International Chemical Safety Cards TRIMETHYL PHOSPHATE ICSC: 0686 Phosphoric acid trimethyl ester Trimethyl orthophosphate C3H9O4P / (CH3O)3PO Molecular mass: 140.1 ICSC #    0686 CAS #     512-56-1 RTECS # TC8225000 October 26, 2004 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Alcohol-resistant foam, dry powder, carbon dioxide water spray . EXPLOSION EXPOSURE AVOID ALL CONTACT!  •INHALATION Cough. Sore throat. Ventilation, local exhaust, or breathing protection. Fresh air, rest. Refer for medical attention.  •SKIN Redness. Protective gloves. Protective clothing. Remove contaminated clothes. Rinse skin with plenty of water or shower.  •EYES Redness. Safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Shortness of breath. Weakness. Hyperirritability. Tremors. Do not eat, drink, or smoke during work. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Personal protection: chemical protection suit including self-contained breathing apparatus. Separated from strong oxidants, strong bases. R: S: SEE IMPORTANT INFORMATION ON BACK ICSC: 0686 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards TRIMETHYL PHOSPHATE ICSC: 0686 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS LIQUID. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on burning producing toxic fumes including phosphorous oxides . Reacts with strong bases and strong oxidants . May explode on heating during large scale atmospheric pressure distillation. OCCUPATIONAL EXPOSURE LIMITS: TLV not established. MAK: skin H; Carcinogen category: 3B; Germ cell mutagen group: 2; (DFG 2004). ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. INHALATION RISK: No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance is irritating to the eyes , the skin and the respiratory tract . The substance may cause effects on the nervous system. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: The substance may have effects on the nervous system , resulting in flaccid paralysis. May cause heritable genetic damage to human germ cells. PHYSICAL PROPERTIES Boiling point: 197.2°C Melting point: -46°C Relative density (water = 1): 1.2 Solubility in water, g/100 ml at 25°C: 50 ( good ) Vapour pressure, kPa at 20°C: 0.11 Flash point: 107°C Octanol/water partition coefficient as log Pow: -0.52 and -0.78 ENVIRONMENTAL DATA N O T E S ADDITIONAL INFORMATION ICSC: 0686 TRIMETHYL PHOSPHATE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.