The Registry of Toxic Effects of Chemical Substances

Acetaldehyde, diethyl acetal

RTECS #: AB2800000

CAS #: 105-57-7

UPDATE: February 2004 MW: 118.20 MF: C6H14O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Acetaal (Dutch)
  2. Acetal
  3. Acetal diethylique (French)
  4. Acetale (Italian)
  5. 1,1 - Diaethoxy - aethan (German)
  6. Diaethylacetal (German)
  7. 1,1 - Diethoxy - ethaan (Dutch)
  1. 1,1 - Diethoxyethane
  2. Diethyl acetal
  3. 1,1 - Dietossietano (Italian)
  4. Ethane, 1,1 - diethoxy -
  5. Ethylidene diethyl ether
  6. USAF DO - 45


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 mg N/R VCVGK* -,504,1994
skin
rabbit 		500 mg/24 hour mild 85JCAE -,260,1986
skin
rabbit 		10 mg/24 hour mild VCVGK* -,504,1994


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published lethal concentration: 4,000 ppm/4 hour N/R JIHTAB 31,343,1949
inhalation
rat 		lethal concentration (50 percent kill): 19,400 mg/m3 N/R VCVGK* -,501,1994
intraperitoneal
mouse 		lethal dose (50 percent kill): 500 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat 		lethal dose (50 percent kill): 900 mg/kg N/R 14CYAT 2,1982,1963
oral
mouse 		lethal dose (50 percent kill): 3,500 mg/kg N/R VCVGK* -,501,1994
oral
rat 		lethal dose (50 percent kill): 4,600 mg/kg N/R VCVGK* -,501,1994
oral
rabbit 		lethal dose (50 percent kill): 3,545 mg/kg N/R PSEBAA 29,730,1932


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 01030;
Number of Industries 5;
Total Number of Facilities 1,217;
Number of Occupations 15;
Total Number of Employees Exposed 12,775
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 01030;
Number of Industries 1;
Total Number of Facilities 17;
Number of Occupations 1;
Total Number of Employees Exposed 165;
Total Number of Female Employees Exposed 83


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a perfume and flavoring material and as a solvent

NIOSH PROFILE (ACETAL), SRC, 3/81

RTECS Compound Description:
   Primary Irritant

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