International Chemical Safety Cards ROTENONE ICSC: 0944 Tubotoxine Derris powder C23H22O6 Molecular mass: 394.45 ICSC #    0944 CAS #     83-79-4 RTECS # DJ2800000 UN #        2588 EC #         650-005-00-2 April 13, 2000 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. NO open flames. Powder, alcohol-resistant foam, water spray, carbon dioxide. EXPLOSION EXPOSURE PREVENT DISPERSION OF DUST! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN! IN ALL CASES CONSULT A DOCTOR!  •INHALATION Confusion. Cough. Headache. Tremor. Laboured breathing. Nausea. Sore throat. Unconsciousness. Local exhaust or breathing protection. Fresh air, rest. Artificial respiration if indicated.  •SKIN Redness. Protective gloves. First rinse with plenty of water, then remove contaminated clothes and rinse again. Rinse and then wash skin with water and soap.  •EYES Redness. Safety goggles, or eye protection in combination with breathing protection if powder. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Abdominal cramps. Convulsions. Diarrhoea. Vomiting. (Further see Inhalation). Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Give a slurry of activated charcoal in water to drink. Rest. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Sweep spilled substance into air tight containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. (Extra personal protection: P3 filter respirator for toxic particles). Do NOT let this chemical enter the environment. Separated from food and feedstuffs . Well closed. Do not transport with food and feedstuffs. Marine pollutant. T symbol N symbol R: 25-36/37/38-50/53 S: 1/2-22-24/25-36-45-60-61 UN Hazard Class: 6.1 UN Packing Group: III SEE IMPORTANT INFORMATION ON BACK ICSC: 0944 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards ROTENONE ICSC: 0944 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS CRYSTALS PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on burning producing irritating fumes . OCCUPATIONAL EXPOSURE LIMITS: TLV: 5 mg/m3 (as TWA) (ACGIH 1999). MAK: 5 mg/m3; (respirable fraction) (1999) OSHA PEL: TWA 5 mg/m3 NIOSH REL: TWA 5 mg/m3 NIOSH IDLH: 2500 mg/m3 ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation and by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly. EFFECTS OF SHORT-TERM EXPOSURE: The substance irritates the eyes, the skin and the respiratory tract. The substance may cause effects on the central nervous system , resulting in convulsions and respiratory depression. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the kidneys and liver . PHYSICAL PROPERTIES Decomposes below boiling point Melting point: 165-166°C Density: 1.27 g/cm3 Solubility in water: none Octanol/water partition coefficient as log Pow: 4.10 ENVIRONMENTAL DATA The substance is very toxic to aquatic organisms. Avoid release to the environment in circumstances different to normal use. The substance may cause long-term effects in the aquatic environment. N O T E S The substance is combustible but no flash point is available in literature. Carrier solvents used in commercial formulations may change physical and toxicological properties. Depending on the degree of exposure, periodic medical examination is indicated. Transport Emergency Card: TEC (R)-61G41c ADDITIONAL INFORMATION ICSC: 0944 ROTENONE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.