International Chemical Safety Cards THEOPHYLLINE ICSC: 0678 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione 1,3-Dimethylxanthine C7H8N4O2 Molecular mass: 180.2 ICSC #    0678 CAS #     58-55-9 RTECS # XH3850000 September 23, 1993 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Not combustible. Gives off irritating or toxic fumes (or gases) in a fire. In case of fire in the surroundings: all extinguishing agents allowed. EXPLOSION EXPOSURE AVOID EXPOSURE OF (PREGNANT) WOMEN! IN ALL CASES CONSULT A DOCTOR!  •INHALATION (See Ingestion). Avoid inhalation of fine dust and mist. Fresh air, rest. Refer for medical attention.  •SKIN Protective gloves. Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention.  •EYES Safety spectacles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Convulsions. Headache. Nausea. Vomiting. Irritability. Insomnia. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Give a slurry of activated charcoal in water to drink. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Sweep spilled substance into sealable containers; if appropriate, moisten first to prevent dusting. Then remove to safe place. (Extra personal protection: P2 filter respirator for harmful particles). Separated from food and feedstuffs. Do not transport with food and feedstuffs. R: S: SEE IMPORTANT INFORMATION ON BACK ICSC: 0678 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards THEOPHYLLINE ICSC: 0678 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: COLOURLESS, WHITE CRYSTALLINE POWDER. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating producing toxic fumes including nitrogen oxides. OCCUPATIONAL EXPOSURE LIMITS: TLV not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. INHALATION RISK: No indication can be given about the rate in which a harmful concentration in the air is reached on evaporation of this substance at 20°C. EFFECTS OF SHORT-TERM EXPOSURE: The substance may cause effects on the cardiovascular system, central nervous system, liver. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: Animal tests show that this substance possibly causes toxic effects upon human reproduction. PHYSICAL PROPERTIES Melting point: 270-274°C Solubility in water, g/100 ml: moderate Octanol/water partition coefficient as log Pow: -0.02 (estimated) ENVIRONMENTAL DATA N O T E S Accurbrom, Bilordyl, Bronchorectard, Elixicon, Lasma, Sabidal, Theochram, Xanthium are trade names. ADDITIONAL INFORMATION ICSC: 0678 THEOPHYLLINE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.