International Chemical Safety Cards CRUFOMATE ICSC: 1143 4-tert-Butyl-2-chlorophenyl methyl methylphosphoramidate Amidophos C12H19ClNO3P Molecular mass: 291.7 ICSC #    1143 CAS #     299-86-5 RTECS # TB3850000 UN #        2783 EC #         015-074-00-X October 25, 1995 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Liquid formulations containing organic solvents may be flammable. NO open flames. Water spray, powder. EXPLOSION EXPOSURE AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN!  •INHALATION Dizziness. Sweating. Laboured breathing. Nausea. Unconsciousness. Vomiting. Pupillary constriction, muscle cramp, excessive salivation. Avoid inhalation of fine dust and mist. Local exhaust or breathing protection. Fresh air, rest. Refer for medical attention.  •SKIN MAY BE ABSORBED! Redness. (Further see Inhalation). Protective gloves. Protective clothing. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.  •EYES Redness. Pain. Face shield or eye protection in combination with breathing protection if powder. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Abdominal cramps. Diarrhoea. Nausea. Vomiting. Pupillary constriction, muscle cramps, excessive salivation. Do not eat, drink, or smoke during work. Wash hands before eating. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Do NOT wash away into sewer. Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Personal protection: complete protective clothing including self-contained breathing apparatus. Separated from strong bases, strong acids, food and feedstuffs . Well closed. Keep in a well-ventilated room. Do not transport with food and feedstuffs. Xn symbol N symbol R: 21/22-50/53 S: 2-36/37-60-61 UN Hazard Class: 6.1 UN Packing Group: III SEE IMPORTANT INFORMATION ON BACK ICSC: 1143 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards CRUFOMATE ICSC: 1143 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: WHITE CRYSTALS. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating producing toxic and corrosive fumes including hydrogen chloride , nitrogen oxides and phosphorus oxides Reacts with strong acids strong bases . OCCUPATIONAL EXPOSURE LIMITS: TLV: 5 mg/m³ as TWA; A4 (not classifiable as a human carcinogen); BEI issued; (ACGIH 2004). OSHA PEL: none NIOSH REL: TWA 5 mg/m3 ST 20 mg/m3 NIOSH IDLH: No data ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying or when dispersed, especially if powdered. EFFECTS OF SHORT-TERM EXPOSURE: The substance is irritating to the eyes , the skin and the respiratory tract . The substance may cause effects on the nervous system , resulting in convulsions and respiratory failure . Cholinesterase inhibitor. The effects may be delayed. Medical observation is indicated. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: PHYSICAL PROPERTIES Melting point (decomposes): 60-65°C Relative density (water = 1): 1.5 Solubility in water, g/100 ml: none Vapour pressure, Pa at 25°C: 0.106 ENVIRONMENTAL DATA The substance is very toxic to aquatic organisms. This substance does enter the environment under normal use. Great care, however, should be given to avoid any additional release, e.g. through inappropriate disposal. N O T E S Depending on the degree of exposure, periodic medical examination is suggested. Carrier solvents used in commercial formulations may change physical and toxicological properties. Do NOT take working clothes home. Commercial product is a yellow oil. Ruelene is a trade name. Card has been partly updated in April 2005. See sections Occupational Exposure Limits, Emergency Response. Transport Emergency Card: TEC (R)-61GT7-III ADDITIONAL INFORMATION ICSC: 1143 CRUFOMATE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.