International Chemical Safety Cards

ENFLURANE

ICSC: 0887

2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether
2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
Ethrane
Ether, 2-chloro-1,1,2-trifluoroethyl difluoromethyl
C₃H₂ClF₅O / CHF₂OCF₂CHClF
Molecular mass: 184.50
ICSC # 0887
CAS # 13838-16-9
RTECS # KN6800000
October 10, 2002 Peer reviewed

TYPES OF HAZARD/ EXPOSURE	ACUTE HAZARDS/ SYMPTOMS	PREVENTION	FIRST AID/ FIRE FIGHTING
FIRE	Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.		In case of fire in the surroundings: use appropriate extinguishing media.
EXPLOSION

EXPOSURE
•INHALATION	Cough. Sore throat. Drowsiness. Weakness. Unconsciousness. See Notes.	Ventilation, local exhaust, or breathing protection.	Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.
•SKIN	Redness. Dry skin.	Protective gloves.	Remove contaminated clothes. Rinse skin with plenty of water or shower.
•EYES	Redness. Pain.	Safety spectacles, or eye protection in combination with breathing protection.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION	(See Inhalation).	Do not eat, drink, or smoke during work.	Rinse mouth. Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. (Extra personal protection: self-contained breathing apparatus).

Keep in a well-ventilated room.

R:
S:

SEE IMPORTANT INFORMATION ON BACK

ICSC: 0887

Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

ENFLURANE

ICSC: 0887

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PHYSICAL STATE; APPEARANCE:
COLOURLESS LIQUID , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:
The vapour is heavier than air and may accumulate in lowered spaces causing a deficiency of oxygen.

CHEMICAL DANGERS:
The substance decomposes on heating producing toxic and corrosive fumes ( hydrogen chloride , hydrogen fluoride ). Attacks some plastic and rubber .

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 75 ppm as TWA; A4; (ACGIH 2002).
MAK: 20 ppm;
Peak limitation category: II(8); Pregnancy risk group: C;
(DFG 2002).
OSHA PEL: none
NIOSH REL: C 2 ppm (15.1 mg/m³) 60-minute *Note: REL for exposure to waste anesthetic gas.
NIOSH IDLH: No data

ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

INHALATION RISK:
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance is irritating to the eyes , the skin and the respiratory tract . The substance may cause effects on the central nervous system and cardiovascular system . Exposure at high levels may result in unconsciousness.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:

PHYSICAL
PROPERTIES

Boiling point: 56.5°C
Relative density (water = 1): 1.52
Solubility in water: poor
Vapour pressure, kPa at 20°C: 23.3

Relative vapour density (air = 1): 1.9
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.12
Explosive limits, vol% in air: 4.25-?

ENVIRONMENTAL
DATA

N O T E S

Other names: Anesthetic compound no. 347, NCS-115944, Alyrane, Efrane, Ohio 347. Other CAS numbers: (+)-enflurane CAS 22194-21-4; (-)-enflurane CAS 22194-22-5. Check oxygen content before entering area. High concentrations in the air cause a deficiency of oxygen with the risk of unconsciousness or death.

ADDITIONAL INFORMATION

ICSC: 0887	ENFLURANE
(C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE:

Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.