The Registry of Toxic Effects of Chemical Substances
Acetamide, 2 - fluoro - RTECS #: AC1225000
CAS #: 640-19-7
The Registry of Toxic Effects of Chemical Substances
Acetamide, 2 - fluoro - |
| UPDATE: August 2003 | MW: 77.07 | MF: C2H4FNO |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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cytogenetic analysis
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mammal (species unspecified)
lung
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300 µmol/L
|
HKXUDL 3,94,1983
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cytogenetic analysis
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intraperitoneal | rat
4 mg/kg
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VAAZA2 1,346,1968
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sperm morphology
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intraperitoneal | rat
4 mg/kg
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VAAZA2 1,346,1968
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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oral | rat
lowest published toxic dose: 90 mg/kg (30 day male)
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Reproductive: Paternal effects: Testes, epididymis, sperm duct
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EXPEAM 20,492,1964
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | mouse
lethal concentration (50 percent kill): 550 mg/m3
|
N/R
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ABCHA6 31,1294,1967
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intraperitoneal | mouse
lethal dose (50 percent kill): 85 mg/kg
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Behavioral: Altered sleep time (including change in righting reflex) | Behavioral: Tremor Gastrointestinal: Hypermotility, diarrhea
BCPCA6 12,1201,1963
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intraperitoneal | rat
lethal dose (50 percent kill): 12 mg/kg
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N/R
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JSFAAE 8,400,1957
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intravenous | monkey
lethal dose (50 percent kill): 5 mg/kg
|
N/R
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SKEZAP 9,1,1968
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intravenous | rabbit
lethal dose (50 percent kill): 250 µg/kg
|
N/R
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JCSOA9 -,912,1949
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oral | wild bird
lethal dose (50 percent kill): 5,620 µg/kg
|
N/R
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AECTCV 12,355,1983
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oral | chicken
lethal dose (50 percent kill): 4,250 µg/kg
|
N/R
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FLUOA4 10,34,1976
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oral | human
lowest published lethal dose: 2 mg/kg
|
N/R
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SKEZAP 9,1,1968
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oral | mouse
lethal dose (50 percent kill): 25 mg/kg
|
N/R
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ABCHA6 31,1294,1967
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oral | quail
lethal dose (50 percent kill): 13 mg/kg
|
N/R
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JRPFA4 48,371,1976
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oral | rat
lethal dose (50 percent kill): 5,750 µg/kg
|
N/R
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PCOC** -,538,1966
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subcutaneous | mouse
lethal dose (50 percent kill): 34 mg/kg
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Behavioral: Convulsions or effect on seizure threshold | Behavioral: Excitement Skin and Appendages: Other: Hair
NHOZAX 26,203,1972
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skin | mouse
lethal dose (50 percent kill): 34 mg/kg
|
N/R
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SKEZAP 9,1,1968
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skin | rat
lethal dose (50 percent kill): 80 mg/kg
|
N/R
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WRPCA2 9,119,1970
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unreported route | human
lowest published lethal dose: 5 mg/kg
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Behavioral: Convulsions or effect on seizure threshold | Behavioral: Coma Gastrointestinal: Nausea or vomiting
34ZIAG -,274,1969
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unreported route | mammal (species unspecified)
lethal dose (50 percent kill): 4 mg/kg
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N/R
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30ZDA9 -,119,1971
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
oral | wild bird
lowest published toxic dose: 15 mg/kg/7 day- intermittent
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Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
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JWIDAW 15,319,1979
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oral | cat
lowest published toxic dose: 700 µg/kg/7 day- intermittent
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Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
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JWIDAW 15,319,1979
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
TOXICOLOGY REVIEW
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CHREAY 48,225,1951
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988
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PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
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FEREAC 54,7740,1989
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Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF
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PESTICIDES: Cancelled
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RBREV* -,255,1998
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
|
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REFERENCE
N/R
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N/R
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N/R
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used as a rodenticide and as an insecticide on fruit
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On EPA IRIS database
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REFERENCES:
CODEN
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REFERENCE
30ZDA9
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"Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
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34ZIAG
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"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
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ABCHA6
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Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International,
Tokyo 100-31, Japan) V.25- 1961-
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AECTCV
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Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
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BCPCA6
|
Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY
10523) V.1- 1958-
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CHREAY
|
Chemical Reviews. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End
Stn., Washington, DC 20037) V.1- 1924-
|
EXPEAM
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Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
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FEREAC
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Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
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FLUOA4
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Fluoride. (International Soc. for Fluoride Research, Inc., POB 692, Warren, MI 48090) V.3-
1970-
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HKXUDL
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Huanjing Kexue Xuebao. Environmental Sciences Journal. (China International Book Trading
Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1981-
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JCSOA9
|
Journal of the Chemical Society. (London, UK) 1926-65. For publisher information, see
JCPRB4.
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JRPFA4
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Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way,
Colchester, Essex CO2 8HP, UK) V.1- 1960-
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JSFAAE
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Journal of the Science of Food and Agriculture. (Blackwell Scientific Pub. Inc., 52 Beacon
St., Boston, MA 02108) V.1- 1950-
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JWIDAW
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Journal of Wildlife Diseases. (Wildlife Disease Assoc., POB 886, Ames, IA 50010) V.6-
1970-
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NHOZAX
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Nippon Hoigaku Zasshi. Japanese Journal of Legal Medicine. (Nippon Hoi Gakkai, c/o Tokyo
Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1944-
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PCOC**
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Pesticide Chemicals Official Compendium, Association of the American Pesticide Control
Officials, Inc., 1966. (Topeka, KS)
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RBREV*
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Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report),
Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental
Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
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SKEZAP
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Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin Eisei Gakkai c/o Shokuhin
Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo 150, Japan) V.1- 1960-
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VAAZA2
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Virchows Archiv, Abteilung B: Cell Pathology. (Springer-Verlag, Heidelberger Pl. 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1968-
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WRPCA2
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World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.
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