The Registry of Toxic Effects of Chemical Substances
Acetamide, 2 - chloro - RTECS #: AB5075000
CAS #: 79-07-2
The Registry of Toxic Effects of Chemical Substances
Acetamide, 2 - chloro - |
| UPDATE: September 1998 | MW: 93.52 | MF: C2H4ClNO |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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mutation in microorganisms
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Escherichia coli
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2 mmol/L (-enzymatic activation step)
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MUREAV 210,255,1989
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intraperitoneal | mouse
lethal dose (50 percent kill): 100 mg/kg
|
N/R
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NTIS** AD277-689
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intravenous | mouse
lethal dose (50 percent kill): 180 mg/kg
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N/R
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CSLNX* NX#03764
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oral | dog
lethal dose (50 percent kill): 31 mg/kg
|
N/R
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CHHTAT 58,462,1978
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oral | mouse
lethal dose (50 percent kill): 155 mg/kg
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N/R
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CHHTAT 58,462,1978
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oral | rat
lethal dose (50 percent kill): 138 mg/kg
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Behavioral: Ataxia | Lung, Thorax, or Respiration: Dyspnea
NTIS** OTS0536947
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oral | rabbit
lethal dose (50 percent kill): 122 mg/kg
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N/R
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CHHTAT 58,462,1978
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unreported route | rat
lethal dose (50 percent kill): 70 mg/kg
|
N/R
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ARZNAD 19,1073,1969
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
oral | rat
lowest published toxic dose: 1,138 mg/kg/13 week- intermittent
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Endocrine: Thyroid weight (goiter) | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Related to Chronic Data: Changes in testicular weight
NTIS** OTS0536952
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oral | rabbit
lowest published toxic dose: 960 mg/kg/30 day- intermittent
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Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change | Cardiac: EKG changes not diagnostic of above Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
CHHTAT 58,462,1978
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skin | rabbit
lowest published toxic dose: 6 gm/kg/30 day- intermittent
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Blood: Changes in spleen | Skin: After systemic exposure: Dermatitis, other Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NTIS** OTS0536947
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REVIEWS:
ORGANIZATION
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STANDARD
|
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REFERENCE
N/R
|
N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
|
N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: T1156 |
 ;Number of Industries 1; Total Number of Facilities 3; Number of Occupations 1; Total Number of Employees Exposed 90 | |||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE
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EPA TSCA Section 8(b) CHEMICAL INVENTORY
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
ARZNAD
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Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960
Aulendorf, Fed. Rep. Ger.) V.1- 1951-
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CHHTAT
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Zhonghua Yixue Zazhi. Chinese Medical Journal. (China International Book Trading Corp., POB
2820, Beijing, Peop. Rep. China) V.1- 1915- Suspended 1967-72.
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CSLNX*
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U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange
Chemicals. (Aberdeen Proving Ground, MD 21010)
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MUREAV
|
Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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