The Registry of Toxic Effects of Chemical Substances

Acetamide

RTECS #: AB4025000

CAS #: 60-35-5

UPDATE: November 2004 MW: 59.08 MF: C2H5NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. NCI - C02108
  2. Acetic acid amide
  3. Acetimidic acid
  1. Amid kyseliny octove (Czech)
  2. Ethanamide
  3. Methanecarboxamide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
micronucleus test oral
mouse 		3,390 µmol/kg MUREAV 192,141,1987
micronucleus test oral
mouse 		100 mg/kg/30 hour- intermittent CRTXB2 31,139,2001
morphological transform hamster embryo 1 mg/L IJCNAW 19,642,1977
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 35,300,2000
morphological transform rat embryo 5 mg/L JNCIAM 51,799,1973
other mutation test systems mouse
Ascites tumor 		10 pph IDZAAW 51,53,1976


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rabbit 		lowest published toxic dose: 39 gm/kg (6-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		ARZNAD 30,1557,1980
oral
rabbit 		lowest published toxic dose: 13 gm/kg (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ARZNAD 30,1557,1980


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 517 gm/kg/1 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Tumors

Blood: Lymphoma including Hodgkin's disease 		JEPTDQ 3(5-6),149,1980
oral
rat 		lowest published toxic dose: 431 gm/kg/1 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JEPTDQ 3(5-6),149,1980
oral
rat 		toxic dose : 546 gm/kg/52 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors 		TXAPA9 14,163,1969


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 1 gm/kg N/R JJIND8 62,911,1979
intraperitoneal
rat 		lethal dose (50 percent kill): 10,300 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea 		ARZNAD 20,1242,1970
intravenous
chicken 		lowest published lethal dose: 33,410 mg/kg N/R ARZNAD 20,1242,1970
intravenous
mouse 		lethal dose (50 percent kill): 10 gm/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Eye: Lacrimation 		NYKZAU 64(1),42S,1968
intravenous
rat 		lethal dose (50 percent kill): 12,500 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Eye: Lacrimation 		NYKZAU 64(1),42S,1968
intravenous
rabbit 		lethal dose (50 percent kill): 7,500 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Eye: Lacrimation 		NYKZAU 64(1),42S,1968
oral
mouse 		lethal dose (50 percent kill): 12,900 mg/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Eye: Lacrimation 		NYKZAU 64(1),42S,1968
oral
rat 		lethal dose (50 percent kill): 7 gm/kg N/R JRPFA4 4,219,1962
subcutaneous
mouse 		lethal dose (50 percent kill): 8,300 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Autonomic Nervous System: Smooth muscle relaxant (mechanism undefined, spasmolytic)

Cardiac: Change in rate 		OYYAA2 4,451,1970
subcutaneous
rat 		lethal dose (50 percent kill): 10 gm/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Autonomic Nervous System: Smooth muscle relaxant (mechanism undefined, spasmolytic)

Cardiac: Change in rate 		OYYAA2 4,451,1970
unreported route
rat 		lethal dose (50 percent kill): 2,300 mg/kg N/R ARZNAD 18,645,1968


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMSUDL 7,389,1987
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,1211,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 7,197,1974
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1211,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,1211,1999
TOXICOLOGY REVIEW
CRTXB2 31,139,2001


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRIA Suspected Carcinogen, JAN1999
Occupational Exposure Limit - FINLAND Carcinogen, JAN1993
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - SWEDEN time-weighted average 10 ppm (23 mg/m3), short term exposure limit 25 ppm (60 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 25 mg/m3, 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81686;
Number of Industries 17;
Total Number of Facilities 404;
Number of Occupations 21;
Total Number of Employees Exposed 4,668
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81686;
Number of Industries 4;
Total Number of Facilities 132;
Number of Occupations 4;
Total Number of Employees Exposed 2,074;
Total Number of Female Employees Exposed 1,148


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-mouse embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; E coli polA with S9
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in cryoscopy as a soldering flux ingredient, as a solvent, wetting agent
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
IDZAAW Japanese Journal of Genetics. Idengaku Zasshi. (Genetics Soc. of Japan, 111 Tanida, Mishima, Shizuoka-ken, Japan) V.1- 1921-
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in cryoscopy as a soldering flux ingredient, as a solvent, wetting agent

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector

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