International Chemical Safety Cards 4-BROMOANILINE ICSC: 1226 4-Bromobenzeneamine p-Bromophenylamine p-Bromoaniline C6H6BrN / BrC6H4NH2 Molecular mass: 172.0 ICSC #    1226 CAS #     106-40-1 RTECS # BW9280000 April 20, 2004 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Powder, water spray, foam, carbon dioxide. EXPLOSION EXPOSURE STRICT HYGIENE!  •INHALATION Blue lips or finger nails. Blue skin. Headache. Nausea. Local exhaust or breathing protection. Fresh air, rest. Refer for medical attention.  •SKIN Protective gloves. Rinse and then wash skin with water and soap.  •EYES Safety spectacles, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Blue lips or fingernails. Blue skin. Dizziness. Headache. Laboured breathing. Nausea. Confusion. Convulsions. Unconsciousness. Do not eat, drink, or smoke during work. Rinse mouth. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Personal protection: P2 filter respirator for harmful particles. Do NOT let this chemical enter the environment. Separated from strong oxidants, acids. Well closed. R: S: SEE IMPORTANT INFORMATION ON BACK ICSC: 1226 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards 4-BROMOANILINE ICSC: 1226 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS CRYSTALS PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating or on burning producing toxic and corrosive fumes including hydrogen bromide and nitrogen oxides (see ICSC 0282). The solution in water is a weak base. Reacts with acids strong oxidants . OCCUPATIONAL EXPOSURE LIMITS: TLV not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. INHALATION RISK: No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance may cause effects on the blood , resulting in formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: The substance may have effects on the blood , resulting in the formation of methaemoglobin. PHYSICAL PROPERTIES Boiling point: 223°C Melting point: 66°C Relative density (water = 1): 1.5 at 100°C Solubility in water: poor Vapour pressure, Pa at 25°C: 22.6 Relative vapour density (air = 1): 5.9 Octanol/water partition coefficient as log Pow: 2.26 ENVIRONMENTAL DATA The substance is harmful to aquatic organisms. N O T E S Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. ADDITIONAL INFORMATION ICSC: 1226 4-BROMOANILINE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.