International Chemical Safety Cards 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN ICSC: 1467 Dibenzo b,e 1,4dioxin, 2,3,7,8-tetrachloro- 2,3,7,8-TCDD 2,3,7,8-Tetrachloro-1,4-dioxin C12H4Cl4O2 Molecular mass: 322 ICSC #    1467 CAS #     1746-01-6 RTECS # HP3500000 UN #        2811 November 26, 2003 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Gives off irritating or toxic fumes (or gases) in a fire. In case of fire in the surroundings: powder, water spray, foam, carbon dioxide. EXPLOSION EXPOSURE AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!  •INHALATION Chloracne. Symptoms may be delayed. Use appropriate engineering controls. Fresh air, rest. Refer for medical attention.  •SKIN MAY BE ABSORBED! (See Inhalation). Redness. Pain. Protective gloves. Protective clothing. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.  •EYES Redness. Pain. Face shield, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION (See Inhalation). Do not eat, drink, or smoke during work. Wash hands before eating. Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Evacuate danger area! Consult an expert! Chemical protection suit including self-contained breathing apparatus. Separated from food and feedstuffs. R: S: UN Hazard Class: 6.1 UN Packing Group: I SEE IMPORTANT INFORMATION ON BACK ICSC: 1467 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN ICSC: 1467 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS TO WHITE NEEDLE-LIKE CRYSTALS PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating to 750-800°C and under the influence of UV light producing chlorine . OCCUPATIONAL EXPOSURE LIMITS: TLV not established. MAK: 10-8 mg/m³; H; Peak limitation category: II(8); Carcinogen category: 4; Pregnancy risk group: C; (DFG 2003). ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of dust, through the skin and by ingestion . INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed. EFFECTS OF SHORT-TERM EXPOSURE: The substance is irritating to the eyes , the skin and the respiratory tract . The substance may cause effects on the cardiovascular system , gastrointestinal tract , liver , nervous system and endocrine system . The effects may be delayed. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the bone marrow , endocrine system , immune system , liver and nervous system . This substance is carcinogenic to humans. Animal tests show that this substance possibly causes toxicity to human reproduction or development. PHYSICAL PROPERTIES Melting point: 305-306°C Density: 1.8 g/cm3 Solubility in water: none Vapour pressure, Pa at 25°C: negligible Octanol/water partition coefficient as log Pow: 6.8-7.02 ENVIRONMENTAL DATA The substance is very toxic to aquatic organisms. This substance may be hazardous in the environment; special attention should be given to soil contamination. Bioaccumulation of this chemical may occur in fish,in plants,in mammals and in milk. It is strongly advised that this substance does not enter the environment. N O T E S This chemical is only produced for research purposes, but could be generated as a by-product from chemical processes or fires. Transport Emergency Card: TEC (R)-61GT2-I ADDITIONAL INFORMATION ICSC: 1467 2,3,7,8-TETRACHLORODIBENZO-p-DIOXIN (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.