International Chemical Safety Cards DIETHYL SULFATE ICSC: 0570 Sulfuric acid diethyl ester DES C4H10O4S / (C2H5)2SO4 Molecular mass: 154.2 ICSC #    0570 CAS #     64-67-5 RTECS # WS7875000 UN #        1594 EC #         016-027-00-6 March 23, 1999 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Powder, water spray, foam, carbon dioxide. EXPLOSION EXPOSURE AVOID ALL CONTACT! IN ALL CASES CONSULT A DOCTOR!  •INHALATION Cough. Laboured breathing. Shortness of breath. Sore throat. Symptoms may be delayed (see Notes). Ventilation, local exhaust, or breathing protection. Fresh air, rest. Half-upright position. Refer for medical attention.  •SKIN Redness. Serious skin burns. Pain. Protective gloves. Protective clothing. First rinse with plenty of water, then remove contaminated clothes and rinse again. Refer for medical attention.  •EYES Redness. Pain. Blurred vision. Severe deep burns. Face shield, or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Abdominal pain. Burning sensation. Nausea. Sore throat. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Do NOT induce vomiting. Give nothing to drink. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Collect leaking liquid in sealable containers. Absorb remaining liquid in sand or inert absorbent and remove to safe place. Do NOT let this chemical enter the environment. (Extra personal protection: complete protective clothing including self-contained breathing apparatus). Separated from food and feedstuffs . Dry. Well closed. Keep in a well-ventilated room. Do not transport with food and feedstuffs. Note: E T symbol R: 45-46-20/21/22-34 S: 53-45 UN Hazard Class: 6.1 UN Packing Group: II SEE IMPORTANT INFORMATION ON BACK ICSC: 0570 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards DIETHYL SULFATE ICSC: 0570 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: OILY COLOURLESS LIQUID , WITH CHARACTERISTIC ODOUR. TURNS BROWN ON EXPOSURE TO AIR. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on heating producing flammable and toxic fumes. OCCUPATIONAL EXPOSURE LIMITS: TLV not established. ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation, and by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed. EFFECTS OF SHORT-TERM EXPOSURE: The substance irritates the eyes, the skin and the respiratory tract. Inhalation of the aerosol may cause lung oedema (see Notes). The effects may be delayed. Medical observation is indicated. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: This substance is probably carcinogenic to humans. May cause heritable genetic damage in humans. PHYSICAL PROPERTIES Boiling point (decomposes): 209°C Melting point: -25°C Relative density (water = 1): 1.2 Solubility in water, g/100 ml at 25°C: 0.7 (poor) Vapour pressure, Pa at 20°C: 20 Relative vapour density (air = 1): 5.3 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.001 Flash point: 104°C c.c. Auto-ignition temperature: 436°C Explosive limits, vol% in air: 4.1-? Octanol/water partition coefficient as log Pow: 1.14 ENVIRONMENTAL DATA The substance is harmful to aquatic organisms. N O T E S The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation is therefore essential. Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered. Rinse contaminated clothes (fire hazard) with plenty of water. Transport Emergency Card: TEC (R)-61G16b NFPA Code: H3; F1; R1; ADDITIONAL INFORMATION ICSC: 0570 DIETHYL SULFATE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.