International Chemical Safety Cards DEMETON-METHYL ICSC: 0862 S-2-Ethylthioethyl O,O-dimethyl phosphorothioate C6H15O3PS2 Molecular mass: 230.3 ICSC #    0862 CAS #     8022-00-2 RTECS # TG1760000 UN #        3018 EC #         015-031-00-5 March 11, 2001 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Liquid formulations containing organic solvents may be flammable. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Powder, water spray, foam, carbon dioxide. EXPLOSION EXPOSURE PREVENT GENERATION OF MISTS! STRICT HYGIENE! AVOID EXPOSURE OF ADOLESCENTS AND CHILDREN! IN ALL CASES CONSULT A DOCTOR!  •INHALATION Convulsions. Dizziness. Laboured breathing. Nausea. Pupillary constriction, muscle cramp, excessive salivation. Sweating. Unconsciousness. Ventilation, local exhaust, or breathing protection. Fresh air, rest. Refer for medical attention.  •SKIN MAY BE ABSORBED! (See Inhalation). Protective clothing. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.  •EYES Pupillary constriction. Blurred vision. Face shield, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION (See Inhalation). Abdominal cramps. Diarrhoea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. (Extra personal protection: P2 filter respirator for harmful particles.) Do NOT let this chemical enter the environment. Keep in a well-ventilated room. Separated from food and feedstuffs . Do not transport with food and feedstuffs. T symbol N symbol R: 24/25-51/53 S: 1/2-28-36/37-45-61 UN Hazard Class: 6.1 UN Packing Group: III SEE IMPORTANT INFORMATION ON BACK ICSC: 0862 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards DEMETON-METHYL ICSC: 0862 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS TO PALE YELLOW OILY LIQUID , WITH CHARACTERISTIC ODOUR. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on burning producing phosphorous oxides and sulfur oxides. OCCUPATIONAL EXPOSURE LIMITS: OSHA PEL: none NIOSH REL: TWA 0.5 mg/m3 skin NIOSH IDLH: No data ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation, through the skin and by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly on spraying. EFFECTS OF SHORT-TERM EXPOSURE: The substance may cause effects on the central nervous system . Cholinesterase inhibitor. Medical observation is indicated. The effects may be delayed. Exposure may result in death. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: PHYSICAL PROPERTIES Relative density (water = 1): 1.2 Solubility in water, g/100 ml at 20°C: 2.2 Vapour pressure, Pa at 20°C: 0.04 Octanol/water partition coefficient as log Pow: 1.32 ENVIRONMENTAL DATA The substance is toxic to aquatic organisms. This substance may be hazardous to the environment; special attention should be given to honey bees, mammals and birds. Avoid release to the environment in circumstances different to normal use. N O T E S Demeton-methyl is a mixture of Demeton-S-methyl and Demeton-O-methyl. If the substance is formulated with solvent(s) also consult the card(s) (ICSC) of the solvent(s). Carrier solvents used in commercial formulations may change physical and toxicological properties. Also consult ICSC 0429 Demeton-O-methyl, ICSC 0705 Demeton-S-methyl. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Depending on the degree of exposure, periodic medical examination is indicated. Metasystox is a trade name. Transport Emergency Card: TEC (R)-61G43b ADDITIONAL INFORMATION ICSC: 0862 DEMETON-METHYL (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.