REVIEW
TOLED5 127,101,2002
TOXICOLOGY REVIEW
RREVAH 56,107,1975
TOXICOLOGY REVIEW
ECMAAI 14,141,1973
TOXICOLOGY REVIEW
BIOGAL 40(2),44,1974
TOXICOLOGY REVIEW
HYSAAV 31(7-9),383,1966
TOXICOLOGY REVIEW
JACTDZ 11,5,1992
TOXICOLOGY REVIEW
JTCTDW 38,111,2000
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
MUREAV 567,109,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,70,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 10 mg/m3 DTLVS* 3,67,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 10 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 10 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 10 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 10 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 10 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 5 mg/m3, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 10 mg/m3, JAN1999
Occupational Exposure Limit - GERMANY MAK 1 mg/m3, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 1 mg/m3, short term exposure limit 2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 7 mg/m3, MAC(short term exposure limit) 20 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 10 mg/m3, KZG- week 50 mg/m3, JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 10 mg/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 10 mg/m3, short term exposure limit 20 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 2,4-D-air 10 hour time-weighted average 10 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 24270;
Number of Industries 6;
Total Number of Facilities 1,132;
Number of Occupations 8;
Total Number of Employees Exposed 6,266
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 24270;
Number of Industries 1;
Total Number of Facilities 94;
Number of Occupations 1;
Total Number of Employees Exposed 471


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: In vivo cytogenetics-nonhuman bone marrow
EPA GENETOX PROGRAM 1988, Positive: In vitro cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-nondisjunction
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: Carcinogenicity-mouse/rat; Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a defoliant and herbicide
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: 2,4-D, 5001
NTP Carcinogenesis studies; test completed (peer review), October 2000


REFERENCES:

CODEN
REFERENCE
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Used as a defoliant and herbicide

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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