The Registry of Toxic Effects of Chemical Substances

Acetanilide, 2 - chloro - 2',6' - diethyl - N - (methoxymethyl) -

RTECS #: AE1225000

CAS #: 15972-60-8

UPDATE: August 2004 MW: 269.80 MF: C14H20ClNO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Acetamide, 2 - chloro - N - (2,6 - diethylphenyl) - N - (methoxymethyl) - (9CI)
  2. Lasso
  3. Lasso micro - tech
  4. LAZO
  5. Alachlor
  6. Alachlore
  7. Alanex
  8. Alanox
  9. Alatox 480
  1. Alochlor
  2. Chloressigsaeure - N - (methoxymethyl) - 2,6 - diaethylanilid (German)
  3. 2 - Chloro - 2',6' - diethyl - N - (methoxymethyl) acetanilide
  4. 2 - Chloro - N - (2,6 - diethyl) phenyl - N - methoxymethylacetamide
  5. CP 50144
  6. Methachlor
  7. Metachlor
  8. Pillarzo


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 10 mg/L MUREAV 188,241,1987
cytogenetic analysis human lymphocyte 1 mg/L EMMUEG 19,77,1992
cytogenetic analysis oral
mouse 		72 mg/kg/30 day- continuous EMMUEG 19,77,1992
cytogenetic analysis intraperitoneal
rat 		1,250 µg/kg MUREAV 116,341,1983
cytogenetic analysis oral
rat 		11.34 gm/kg/90 day- continuous TOXID9 72(Supp 1),228,2003
DNA damage human lymphocyte 5 mg/L MUREAV 344,41,1995
mutation in microorganisms other microorganisms 90 mg/L (-enzymatic activation step) JASIAB 104,571,1985
mutation in microorganisms Salmonella typhimurium 8 µg/plate (+enzymatic activation step) KHZDAN 29(1),26,1986
micronucleus test human lymphocyte 40 mg/L MUREAV 441,95,1999
gene conversion and mitotic recombination Saccharomyes cerevisiae 33 µg/plate MUREAV 136,233,1984
mutation in mammalian somatic cells mouse lymphocyte 5,620 µg/L TOSCF2 49,202,1999
other mutation test systems oral
mouse 		216 mg/kg/90 day- continuous EMMUEG 19,77,1992
sister chromatid exchange hamster ovary 10 µmol/L MUREAV 395,159,1997
sister chromatid exchange human lymphocyte 10 µmol/L MUREAV 395,159,1997
sister chromatid exchange human lymphocyte 5 mg/L MUREAV 441,95,1999
specific locus test oral
Drosophila melanogaster 		1 mmol/L MUREAV 280,291,1992


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 142 gm/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		TIHEEC 3,383,1987
oral
rat 		lowest published toxic dose: 102 gm/kg/2.2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors

Endocrine: Thyroid tumors 		NNGADV 24,75,1999


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >23,400 mg/m3/6 hour N/R 85JFAN A004,1984
inhalation
rabbit 		lethal concentration (50 percent kill): >5,100 mg/m3 N/R TIHEEC 3,383,1987
intraperitoneal
rat 		lowest published lethal dose: 600 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		TOXID9 48,392,1999
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 3 gm/kg N/R GUCHAZ 6,3,1973
oral
mouse 		lethal dose (50 percent kill): 462 mg/kg N/R GTPZAB 21(12),30,1977
oral
rat 		lethal dose (50 percent kill): 930 mg/kg N/R TIHEEC 3,383,1987
oral
rabbit 		lethal dose (50 percent kill): 1,740 mg/kg N/R NNGADV 24,75,1999
skin
rat 		lethal dose (50 percent kill): 1,200 mg/kg N/R YKYUA6 38,89,1987
skin
rabbit 		lethal dose (50 percent kill): 3,500 mg/kg N/R GUCHAZ 6,3,1973
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 1,200 mg/kg N/R 30ZDA9 -,126,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 300 mg/kg/3 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		TXAPA9 193,66,2003
oral
dog 		lowest published toxic dose: 4,725 mg/kg/27 week- intermittent Liver: Other changes

Blood: Normocytic anemia

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NNGADV 24,75,1999
oral
dog 		lowest published toxic dose: 1,092 mg/kg/1 year- intermittent Gastrointestinal: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Normocytic anemia 		NNGADV 24,75,1999
oral
dog 		lowest published toxic dose: 910 mg/kg/26 week- intermittent Liver: Changes in liver weight RCTOE4 104,9,1988
oral
mouse 		lowest published toxic dose: 2,100 mg/kg/21 day- intermittent Liver: Liver function tests impaired

Liver: Changes in liver weight 		AECTCV 24,449,1993
oral
mouse 		lowest published toxic dose: 16,380 mg/kg/13 week- continuous Liver: Changes in liver weight NNGADV 24,75,1999
oral
mouse 		lowest published toxic dose: 43,134 mg/kg/79 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		NNGADV 24,75,1999
oral
rat 		lowest published toxic dose: 15,120 mg/kg/17 week- continuous Liver: Changes in liver weight

Endocrine: Changes in thyroid weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		FAATDF 33,16,1996
oral
rat 		lowest published toxic dose: 10,192 mg/kg/2 year- intermittent Eye: Corneal damage

Liver: Other changes 		RCTOE4 104,9,1988
oral
rat 		lowest published toxic dose: 15,120 mg/kg/120 day- continuous Liver: Changes in liver weight

Endocrine: Changes in thyroid weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		FAATDF 33,16,1996
oral
rat 		lowest published toxic dose: 11,550 mg/kg/110 week- continuous Olfaction: Tumors HBPTO* 1,814,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,82,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
Used to control annual grasses and certain broadleaf weeds in soybeans, corn and peanuts
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
JASIAB Journal of Agricultural Science. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.1- 1905-
KHZDAN Khigiena i Zdraveopazvane. Hygiene and Sanitation. (Hemus, Blvd. Russki 6, Sofia, Bulgaria) V.9- 1966-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NNGADV Nippon Noyaku Gakkaishi. Journal of the Pesticide Science Society of Japan. (Nippon Noyaku Gakkai, 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) V.1- 1976-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RCTOE4 Reviews of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.98- 1987-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
YKYUA6 Yakkyoku. Pharmacy. (Nanzando, 4-1-11, Yushima, Bunkyo-ku, Tokyo, Japan) V.1- 1950-

Used to control annual grasses and certain broadleaf weeds in soybeans, corn and peanuts

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen

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