International Chemical Safety Cards IOXYNIL ICSC: 0900 3,5-Diiodo-4-hydroxybenzonitrile 4-Hydroxy-3,5-diiodobenzonitrile 4-Cyano-2,6-diiodophenol C7H3I2NO Molecular mass: 370.9 ICSC #    0900 CAS #     1689-83-4 RTECS # DI4025000 UN #        2588 EC #         608-007-00-6 October 08, 1997 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Powder, water spray, foam, carbon dioxide. EXPLOSION Finely dispersed particles form explosive mixtures in air. Prevent deposition of dust; closed system, dust explosion-proof electrical equipment and lighting. EXPOSURE STRICT HYGIENE! AVOID EXPOSURE OF (PREGNANT) WOMEN! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN! IN ALL CASES CONSULT A DOCTOR!  •INHALATION Dizziness. Headache. Sweating. Vomiting. Weakness. Fever. Local exhaust or breathing protection. Fresh air, rest. Refer for medical attention.  •SKIN MAY BE ABSORBED! Pain. Redness. Protective gloves. Protective clothing. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.  •EYES Pain. Redness. Safety goggles, or face shield. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION (See Inhalation). Do not eat, drink, or smoke during work. Wash hands before eating. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Personal protection: P3 filter respirator for toxic particles. Do NOT let this chemical enter the environment. Provision to contain effluent from fire extinguishing. Separated from strong oxidants, food and feedstuffs . Do not transport with food and feedstuffs. Marine pollutant. T symbol N symbol R: 21-23/25-36-48/22-63-50/53 S: 1/2-36/37-45-60-61-63 UN Hazard Class: 6.1 UN Packing Group: III SEE IMPORTANT INFORMATION ON BACK ICSC: 0900 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards IOXYNIL ICSC: 0900 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: ODOURLESS COLOURLESS CRYSTALS PHYSICAL DANGERS: Dust explosion possible if in powder or granular form, mixed with air. CHEMICAL DANGERS: The substance decomposes on burning producing toxic fumes,includingnitrogen oxides, iodine and cyanide compounds. OCCUPATIONAL EXPOSURE LIMITS: TLV not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. INHALATION RISK: No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance is mildly irritating to the eyes and the skin . EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Animal tests show that this substance possibly causes malformations in human babies. PHYSICAL PROPERTIES Melting point: 212-213°C Solubility in water: none Vapour pressure, Pa at 20°C: <0.001 Octanol/water partition coefficient as log Pow: 3.51 ENVIRONMENTAL DATA The substance is toxic to aquatic organisms. Avoid release to the environment in circumstances different to normal use. N O T E S Carrier solvents used in commercial formulations may change physical and toxicological properties. Actril, Bentrol, Certol, Iotril, Toxynil are trade names. Card has been partly updated in October 2004. See sections Occupational Exposure Limits, EU classification, Emergency Response. Transport Emergency Card: TEC (R)-61GT7-III NFPA Code: H2; F1; R0; ADDITIONAL INFORMATION ICSC: 0900 IOXYNIL (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.