International Chemical Safety Cards PARACETAMOL ICSC: 1330 Acetaminophen 4-Hydroxyacetanilide p-Acetylaminophenol C8H9NO2 / HOC6H4NHCOCH3 Molecular mass: 151.2 ICSC #    1330 CAS #     103-90-2 RTECS # AE4200000 November 25, 1998 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. NO open flames. Powder, alcohol-resistant foam, water spray, carbon dioxide. EXPLOSION EXPOSURE PREVENT DISPERSION OF DUST!  •INHALATION See Notes. Local exhaust or breathing protection. Fresh air, rest.  •SKIN Protective gloves. Rinse skin with plenty of water or shower.  •EYES Safety spectacles, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Nausea. Vomiting. Diarrhoea. Drowsiness. Abdominal pain. Unconsciousness. Do not eat, drink, or smoke during work. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give plenty of water to drink. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Sweep spilled substance into containers. Do NOT let this chemical enter the environment. (Extra personal protection: P2 filter respirator for harmful particles). R: S: SEE IMPORTANT INFORMATION ON BACK ICSC: 1330 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards PARACETAMOL ICSC: 1330 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS CRYSTALS OR CRYSTALLINE POWDER PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating above 45°C. OCCUPATIONAL EXPOSURE LIMITS: TLV not established. MAK not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especialy if powdered. EFFECTS OF SHORT-TERM EXPOSURE: The substance may cause effects on the liver and kidney , resulting in liver impairment and kidney impairment only in case of large amount ingested. The effects may be delayed. Medical observation is indicated. See Notes. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: The substance may have effects on the kidneys and liver , resulting in impaired functions. May cause genetic damage in humans. PHYSICAL PROPERTIES Boiling point: >500°C Melting point: 169-170°C Solubility in water, g/100 ml at 20°C: 1.4 Octanol/water partition coefficient as log Pow: 0.49 ENVIRONMENTAL DATA The substance is toxic to aquatic organisms. N O T E S Temperature of decomposition unknown in literature. Health effects of exposure by inhalation to the substance have not been investigated. Use of alcoholic beverages enhances the harmful effect. The symptoms of acute intoxications do not become manifest until some 24-48 h to 3-4 days after ingestion of toxic doses. APAP, Panadol, Tempra, Tylenol are trade names. ADDITIONAL INFORMATION ICSC: 1330 PARACETAMOL (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.