The Registry of Toxic Effects of Chemical Substances

Acetamide, N,N - dimethyl - 2,2 - diphenyl -

RTECS #: AB8050000

CAS #: 957-51-7

UPDATE: August 2003 MW: 239.34 MF: C16H17NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. L - 34314
  2. Lilly 34,314
  3. Benzeneacetamide, N,N - dimethyl - alpha - phenyl - (9CI)
  4. Dif 4
  5. Difenamid (Czech)
  6. Dimethylamid kyseliny difenyloctove (Czech)
  7. N,N - Dimethyldiphenylacetamide
  8. N,N - Dimethyl - alpha,alpha - diphenylacetamide
  9. N,N,Dimethyl - 2,2 - diphenylacetamide
  10. N,N - Dimethyl - alpha - phenylbenzeneacetamide
  11. Diphenamid
  1. Diphenamide
  2. Diphenylamide
  3. 2,2 - Diphenyl - N,N - dimethylacetamide
  4. Dymid
  5. Enide
  6. Enide 50
  7. Fenam
  8. Rideon
  9. U 4513
  10. 80W
  11. Zarur


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis unreported route
mouse 		10 mg/kg TGANAK 16(1),45,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 500 mg/kg N/R GUCHAZ 6,233,1973
oral
dog 		lethal dose (50 percent kill): 1 gm/kg N/R 28ZEAL 5,84,1976
oral
monkey 		lethal dose (50 percent kill): 1 gm/kg N/R 28ZEAL 5,84,1976
oral
mouse 		lethal dose (50 percent kill): 600 mg/kg N/R PCOC** -,431,1966
oral
rat 		lethal dose (50 percent kill): 685 mg/kg N/R JDGRAX 12(1-2),155,1980
oral
rabbit 		lethal dose (50 percent kill): 1,500 mg/kg N/R 28ZEAL 5,84,1976
subcutaneous
mouse 		lethal dose (50 percent kill): 800 mg/kg N/R GUCHAZ 6,233,1973
skin
rat 		lethal dose (50 percent kill): >6,320 mg/kg N/R WRPCA2 9,119,1970
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 700 mg/kg N/R 30ZDA9 -,155,1971
unreported route
mouse 		lethal dose (50 percent kill): 700 mg/kg N/R TGANAK 16(1),45,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 7,280 mg/kg/26 week- intermittent Blood: Pigmented or nucleated red blood cells

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) 		GISAAA 40(12),75,1975


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,114,1998
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84343;
Number of Industries 2;
Total Number of Facilities 95;
Number of Occupations 3;
Total Number of Employees Exposed 374
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84343;
Number of Industries 1;
Total Number of Facilities 14;
Number of Occupations 1;
Total Number of Employees Exposed 41;
Total Number of Female Employees Exposed 14


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TGANAK Tsitologiya i Genetika. Cytology and Genetics. For English translation, see CYGEDX. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used as a selective preemergence herbicide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

ALT CAS #: 73413-06-6
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