The Registry of Toxic Effects of Chemical Substances

Acetic acid, chloro -

RTECS #: AF8575000

CAS #: 79-11-8

UPDATE: February 2005 MW: 94.50 MF: C2H3ClO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Kyselina chloroctova (Czech)
  2. NCI - C60231
  3. Acide chloracetique (French)
  4. Acide monochloracetique (French)
  5. Acidomonocloroacetico (Italian)
  6. Chloracetic acid
  7. Chloroacetic acid
  8. alpha - Chloroacetic acid
  1. Chloroethanoic acid
  2. MCA
  3. Monochloorazijnzuur (Dutch)
  4. Monochloracetic acid
  5. Monochloressigsaeure (German)
  6. Monochloroacetic acid
  7. Monochloroethanoic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
mouse 		0.5 ppb EMMUEG 39,69,2002
cytogenetic analysis oral
rat 		0.5 ppb EMMUEG 39,69,2002
DNA damage hamster ovary 0.411 mmol/L/4 hour EMMUEG 40,134,2002
mutation in microorganisms mouse lymphocyte 548 mg/L (+enzymatic activation step) MUREAV 97,49,1982
mutation in mammalian somatic cells mouse lymphocyte 400 mg/L ENMUDM 9,143,1987
sister chromatid exchange hamster ovary 160 mg/L EMMUEG 10(Suppl 10),1,1987
specific locus test mouse other cell types 5 mg/L/4 hour (+enzymatic activation step) EMMUEG 38,69,2001
specific locus test oral
mouse 		0.5 ppb EMMUEG 39,69,2002
specific locus test oral
rat 		0.5 ppb EMMUEG 39,69,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 100 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		NTIS** PB223-159
subcutaneous
mouse 		toxic dose : 1,300 mg/kg/65 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		JNCIAM 53,695,1974


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 180 mg/m3 N/R GTPZAB 18(9),32,1974
intraperitoneal
rat 		lethal dose (50 percent kill): 16,600 µg/kg N/R RPTOAN 41,113,1978
oral
rat 		lethal dose (50 percent kill): 55 mg/kg N/R GTPZAB 18(9),32,1974
oral
rat 		lowest published lethal dose: 225 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma 		TOSCF2 76,51,2003
subcutaneous
mouse 		lethal dose (50 percent kill): 250 mg/kg N/R AIPTAK 116,154,1958
subcutaneous
rat 		lethal dose (50 percent kill): 5 mg/kg N/R TXAPA9 22,303,1972
skin
rat 		lowest published lethal dose: 125 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma 		TOSCF2 76,51,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 20,800 µg/m3/17 week- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Pigmented or nucleated red blood cells 		GTPZAB 18(9),32,1974
inhalation
rat 		lowest published toxic concentration: 20,800 µg/m3/17 week- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Pigmented or nucleated red blood cells 		GTPZAB 18(9),32,1974
oral
mouse 		lowest published toxic dose: 13 gm/kg/13 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-396,1992
oral
mouse 		lowest published toxic dose: 3,840 mg/kg/16 day- intermittent Eye: Lacrimation

Behavioral: Ataxia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-396,1992
oral
mouse 		lowest published toxic dose: 25,750 mg/kg/103 week- intermittent Blood: Lymphoma including Hodgkin's disease

Tumorigenic: Active as anti-cancer agent 		NTIS** PB92-189372
oral
rat 		lowest published toxic dose: 9,750 mg/kg/13 week- intermittent Cardiac: Other changes

Blood: Changes in erythrocyte (RBC) count

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-396,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
APTOA6 11,13,1955
TOXICOLOGY REVIEW
MUREAV 5432012003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - POLAND MAC(time-weighted average) 2 mg/m3, MAC(short term exposure limit) 4 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN time-weighted average 1 ppm (4 mg/m3), short term exposure limit 2 ppm (8 mg/m3), Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.3 ppm (1.2 mg/m3), Skin, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 4 mg/m3, Skin, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 18070;
Number of Industries 9;
Total Number of Facilities 1,196;
Number of Occupations 14;
Total Number of Employees Exposed 4,726
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 18070;
Number of Industries 12;
Total Number of Facilities 265;
Number of Occupations 20;
Total Number of Employees Exposed 10,912;
Total Number of Female Employees Exposed 1,723


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate in synthesis of SODIUM CARBOXYMETHYL CELLULOSE and synthetic CAFFEINE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Chloroacetic acid, 2008
NCI Carcinogenesis Studies (gavage);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as intermediate in synthesis of SODIUM CARBOXYMETHYL CELLULOSE and synthetic CAFFEINE

NIOSH PROFILE (MOLYBDENUM AND ITS COMPOUNDS), SRC, 12/79

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

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