The Registry of Toxic Effects of Chemical Substances

Acetic acid, benzyl ester

RTECS #: AF5075000

CAS #: 140-11-4

UPDATE: February 2005 MW: 150.19 MF: C9H10O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. NCI - C06508
  2. Acetic acid, phenylmethyl ester
  3. alpha - Acetoxytoluene
  4. Benzyl acetate
  1. Benzyl acetate (ACGIH)
  2. Benzylester kyseliny octove (Czech)
  3. Benzyl ethanoate
  4. Phenylmethyl acetate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		100 mg/24 hour moderate CTOIDG 94(8),41,1979


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 600 mg/L MUREAV 369,243,1996
cytogenetic analysis oral
mouse 		0.5 ppb EMMUEG 39,69,2002
cytogenetic analysis oral
mouse 		2.4 µg/kg EMMUEG 39,69,2002
cytogenetic analysis oral
rat 		0.5 ppb EMMUEG 39,69,2002
cytogenetic analysis oral
rat 		0.125 µg/kg EMMUEG 39,69,2002
DNA repair Bacillus subtilis 21 mg/disc OIGZDE 34,267,1985
mutation in microorganisms human lymphocyte 1,500 mg/L (+enzymatic activation step) MUREAV 196,61,1988
mutation in microorganisms mouse lymphocyte 500 mg/L (+enzymatic activation step) MUREAV 196,61,1988
mutation in mammalian somatic cells mouse lymphocyte 700 mg/L SCIEAS 236,933,1987
other mutation test systems oral
mouse 		1,600 mg/kg MUREAV 343,157,1995
phage inhibition capacity Escherichia coli 6,250 ng/well MUREAV 260,349,1991
specific locus test oral
mouse 		0.5 ppb EMMUEG 39,69,2002
specific locus test oral
mouse 		2.4 µg/kg EMMUEG 39,69,2002
specific locus test oral
rat 		0.5 ppb EMMUEG 39,69,2002
specific locus test oral
rat 		0.125 µg/kg EMMUEG 39,69,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 258 gm/kg/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		NTPTR* NTP-TR-250,1986
oral
mouse 		lowest published toxic dose: 515,000 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Gastrointestinal: Tumors 		NTIS** PB87-115044
oral
rat 		lowest published toxic dose: 258 gm/kg/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors 		NTPTR* NTP-TR-250,1986
oral
rat 		lowest published toxic dose: 257,500 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Reproductive: Other reproductive system tumors 		NTIS** PB87-115044


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lethal concentration (50 percent kill): 245 ppm/8 hour N/R AMIHAB 21,28,1960
inhalation
human 		lowest published toxic concentration: 50 ppm Behavioral: Antipsychotic

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes 		TGNCDL 2,31,1961
inhalation
human 		lowest published toxic concentration: 0.15 mg/m3 Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Cough 		GISAAA -,7,1993
inhalation
mouse 		lowest published lethal concentration: 1,300 mg/m3/22 hour Behavioral: General anesthetic AGGHAR 5,1,1933
oral
guinea pig 		lethal dose (50 percent kill): 2,200 mg/kg N/R GISAAA 50(7),17,1985
oral
mouse 		lethal dose (50 percent kill): 830 mg/kg N/R GISAAA 50(7),17,1985
oral
rat 		lethal dose (50 percent kill): 2,490 mg/kg Behavioral: Somnolence (general depressed activity) FCTXAV 2,327,1964
oral
rabbit 		lethal dose (50 percent kill): 2,200 mg/kg N/R GISAAA 50(7),17,1985
subcutaneous
guinea pig 		lowest published lethal dose: 3 gm/kg N/R AGGHAR 5,1,1933
subcutaneous
rabbit 		lowest published lethal dose: 4 gm/kg Behavioral: Convulsions or effect on seizure threshold AGGHAR 5,1,1933
skin
cat 		lowest published lethal dose: 10 gm/kg Behavioral: Tremor

Behavioral: Muscle weakness

Gastrointestinal: Changes in structure or function of salivary glands 		JPETAB 84,358,1945
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R FCTXAV 11,875,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mammal (species unspecified) 		lowest published toxic dose: 4,200 mg/kg/21 day- intermittent Brain and Coverings: Recordings from specific areas of CNS

Blood: Pigmented or nucleated red blood cells

Blood: Changes in erythrocyte (RBC) count 		GISAAA 50(7),17,1985
oral
mouse 		lowest published toxic dose: 271 gm/kg/13 week- continuous Behavioral: Tremor

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-431,1993
oral
mouse 		lowest published toxic dose: 28 gm/kg/14 day- intermittent Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-250,1986
oral
rat 		lowest published toxic dose: 355 gm/kg/13 week- continuous Brain and Coverings: Other degenerative changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-431,1993
oral
rat 		lowest published toxic dose: 65 gm/kg/13 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-250,1986
oral
rat 		lowest published toxic dose: 42.5 gm/kg/17 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain EVHPAZ 68,197,1986
oral
rat 		lowest published toxic dose: 321.3 gm/kg/17 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain EVHPAZ 68,197,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 10 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 40,109,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1255,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 40,109,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1255,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1255,1999
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 5432012003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 01600;
Number of Industries 11;
Total Number of Facilities 512;
Number of Occupations 42;
Total Number of Employees Exposed 93,580
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 01600;
Number of Industries 107;
Total Number of Facilities 17,141;
Number of Occupations 108;
Total Number of Employees Exposed 275,806;
Total Number of Female Employees Exposed 133,629


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a solvent and emulsifier
NTP Carcinogenesis Studies (gavage);some evidence:mouse,rat NTPTR* NTP-TR-250,1986
NCI Carcinogenesis Studies (gavage);equivocal evidence:mouse
NCI Carcinogenesis Studies (feed);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
OIGZDE Osaka-shi Igakkai Zasshi. Journal of Osaka City Medical Association. (Osaka-shi Igakkai, c/o Osaka-shiritsu Daigaku Igakubu, 1-4-54 Asahi-cho, Abeno-ku, Osaka, 545, Japan) V.24- 1975-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
TGNCDL "Handbook of Organic Industrial Solvents," 2nd ed., Chicago, National Assoc. of Mutual Casualty Companies, 1961

Used as a solvent and emulsifier

NIOSH PROFILE (ACETATES), SRI, 2/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Natural Product
   Primary Irritant

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