International Chemical Safety Cards CYCLOPHOSPHAMIDE ICSC: 0689 2-Bis(2-chloroethyl)amino N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide C7H15Cl2N2O2P Molecular mass: 261.1 ICSC #    0689 CAS #     50-18-0 RTECS # RP5950000 October 08, 1997 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Powder, water spray, foam, carbon dioxide. EXPLOSION EXPOSURE PREVENT DISPERSION OF DUST! AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!  •INHALATION See Ingestion. Closed system and ventilation. Fresh air, rest. Refer for medical attention.  •SKIN Redness. Pain. Protective gloves. Protective clothing. Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.  •EYES Redness. Pain. Face shield, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Diarrhoea. Dizziness. Headache. Nausea. Vomiting. Do not eat, drink, or smoke during work. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Consult an expert! Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Carefully collect remainder, then remove to safe place. (Extra personal protection: P3 filter respirator for toxic particles). Separated from food and feedstuffs . See Chemical Dangers. Dry. Keep in the dark. Well closed. R: S: SEE IMPORTANT INFORMATION ON BACK ICSC: 0689 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards CYCLOPHOSPHAMIDE ICSC: 0689 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: FINE, WHITE, ODOURLESS CRYSTALLINE POWDER (MONOHYDRATE). LIQUEFIES ON LOSS OF ITS WATER OF CRYSTALLIZATION. TURNS DARK ON EXPOSURE TO LIGHT. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on burning producing toxic fumes including phosphorus oxides and nitrogen oxides . OCCUPATIONAL EXPOSURE LIMITS: TLV not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its aerosol, and by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered. EFFECTS OF SHORT-TERM EXPOSURE: The substance is irritating to the eyes, the skin and the respiratory tract. The substance may cause effects on the blood, bladder, central nervous system and heart. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: The substance may have effects on the blood, bladder, lungs andbone marrow , resulting in leucopenia, cystitis, pulmonary fibrosis. This substance is carcinogenic to humans. May cause heritable genetic damage in humans. Does cause serious reproductive toxicity in humans. PHYSICAL PROPERTIES Melting point: (monohydrate) 41-45°C Solubility in water, g/100 ml: 4 ENVIRONMENTAL DATA N O T E S The substance is combustible but no flash point is available in literature. Depending on the degree of exposure, periodic medical examination is suggested. Do NOT take working clothes home. Endoxan, Mitoxan, Genoxal, Procytox, Sendoxan, Cytophosphan are trade names. ADDITIONAL INFORMATION ICSC: 0689 CYCLOPHOSPHAMIDE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.