International Chemical Safety Cards DINITROBENZENE (mixed isomers) ICSC: 0725 Dinitrobenzol (mixed isomers) Benzene, dinitro DNB C6H4(NO2)2 / C6H4N2O4 Molecular mass: 168.1 ICSC #    0725 CAS #     25154-54-5 RTECS # CZ7340000 UN #        1597 EC #         609-004-00-2 October 18, 2001 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Powder, water spray, foam, carbon dioxide. EXPLOSION Finely dispersed particles form explosive mixtures in air. Prevent deposition of dust; closed system, dust explosion-proof electrical equipment and lighting. In case of fire: keep drums, etc., cool by spraying with water. Combat fire from a sheltered position. EXPOSURE PREVENT DISPERSION OF DUST! STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR!  •INHALATION Burning sensation. Headache. Blue lips or finger nails. Blue skin. Weakness. Dizziness. Laboured breathing. Nausea. Drowsiness. Local exhaust or breathing protection. Fresh air, rest. Artificial respiration may be needed. Refer for medical attention.  •SKIN MAY BE ABSORBED! (Further see Inhalation). Protective gloves. Protective clothing. Remove contaminated clothes. Rinse and then wash skin with water and soap. Refer for medical attention.  •EYES Redness. Pain. Face shield or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION (See Inhalation). Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give a slurry of activated charcoal in water to drink. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. Personal protection: complete protective clothing including self-contained breathing apparatus. Do NOT let this chemical enter the environment. Separated from strong oxidants, powdered metals , food and feedstuffs . Well closed. Do not transport with food and feedstuffs. Note: C T+ symbol N symbol R: 26/27/28-33-50/53 S: 1/2-28-36/37-45-60-61 UN Hazard Class: 6.1 UN Packing Group: II SEE IMPORTANT INFORMATION ON BACK ICSC: 0725 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards DINITROBENZENE (mixed isomers) ICSC: 0725 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: WHITE TO PALE YELLOW CRYSTALS , WITH CHARACTERISTIC ODOUR. PHYSICAL DANGERS: Dust explosion possible if in powder or granular form, mixed with air. CHEMICAL DANGERS: May explode on heating even in the absence of air. Reacts violently with powdered metals and strong oxidants causing fire and explosion hazard. The substance decomposes on heating producing toxic fumes including nitrogen oxides . OCCUPATIONAL EXPOSURE LIMITS: TLV: 0.15 ppm as TWA; (skin); (ACGIH 2004). MAK: skin absorption (H); Carcinogen category: 3B; (DFG 2004). ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation and through the skin and by ingestion. INHALATION RISK: A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance is irritating to the eyes and the respiratory tract . The substance may cause effects on the blood , resulting in the formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: The substance may have effects on the blood and liver , resulting in anaemia and liver impairment. The substance may have effects on the nervous system , and may cause impairment in visual acuity. Animal tests show that this substance possibly causes toxicity to human reproduction or development. PHYSICAL PROPERTIES Boiling point: about 300°C Density: 1.6 g/cm3 Solubility in water: poor Vapour pressure, kPa at 20°C: <0.1 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.01 Flash point: 150°C c.c. Auto-ignition temperature: 470°C Octanol/water partition coefficient as log Pow: 1.46-1.58 ENVIRONMENTAL DATA The substance is toxic to aquatic organisms. N O T E S Use of alcoholic beverages enhances the harmful effect. Depending on the degree of exposure, periodic medical examination is suggested. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. See ICSC 0460: o-dinitrobenzene, 0691: m-dinitrobenzene, 0692: p-dinitrobenzene. Card has been partly updated in April 2005. See sections Occupational Exposure Limits, EU classification, Emergency Response. Transport Emergency Card: TEC (R)-61S1597-S NFPA Code: H 3; F 1; R 4; for o-DNB. ADDITIONAL INFORMATION ICSC: 0725 DINITROBENZENE (mixed isomers) (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.