The Registry of Toxic Effects of Chemical Substances

Acetic acid, butyl ester

RTECS #: AF7350000

CAS #: 123-86-4

UPDATE: February 2005 MW: 116.18 MF: C6H12O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1 - Butyl acetate
  2. Acetate de butyle (French)
  3. Acetic acid n - butyl ester
  4. Butile (acetati di) (Italian)
  5. Butyl acetate (OSHA)
  6. Butyl ethanoate
  7. Butylacetat (German)
  1. Butylacetaten (Dutch)
  2. Butyle (acetate de) (French)
  3. Butylester kyseliny octove (Czech)
  4. Octan n - butylu (Polish)
  5. n - Butyl acetate
  6. n - Butyl acetate (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
human 		300 ppm N/R JIHTAB 25,282,1943
eye
rabbit 		100 mg moderate ATDAEI 1,196,1992
skin
rabbit 		500 mg/24 hour moderate FCTXAV 17,515,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,500 ppm/7 hour (7-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		NTIS** PB83-258038


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 68 gm/m3/72 minute Behavioral: General anesthetic

Gastrointestinal: Changes in structure or function of salivary glands

Lung, Thorax, or Respiration: Emphysema 		AGGHAR 5,1,1933
inhalation
guinea pig 		lowest published lethal concentration: 67 gm/m3/4 hour Eye: Other eye effects

Behavioral: Antipsychotic 		FCTXAV 17,515,1979
inhalation
human 		lowest published toxic concentration: 200 ppm Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Other changes 		JIHTAB 25,282,1943
inhalation
mammal (species unspecified) 		lethal concentration (50 percent kill): 40 gm/m3 N/R GTPZAB 32(10),25,1988
inhalation
mouse 		lethal concentration (50 percent kill): 6 gm/m3/2 hour N/R YKYUA6 32,1241,1981
inhalation
rat 		lethal concentration (50 percent kill): 390 ppm/4 hour Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage 		INHTE5 9,623,1997
intramuscular
guinea pig 		lowest published lethal dose: 2,648 mg/kg Behavioral: Muscle weakness JPETAB 76,189,1942
intraperitoneal
guinea pig 		lowest published lethal dose: 1,500 mg/kg Liver: Fatty liver degeneration

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		AIHAAP 35,21,1974
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,230 mg/kg N/R SCCUR* -,2,1961
oral
guinea pig 		lethal dose (50 percent kill): 4,700 mg/kg N/R 85GMAT -,28,1982
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 4,300 mg/kg N/R GTPZAB 32(10),25,1988
oral
mouse 		lethal dose (50 percent kill): 6 gm/kg N/R GTPZAB 25(11),57,1981
oral
rat 		lethal dose (50 percent kill): 10,768 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Liver: Other changes 		ATDAEI 1,196,1992
oral
rabbit 		lethal dose (50 percent kill): 3,200 mg/kg N/R 85GMAT -,28,1982
skin
rabbit 		lethal dose (50 percent kill): >17,600 mg/kg N/R NPIRI* 1,7,1974
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 1,592 mg/kg N/R GISAAA 51(5),61,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1,500 ppm/6 hour/13 week- intermittent Behavioral: Somnolence (general depressed activity)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 36(1,pt2),61,1997
inhalation
rat 		lowest published toxic concentration: 1,500 ppm/6 hour/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight

Endocrine: Changes in adrenal weight 		FCTOD7 39,877,2001
inhalation
rat 		lowest published toxic concentration: 3,000 ppm/6 hour/13 week- continuous Brain and Coverings: Changes in brain weight

Endocrine: Changes in spleen weight

Endocrine: Changes in adrenal weight 		FCTOD7 39,877,2001
inhalation
rat 		lowest published toxic concentration: 1,500 ppm/6 hour/13 week- continuous Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTOD7 39,877,2001
inhalation
rat 		lowest published toxic concentration: 3,000 ppm/6 hour/13 week- continuous Olfaction: Other olfaction effects FCTOD7 39,877,2001
inhalation
rat 		lowest published toxic concentration: 1,500 ppm/6 hour/30 day- continuous Nutritional and Gross Metabolic: Changes in: Na

Nutritional and Gross Metabolic: Changes in: Cl 		FCTOD7 39,877,2001
inhalation
rat 		lowest published toxic concentration: 3,000 ppm/6 hour/30 day- continuous Nutritional and Gross Metabolic: Changes in: Na FCTOD7 39,877,2001
inhalation
rat 		lowest published toxic concentration: 1,500 ppm/6 hour/90 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases FCTOD7 39,877,2001
inhalation
rat 		lowest published toxic concentration: 3,000 ppm/6 hour/90 day- continuous Blood: Changes in erythrocyte (RBC) count FCTOD7 39,877,2001
inhalation
rat 		lowest published toxic concentration: 3,000 ppm/6 hour/90 day- continuous Blood: Changes in erythrocyte (RBC) count

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		FCTOD7 39,877,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 150 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 200 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
AMIHAB 21,28,1960
TOXICOLOGY REVIEW
MUREAV 5641792004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 150 ppm (700 mg/m3) DTLVS* 3,30,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 150 ppm (710 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 150 ppm (710 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 150 ppm (710 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 150 ppm (710 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 150 ppm (710 mg/m3), short term exposure limit 200 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 150 ppm (700 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 150 ppm (713 mg/m3), short term exposure limit 200 ppm (950 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 150 ppm (710 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 150 ppm (710 mg/m3), short term exposure limit 200 ppm (950 mg/m3), JAN1993
Occupational Exposure Limit - FRANCE VME 150 ppm (710 mg/m3), VLE 200 ppm (940 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 200 ppm (950 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 200 mg/m3, short term exposure limit 600 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 710 mg/m3, 2003
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 100 ppm (475 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 75 ppm (355 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 150 ppm (710 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 200 mg/m3, MAC(short term exposure limit) 950 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 200 ppm, short term exposure limit 200 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 100 ppm (500 mg/m3), KTV 150 ppm (700 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 150 ppm (700 mg/m3), KZG- week 300 ppm, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 150 ppm (710 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 150 ppm (724 mg/m3), short term exposure limit 200 ppm (966 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 200 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 200 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO n-BUTYL ACETATE-air 10 hour time-weighted average 150 ppm;
short term exposure limit 200 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 14380;
Number of Industries 280;
Total Number of Facilities 52,224;
Number of Occupations 153;
Total Number of Employees Exposed 527,992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 14380;
Number of Industries 271;
Total Number of Facilities 55,011;
Number of Occupations 164;
Total Number of Employees Exposed 822,099;
Total Number of Female Employees Exposed 143,606


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in lacquer-type coatings and in various solvents
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Esters I, 1450
NIOSH Analytical Method, 1996: Volatile organic compound, 2549


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used in lacquer-type coatings and in various solvents

NIOSH PROFILE (ACETATES), SRI, 2/77

NIOSH PROFILE (n-BUTYL ACETATE), SRC, 12/79

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (SPRAY PAINTING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

RTECS Compound Description:
   Reproductive Effector
   Human Data
   Primary Irritant

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